Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Munetaka Nokubo"'
Development of Monoclonal Antibodies to the Malondialdehyde−Deoxyguanosine Adduct, Pyrimidopurinone1
Autor:
Norma H. Mahle, Naomi Eliezer, Lawrence J. Marnett, Cynthia L. Sevilla, Shawn M. O'Hara, Ryan J. Miller, Munetaka Nokubo, Adam Uzieblo, Carol A. Rouzer
Publikováno v:
Chemical Research in Toxicology. 10:172-180
Malondialdehyde (MDA), an endogenous product of lipid peroxidation and prostaglandin biosynthesis, is mutagenic in bacterial and mammalian cells and carcinogenic in rats. In order to determine whether MDA-modified bases are formed in nucleic acids in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::927a2c12b0b173101a2b27396755fc5d
https://doi.org/10.1021/tx960120d
https://doi.org/10.1021/tx960120d
Publikováno v:
Journal of Mass Spectrometry. 30:1157-1166
Endogenous carcinogens arising from normal metabolism are known to cause modifications to DNA by reacting with bases to form adducts. Malondialdehyde is a well characterized endogenous carcinogen that forms an adduct with 2′-deoxyguanosine. This ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9ddb1a1d29a8619bec9f31adbcab7b8
https://doi.org/10.1002/jms.1190300813
https://doi.org/10.1002/jms.1190300813
Publikováno v:
Life Sciences. 54:983-989
Male C57BL/6 mice were fed with normal diet (ND) or diets containing 0.3 or 0.5% ursodeoxycholic acid (UDCA) for 3 weeks. Glutathione S-transferase (GST) activities in the liver cytosolic fraction of these animals toward 1,2-dichloro,4-nitrobenzene (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f633a2557b352cfece16d592f992e1
https://doi.org/10.1016/0024-3205(94)00500-1
https://doi.org/10.1016/0024-3205(94)00500-1
Autor:
Maria-Cristina Carrillo, Setsuko Kanai, Gwen O. Ivy, Yuko Sato, Munetaka Nokubo, Kenichi Kitani
Publikováno v:
Life Sciences. 52:1925-1934
We previously reported that the optimal dosage of (−)deprenyl to increase superoxide dismutase (SOD) activities in striatum in rats differs 10 fold between young male and female rats (1). Furthermore, in female rats the optimal dosage increased wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45de7a2e865dd84c94b3dae322e502bb
https://doi.org/10.1016/0024-3205(93)90633-e
https://doi.org/10.1016/0024-3205(93)90633-e
Publikováno v:
Drug Development Research. 26:461-465
The purpose of this study was to investigate the influence of aging on the diurnal varitaion in glutathione (GSH) content of mouse liver. Young (7 months) and old (27 months) C57BL mice were housed under standarized conditions with lighting from 0800
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c066bffc1abe2ff9ab733c592496445
https://doi.org/10.1002/ddr.430260409
https://doi.org/10.1002/ddr.430260409
Publikováno v:
Biochimica et biophysica acta. 1077(3)
Enzyme activities of glutathione S-transferases (GSTs) toward five different substrates (benzalacetone (PBO), styrene oxide (STOX), sulfobromophthalein (BSP), 1,2-dichloro-4-nitrobenzene (DCNB) and 1-chloro-2,4-dinitrobenzene (CDNB)) as well as conce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1f7e52476c86584d2b50d70fe080ea
https://pubmed.ncbi.nlm.nih.gov/2029531
https://pubmed.ncbi.nlm.nih.gov/2029531
Publikováno v:
Life sciences. 48(6)
Daily s.c. injection of (−)deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused a threefold increase in superoxide dismutase (SOD) activity in the striatum of the brain compared with the value in saline-injected control rats. Furtherm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0932045d24bf681ced3c0495a1ace610
https://pubmed.ncbi.nlm.nih.gov/1899460
https://pubmed.ncbi.nlm.nih.gov/1899460
Autor:
Setsuko Kanai, Kenichi Kitani, Munetaka Nokubo, Maria-Cristina Carrillo, Minoru Ohta, Yuko Sato
Publikováno v:
Mechanisms of ageing and development. 56(3)
Female Fischer-344 rats of different ages (8 and 25 months old) were fed a protein-free diet (PFD) for 7 days and refed a normal diet (ND) (23% protein) thereafter. Rats were killed immediately after the PFD was stopped (day 0) and at different time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a64f6a1a01deb9e24315bf5de0668c5
https://pubmed.ncbi.nlm.nih.gov/2089198
https://pubmed.ncbi.nlm.nih.gov/2089198
Publikováno v:
Lipofuscin and Ceroid Pigments ISBN: 9781489953414
A "Protease inhibitor model of aging" has been proposed primarily based on observations on brain tissues exposed to a thiol protease inhibitor, leupeptin (Ivy et al., 1984a). In order to validate this model in terms of a mechanism of cellular aging,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd3270d81c5d913d7b40410b945bcecb
https://doi.org/10.1007/978-1-4899-5339-1_6
https://doi.org/10.1007/978-1-4899-5339-1_6
Publikováno v:
Lipids. 24:859-865
Hepatic biotransformation and the effect on bile flow of 7-ketolithocholic acid (7-oxo-3α-hydroxy-5β-cholan-24-oic acid), in comparison to ursodeoxycholic acid, were examined in rats under conditions of continuous infusion of solutions of sodium sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f2b8413d8400b33c1b5c34ae4b5fbd
https://doi.org/10.1007/bf02535760
https://doi.org/10.1007/bf02535760