Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Muneto, Mogi"'
Autor:
Maura A Crowley, Donita L Garland, Holger Sellner, Angela Banks, Lin Fan, Tomas Rejtar, Natasha Buchanan, Omar Delgado, Yong Yao Xu, Sandra Jose, Christopher M Adams, Muneto Mogi, Karen Wang, Chad E Bigelow, Stephen Poor, Karen Anderson, Bruce D Jaffee, Ganesh Prasanna, Cynthia Grosskreutz, Rosario Fernandez-Godino, Eric A Pierce, Thaddeus P Dryja, Sha-Mei Liao
Publikováno v:
Human Molecular Genetics. 32:204-217
EFEMP1 R345W is a dominant mutation causing Doyne honeycomb retinal dystrophy/malattia leventinese (DHRD/ML), a rare blinding disease with clinical pathology similar to age-related macular degeneration (AMD). Aged Efemp1 R345W/R345W knock-in mice (Ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec58b40ea8387ba6f2edc6bd8b972d3
https://doi.org/10.1093/hmg/ddac187
https://doi.org/10.1093/hmg/ddac187
Autor:
Nello Mainolfi, Takeru Ehara, Rajeshri G. Karki, Karen Anderson, Aengus Mac Sweeney, Sha-Mei Liao, Upendra A. Argikar, Keith Jendza, Chun Zhang, James Powers, Daniel W. Klosowski, Maura Crowley, Toshio Kawanami, Jian Ding, Myriam April, Cornelia Forster, Michael Serrano-Wu, Michael Capparelli, Rrezarta Ramqaj, Catherine Solovay, Frederic Cumin, Thomas M. Smith, Luciana Ferrara, Wendy Lee, Debby Long, Melissa Prentiss, Andrea De Erkenez, Louis Yang, Fang Liu, Holger Sellner, Finton Sirockin, Eric Valeur, Paulus Erbel, Daniela Ostermeier, Paul Ramage, Bernd Gerhartz, Anna Schubart, Stefanie Flohr, Nathalie Gradoux, Roland Feifel, Barbara Vogg, Christian Wiesmann, Jürgen Maibaum, Jörg Eder, Richard Sedrani, Richard A. Harrison, Muneto Mogi, Bruce D. Jaffee, Christopher M. Adams
Publikováno v:
Journal of Medicinal Chemistry. 63:5697-5722
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::161530bd60ced781537b4b5cf97869fc
https://doi.org/10.1021/acs.jmedchem.9b01870
https://doi.org/10.1021/acs.jmedchem.9b01870
Autor:
Dean F. Rigel, Gary M. Coppola, Frederic Villard, Li Fan, Muneto Mogi, Emma Cody, Nikolaus Schiering, Guiqing Liang, Christian Wiesmann, Arco Y. Jeng, Yongjin Gong, Jing Liu, Paul Ramage, Fumin Fu, Alan D. Neubert, Yuki Iwaki, Allan D'Arcy, Qian Liu, Wei Chen, Jennifer Leung-Chu, Robert Sun, Rajeshri Ganesh Karki, Frederic Cumin, Toshio Kawanami, Gary Michael Ksander, Sara Ingles, Michael E. Beil
Publikováno v:
ACS Med Chem Lett
[Image: see text] Inhibition of neprilysin (NEP) is widely studied as a therapeutic target for the treatment of hypertension, heart failure, and kidney disease. Sacubitril/valsartan (LCZ696) is a drug approved to reduce the risk of cardiovascular dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2573c39ef5000dc9e148109a83e4e51
https://doi.org/10.1021/acsmedchemlett.9b00578
https://doi.org/10.1021/acsmedchemlett.9b00578
Autor:
John Gounarides, Jennifer S Cobb, Jing Zhou, Frank Cook, Xuemei Yang, Hong Yin, Erik Meredith, Chang Rao, Qian Huang, YongYao Xu, Karen Anderson, Andrea De Erkenez, Sha-Mei Liao, Maura Crowley, Natasha Buchanan, Stephen Poor, Yubin Qiu, Elizabeth Fassbender, Siyuan Shen, Amber Woolfenden, Amy Jensen, Rosemarie Cepeda, Bijan Etemad-Gilbertson, Shelby Giza, Muneto Mogi, Bruce Jaffee, Sassan Azarian
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111472 (2014)
Proteins that are post-translationally adducted with 2-(ω-carboxyethyl)pyrrole (CEP) have been proposed to play a pathogenic role in age-related macular degeneration, by inducing angiogenesis in a Toll Like Receptor 2 (TLR2)-dependent manner. We hav
Externí odkaz:
https://doaj.org/article/b9a79129473e414ea28609d634224ec6
Autor:
Ganesh Prasanna, Christopher Breen, Sean Kim, Jennifer L. Dumouchel, Christopher M. Adams, Muneto Mogi, Upendra A. Argikar, Takeru Ehara
MGV354 was being developed as a novel ocular therapy for lowering of intraocular pressure, a key modifiable risk factor for glaucoma. MGV354 is an activator of soluble guanylate cyclase, an enzyme known to be involved in the regulation of IOP. MGV354
