Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Muneaki Kurimura"'
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100390- (2022)
Two modifications of previous procedures enabled the high-yield scalable synthesis of the pharmacologically important enantiomers of a C9-keto-5-phenylmorphan ((1R,5R)- and (1S,5S)-5-(3-methoxyphenyl)-2-methyl-2-azabicyclo[3.3.1]nonan-9-one). The use
Externí odkaz:
https://doaj.org/article/73dd035c57744f8aaacb06c43321a873
Autor:
Feng Li, Jason A. Deck, Arthur E. Jacobson, Jeffrey R. Deschamps, Kenner C. Rice, Kejun Cheng, Christina M. Dersch, Richard B. Rothman, John E. Folk, Muneaki Kurimura
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:4330-4337
N-Phenethyl-substituted ortho-a and para-a oxide-bridged phenylmorphans have been obtained through an improved synthesis and their binding affinity examined at the various opioid receptors. Although the N-phenethyl substituent showed much greater aff
Autor:
Toyoki Mori, Muneaki Kurimura, Shinohara Tomoichi, Keizo Kan, Hidenori Ogawa, Kazumi Kondo, Yoshihisa Tanada, Shigeki Nakamura, Masaru Kido, Masahiko Bando, Yoshitaka Yamamura, Takahiro Hirano, Michiaki Tominaga
Publikováno v:
Journal of Medicinal Chemistry. 45:3805-3808
The synthesis and evaluation of both the (R)- and (S)-enantioisomers about the 5-position on a tetrahydro-1H-1-benzazepine derivative were described. The absolute configuration of the (R,R)-isomer (10) was determined by X-ray crystallographic analysi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 41:1965-1970
Optically active lipopeptide derivatives have been synthesized by the use of chiral glycerol derivatives. Lipopeptide WS1279 derivatives with (R)-glycerol moieties showed a higher mitogenic activity than those with the (S)-configuration. Various N-pr
Publikováno v:
Chemical and Pharmaceutical Bulletin. 42:1709-1711
MDP and lipopeptide analog conjugates inducing HIV-derived peptide-specific antibody without adding further macromolecular carriers or adjuvants were synthesized.
Autor:
Kazumi, Kondo, Keizo, Kan, Yoshihisa, Tanada, Masahiko, Bando, Tomoichi, Shinohara, Muneaki, Kurimura, Hidenori, Ogawa, Shigeki, Nakamura, Takahiro, Hirano, Yoshitaka, Yamamura, Masaru, Kido, Toyoki, Mori, Michiaki, Tominaga
Publikováno v:
Journal of medicinal chemistry. 45(17)
The synthesis and evaluation of both the (R)- and (S)-enantioisomers about the 5-position on a tetrahydro-1H-1-benzazepine derivative were described. The absolute configuration of the (R,R)-isomer (10) was determined by X-ray crystallographic analysi
Autor:
Muneaki Kurimura, Kazuo Achiwa
Publikováno v:
Chemical and Pharmaceutical Bulletin. 41:627-629
Publikováno v:
Biologicalpharmaceutical bulletin. 17(7)
Mitogenicity and the production of tumor necrosis factor (TNF) by a chemically synthesized lipotetrapeptide analog (KAB-8), S-[2,3-bis(palmitoyloxy)-2R-propyl]-N-[(2,2,2)-trichloro- ethoxycarbonyl: Troc group]-(R)-cysteinyl-(S)-seryl-(S)-seryl-(S)-as
Publikováno v:
Chemicalpharmaceutical bulletin. 39(10)
The synthesis of optically active lipopeptide derivatives has been accomplished by the use of chiral glycerol derivatives. Lipopeptide derivatives with (R)-glycerol moieties showed higher mitogenic activities than those with the (S)-configuration. N-
Publikováno v:
Chemicalpharmaceutical bulletin. 38(4)
Newly synthesized lipopentapeptide derivatives with (R___-)-glycerol moieties showed higher mitogenic activities than those with the (S___-)-configuration.