IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2.

Autor: Hale M; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA., Netland J; Department of Immunology, University of Washington School of Medicine, Seattle, WA., Chen Y; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA., Thouvenel CD; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA., Smith KN; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA., Rich LM; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA., Vanderwall ER; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA., Miranda MC; Institute for Protein Design, University of Washington, Seattle, WA.; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA., Eggenberger J; Department of Immunology, University of Washington School of Medicine, Seattle, WA., Hao L; Department of Immunology, University of Washington School of Medicine, Seattle, WA., Watson MJ; Department of Medicinal Chemistry, University of Washington, Seattle, WA., Mundorff CC; Department of Medicinal Chemistry, University of Washington, Seattle, WA., Rodda LB; Department of Immunology, University of Washington School of Medicine, Seattle, WA., King NP; Institute for Protein Design, University of Washington, Seattle, WA.; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA., Guttman M; Department of Medicinal Chemistry, University of Washington, Seattle, WA., Gale M; Department of Immunology, University of Washington School of Medicine, Seattle, WA., Abraham J; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA., Debley JS; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA., Pepper M; Department of Immunology, University of Washington School of Medicine, Seattle, WA., Rawlings DJ; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA.; Department of Immunology, University of Washington School of Medicine, Seattle, WA.; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2022 Sep 05; Vol. 219 (9). Date of Electronic Publication: 2022 Aug 08.

TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease.

Autor: MacDonald BT; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. Electronic address: bryanmac@broadinstitute.org., Keshishian H; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Mundorff CC; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Arduini A; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Lai D; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Bendinelli K; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Popp NR; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Bhandary B; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Clauser KR; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Specht H; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Elowe NH; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Laprise D; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Xing Y; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Kaushik VK; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Carr SA; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Ellinor PT; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

Publikováno v: Molecular & cellular proteomics : MCP [Mol Cell Proteomics] 2022 Apr; Vol. 21 (4), pp. 100223. Date of Electronic Publication: 2022 Mar 11.

Cumulative deamidations of the major lens protein γS-crystallin increase its aggregation during unfolding and oxidation.

Autor: Vetter CJ; Integrative Biosciences, Oregon Health & Science University, Portland, Oregon, USA., Thorn DC; Research School of Chemistry, College of Science, The Australian National University, Acton, Australia., Wheeler SG; Integrative Biosciences, Oregon Health & Science University, Portland, Oregon, USA., Mundorff CC; Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.; Department of Chemistry & Chemical Biology, Northeastern University, Boston, Massachusetts, USA., Halverson KA; Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, Oregon, USA., Wales TE; Department of Chemistry & Chemical Biology, Northeastern University, Boston, Massachusetts, USA., Shinde UP; Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, Oregon, USA., Engen JR; Department of Chemistry & Chemical Biology, Northeastern University, Boston, Massachusetts, USA., David LL; Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, Oregon, USA., Carver JA; Research School of Chemistry, College of Science, The Australian National University, Acton, Australia., Lampi KJ; Integrative Biosciences, Oregon Health & Science University, Portland, Oregon, USA.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2020 Sep; Vol. 29 (9), pp. 1945-1963.