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7f7727c2eac407f349460ea55f31ed
Autor:
Thomas R Walters, Jen Watts, Christopher M. Adams, James H. Peace, Cynthia L. Grosskreutz, Rebecca C. Stacy, Kenneth N Sall, Yunsheng He, Ganesh Prasanna, Xiao Ni, Jing-He Yan, John J. Seaman, Muneto Mogi, Randall Kolega, Ronald Newton, Michael Wald, David Wirta, Kenneth Huttner
Publikováno v:
American Journal of Ophthalmology. 192:113-123
Purpose To assess the clinical safety, tolerability, and efficacy of topically administered MGV354, a soluble guanylate cyclase (sGC) activator, in patients with ocular hypertension (OH) or glaucoma. Design Double-masked, randomized, and vehicle-cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a3b50017ac9dbeb738006d13fa090b
https://doi.org/10.1016/j.ajo.2018.05.015
https://doi.org/10.1016/j.ajo.2018.05.015
Autor:
Christopher M. Adams, Catherine Solovay, Muneto Mogi, Byron Li, Doug Bevan, Mitsunori Kato, Jonathan E. Grob, Erik Meredith, David B. Belanger, Powers James J, Philippe Bolduc, Louis Yang, Nan Ji, Michael Paul Capparelli, Donglei Liu, Christopher Towler, Ganesh Prasanna, Matthew H. Daniels, Takeru Ehara, Rebecca C. Stacy, Luciana Ferrara
Publikováno v:
Journal of Medicinal Chemistry. 61:2552-2570
Soluble guanylate cyclase (sGC), the endogenous receptor for nitric oxide (NO), has been implicated in several diseases associated with oxidative stress. In a pathological oxidative environment, the heme group of sGC can be oxidized becoming unrespon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c16c37de994217e68708053a88c17a0
https://doi.org/10.1021/acs.jmedchem.8b00007
https://doi.org/10.1021/acs.jmedchem.8b00007
Autor:
Muneto Mogi, Debby Long, Patrick J Rudewicz, Viral Kansara, Kerri J. Grove, Melissa Prentiss, Sean Kim
Publikováno v:
SLAS Discovery. 22:1239-1245
Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is becoming an important technology to determine the distribution of drugs and their metabolites in the tissue of preclinical species after dosing. Interest in IMS is g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41eca1ce00a7d06836c9e83cf9418a4c
https://doi.org/10.1177/2472555217724780
https://doi.org/10.1177/2472555217724780
Autor:
Anna Vulpetti, Upendra A. Argikar, Stefanie Flohr, Aengus Mac Sweeney, Melissa Prentiss, Edwige Lorthiois, Karen Anderson, David B. Belanger, Sha-Mei Liao, Nan Ji, Christopher M. Adams, Frederic Cumin, Andrea De Erkenez, Nathalie Gradoux, Muneto Mogi, Donglei Liu, Maura Crowley, Keith Jendza, Debby Long, Nello Mainolfi, Catherine Solovay, Ann Brown, Laura R. La Bonte, Rajeshri Ganesh Karki, Omar Delgado, Powers James J, Bruce D Jaffee, Christine F. Gelin
Publikováno v:
Journal of medicinal chemistry. 62(9)
Complement factor D (FD), a highly specific S1 serine protease, plays a central role in the amplification of the alternative complement pathway (AP) of the innate immune system. Dysregulation of AP activity predisposes individuals to diverse disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da588cee5e7843ba124041bcbf4f4b5e
https://pubmed.ncbi.nlm.nih.gov/30995036
https://pubmed.ncbi.nlm.nih.gov/30995036
Autor:
Mitsunori Kato, Jason Gunawan, Xiaoling Xie, Muneto Mogi, Neeraja Idamakanti, Waan-Jeng Huang, Daniel LaSala, Ken Yamada, Hajime Yoshisue, Hyi-Man Park, Zhan Deng, Darcy Kohls, Yukiko I. Yagi, David Yowe, Kayo Yasoshima, Amy Qiongshu Xie, Reinhardt Juergen, Debra Burdick, Natasha Kreder, Q. Kimberley Yue, Pramod Pandey, Peter Drueckes, Isabel Schmidt, Toshio Kawanami, Hiromichi Wakai, Ji-Hu Zhang
Publikováno v:
ACS Chemical Biology. 11:3338-3346
Protein kinases are known for their highly conserved adenosine triphosphate (ATP)-binding site, rendering the discovery of selective inhibitors a major challenge. In theory, allosteric inhibitors can achieve high selectivity by targeting less conserv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b363e34512a8c7147a1bb8f1b5e7f58f
https://doi.org/10.1021/acschembio.6b00511
https://doi.org/10.1021/acschembio.6b00511