Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Munetoyo Toda"'
Autor:
Munetoyo Toda, Morio Ueno, Jun Yamada, Asako Hiraga, Kazuko Asada, Junji Hamuro, Chie Sotozono, Shigeru Kinoshita
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract This study aims to clarify the immunogenicity in acquired and innate immune responses of cultured human corneal endothelial cells (hCECs) applied for cell injection therapy, a newly established modality for corneal endothelium failures. Thir
Externí odkaz:
https://doaj.org/article/0ac3782f0d1648d4906ef7600e52e045
Autor:
Koji Kitazawa, MD, PhD, Munetoyo Toda, PhD, Morio Ueno, MD, Asako Uehara, Chie Sotozono, MD, PhD, Shigeru Kinoshita, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 3, Iss 2, Pp 100239- (2023)
Purpose: Corneal endothelial cell density (ECD) gradually decreases after corneal transplantation by unknown biologic, biophysical, or immunologic mechanism. Our purpose was to assess the association between donor corneal endothelial cell (CEC) matur
Externí odkaz:
https://doaj.org/article/b97150f0a35149c9b8f3a1b37954109e
Cellular Interplay Through Extracellular Vesicle miR-184 Alleviates Corneal Endothelium Degeneration
Autor:
Tomoko Yamashita, PhD, Kazuko Asada, BEng, Morio Ueno, MD, PhD, Nao Hiramoto, PhD, Tomoko Fujita, BEd, Munetoyo Toda, PhD, Chie Sotozono, MD, PhD, Shigeru Kinoshita, MD, PhD, Junji Hamuro, PhD
Publikováno v:
Ophthalmology Science, Vol 2, Iss 4, Pp 100212- (2022)
Objective: The objective of the study was to reveal the presence of cellular interplay through extracellular vesicle (EV) microRNAs (miRs), to dampen the vicious cycle to degenerate human corneal endothelium (HCE) tissues. Design: Prospective, compar
Externí odkaz:
https://doaj.org/article/aa52be25f2df4ba9b6960edbc26679ba
Autor:
Nobuhiro Terao, Hideki Koizumi, Kentaro Kojima, Tetsuya Yamagishi, Yuji Yamamoto, Kengo Yoshii, Koji Kitazawa, Asako Hiraga, Munetoyo Toda, Shigeru Kinoshita, Chie Sotozono, Junji Hamuro
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV,
Externí odkaz:
https://doaj.org/article/96cf22a30aaf4687a79a10be48d9748d
Autor:
Naoki Okumura, Munetoyo Toda, Kohsaku Numa, John Bush, Motomu Tanaka, Noriko Koizumi, Junji Hamuro, Akihisa Yamamoto, Kojiro Imai, Shigeru Kinoshita, Hiroshi Tanaka, Chie Sotozono, Satoshi Teramukai, Morio Ueno
Publikováno v:
American Journal of Ophthalmology. 237:267-277
PURPOSE To investigate the safety and efficacy of cultured human corneal endothelial cell (hCEC)-injection therapy with mature differentiated (mature) cell subpopulations (SPs) for corneal endothelial failure (CEF). DESIGN Comparative, interventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2222ab4278a79602ae9ee7e39561ff
https://doi.org/10.1016/j.ajo.2021.11.012
https://doi.org/10.1016/j.ajo.2021.11.012
Autor:
Junji Hamuro, Kazuko Asada, Morio Ueno, Tomoko Yamashita, Atsushi Mukai, Tomoko Fujita, Eiko Ito, Nao Hiramoto, Munetoyo Toda, Chie Sotozono, Shigeru Kinoshita
Publikováno v:
Investigative ophthalmologyvisual science. 63(4)
To reveal the mechanism triggering the functional disparity between degenerated and non-degenerated corneal endothelium cells in the water efflux from corneal stroma to the anterior chamber.The varied levels of the microRNA (miR)-34, miR-378, and miR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb69bf23abcea3005efbcf1d04b7760a
https://pubmed.ncbi.nlm.nih.gov/35475886
https://pubmed.ncbi.nlm.nih.gov/35475886
Autor:
Munetoyo Toda, Koji Kitazawa, Tetsuya Yamagishi, Kengo Yoshii, Kentaro Kojima, Junji Hamuro, Chie Sotozono, Yuji Yamamoto, Hideki Koizumi, Asako Hiraga, Shigeru Kinoshita, Nobuhiro Terao
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV, 18 nAMD a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f70d0b75106ce8c1a5108005be9b589
https://doaj.org/article/96cf22a30aaf4687a79a10be48d9748d
https://doaj.org/article/96cf22a30aaf4687a79a10be48d9748d
Autor:
Michio Hagiya, Takahiro Nakamura, Munetoyo Toda, Hiroshi Tanaka, Isao Yokota, Morio Ueno, Naoki Okumura, John Bush, Junji Hamuro, Tsutomu Inatomi, Kojiro Imai, Shigeru Kinoshita, Chie Sotozono, Satoshi Teramukai, Noriko Koizumi, Yuji Yamamoto
Publikováno v:
New England Journal of Medicine. 378:995-1003
Corneal endothelial cell (CEC) disorders, such as Fuchs's endothelial corneal dystrophy, induce abnormal corneal hydration and result in corneal haziness and vision loss known as bullous keratopathy. We investigated whether injection of cultured huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d6bf54e657cc8935d2ee3d5e3a0330
https://doi.org/10.1056/nejmoa1712770
https://doi.org/10.1056/nejmoa1712770
Autor:
Junji Hamuro, Shigeru Kinoshita, Morio Ueno, Munetoyo Toda, Yoshinobu Baba, Jun Yamada, Hiroshi Yukawa
Publikováno v:
Investigative ophthalmologyvisual science. 60(12)
Purpose The injection of cultured human corneal endothelial cells (cHCECs) into the anterior chamber (AC) is a newly developed modality for the successful treatment of corneal endothelium dysfunction. Here, we investigated whether or not cHCECs could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2476ad95ad1c39323aaab21a882bb701
https://pubmed.ncbi.nlm.nih.gov/31560364
https://pubmed.ncbi.nlm.nih.gov/31560364
Autor:
Shigeru Kinoshita, Atushi Mukai, Chie Sotozono, Junji Hamuro, Morio Ueno, Yuichi Tokuda, Tomoko Fujita, Masakazu Nakano, Munetoyo Toda, Koji Ueda, Kohsaku Numa
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Aiming to clarify the metabolic interrogation in cell fate decision of cultured human corneal endothelial cells (cHCECs). Methods To analyze the metabolites in the culture supernatants (CS), 34 metabolome measurements were carried out for mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd1044aa470de3d015ab27c69c47f58
https://doi.org/10.1167/iovs.61.2.10
https://doi.org/10.1167/iovs.61.2.10