Efficient Generation of Pancreatic Progenitor Cells from Induced Pluripotent Stem Cells Derived from a Non-Invasive and Accessible Tissue Source—The Plucked Hair Follicle

Autor: Amatullah Fatehi, Marwa Sadat, Muneera Fayyad, Jean Tang, Duhyun Han, Ian M. Rogers, Drew Taylor

Publikováno v: Cells, Vol 13, Iss 12, p 1010 (2024)

The advent of induced pluripotent stem cell (iPSC) technology has brought about transformative advancements in regenerative medicine, offering novel avenues for disease modeling, drug testing, and cell-based therapies. Patient-specific iPSC-based tre

Externí odkaz: https://doaj.org/article/06b308d1bd06420e82fa75349979ab6c

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity

Autor: Simona S. Ghanem, Nour K. Majbour, Nishant N. Vaikath, Mustafa T. Ardah, Daniel Erskine, Nanna Møller Jensen, Muneera Fayyad, Indulekha P. Sudhakaran, Eftychia Vasili, Katerina Melachroinou, Ilham Y. Abdi, Ilaria Poggiolini, Patricia Santos, Anton Dorn, Paolo Carloni, Kostas Vekrellis, Johannes Attems, Ian McKeith, Tiago F. Outeiro, Poul Henning Jensen, Omar M. A. El-Agnaf

Publikováno v: Ghanem, S S, Majbour, N K, Vaikath, N N, Ardah, M T, Erskine, D, Jensen, N M, Fayyad, M, Sudhakaran, I P, Vasili, E, Melachroinou, K, Abdi, I Y, Poggiolini, I, Santos, P, Dorn, A, Carloni, P, Vekrellis, K, Attems, J, McKeith, I, Outeiro, T F, Jensen, P H & El-Agnaf, O M A 2022, ' α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity ', PNAS (Proceedings of the National Academy of Sciences of the United States of America), vol. 119, no. 15, e2109617119 . https://doi.org/10.1073/pnas.2109617119
Proceedings of the National Academy of Sciences of the United States of America 119(15), e2109617119 (2022). doi:10.1073/pnas.2109617119

α-Synuclein (α-syn) phosphorylation at serine 129 (pS129–α-syn) is substantially increased in Lewy body disease, such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). However, the pathogenic relevance of pS129–α-syn remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba55d29b3d2b2ef5284fe1134f6d0e19
https://doi.org/10.1073/pnas.2109617119

Parkinson's disease biomarkers based on α-synuclein

Autor: Safa Salim, Muneera Fayyad, Daniel Erskine, Brit Mollenhauer, Omar M. A. El-Agnaf, Erik Stoops, Nour K. Majbour

Publikováno v: Journal of neurochemistryReferences. 150(5)

Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease and is estimated to affect approximately 1-4% of individuals aged over 60 years old. Although considerable efforts have been invested into developing d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f64a6c32ba228c381e3f4ba678b899
https://pubmed.ncbi.nlm.nih.gov/31265130

Development of Novel Diagnostic and Therapeutic Tools for Parkinson's Diseases and Related Disorders

Autor: Mercy A. Thomas, Omar M. A. El-Agnaf, Muneera Fayyad, Nour K. Majbour, Nishant N. Vaikath

Publikováno v: Qatar Foundation Annual Research Conference Proceedings Volume 2018 Issue 2.

Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease. The biggest roadblock we are facing for the cure of PD is the lack of reliable biomarkers for the disease diagnosis or progression. This is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f16e909650fcd822783ab860742250cd
https://doi.org/10.5339/qfarc.2018.hbpd471

Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review

Autor: Amin F. Majdalawieh, Muneera Fayyad

Publikováno v: International Immunopharmacology. 28:295-304

Many herbal products are now used as remedies to treat various infectious and non-infectious conditions. Even though the use of herbs and natural products is much more evident in the Eastern world, their use in Western cultures is continuously increa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8748c190e31f0cc19c7a49fb2caaad6
https://doi.org/10.1016/j.intimp.2015.06.023