Pharmacological Targeting of the Host–Pathogen Interaction: Alternatives to Classical Antibiotics to Combat Drug-Resistant Superbugs

Autor: Munguia, Jason, Nizet, Victor

Publikováno v: In Trends in Pharmacological Sciences May 2017 38(5):473-488

HIV-1 Vpu Protein Antagonizes Innate Restriction Factor BST-2 via Lipid-embedded Helix-Helix Interactions

Autor: Skasko, Mark, Wang, Yan, Tian, Ye, Tokarev, Andrey, Munguia, Jason, Ruiz, Autumn, Stephens, Edward B., Opella, Stanley J., Guatelli, John ^**

Publikováno v: In Journal of Biological Chemistry 2 January 2012 287(1):58-67

Docking simulation and antibiotic discovery targeting the MlaC protein in Gram-negative bacteria

Autor: Huang, Yu-Ming M, Munguia, Jason, Miao, Yinglong, Nizet, Victor, McCammon, J Andrew

Publikováno v: Chemical biology & drug design, vol 93, iss 4

To maintain the lipid asymmetry of the cell envelope in Gram-negative bacteria, the MlaC protein serves as a lipid transfer factor and delivers phospholipids from the outer to the inner membrane. A strategy of antibiotic discovery is to design a prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::01cf19f010dcada629c2ceb8c1ebab18
https://escholarship.org/uc/item/5373b461

New Approaches to Sensitize Multidrug-Resistant Gram-Negative Bacterial Pathogens to Host Innate Immune Clearance

Autor: Munguia, Jason

Publikováno v: Munguia, Jason. (2016). New Approaches to Sensitize Multidrug-Resistant Gram-Negative Bacterial Pathogens to Host Innate Immune Clearance. UC San Diego: Biomedical Sciences. Retrieved from: http://www.escholarship.org/uc/item/2p92t14d

Multidrug-resistant Gram-negative (MDRGN) bacterial pathogens pose a significant threat to public health in the US and worldwide. The lack of therapeutic options for MDRGN bacterial infection have forced clinicians to use older, once rarely used anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::8ab867438ac5a6cf9d6e60ee19bd5be0
http://www.escholarship.org/uc/item/2p92t14d

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