Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial.

Autor: Jacobs TG; Department of Pharmacy, Radboudumc Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Mumbiro V; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Cassia U; Universidade Eduardo Mondlane Faculdade de Medicina, Maputo, Mozambique., Zimba K; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia., Nalwanga D; Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda., Ballesteros A; Pediatric Unit for Research and Clinical Trials, Hospital 12 de Octubre Health Research Institute, Biomedical Foundation of Hospital Universitario 12 de Octubre, Madrid, Spain., Domínguez-Rodríguez S; Pediatric Unit for Research and Clinical Trials, Hospital 12 de Octubre Health Research Institute, Biomedical Foundation of Hospital Universitario 12 de Octubre, Madrid, Spain., Tagarro A; Pediatric Unit for Research and Clinical Trials, Hospital 12 de Octubre Health Research Institute, Biomedical Foundation of Hospital Universitario 12 de Octubre, Madrid, Spain.; Pediatric Service, Infanta Sofia University Hospital, Servicio Madrileño de Salud, Madrid, Spain.; Universidad Europea de Madrid, Madrid, Spain., Madrid L; Pediatric Unit for Research and Clinical Trials, Hospital 12 de Octubre Health Research Institute, Biomedical Foundation of Hospital Universitario 12 de Octubre, Madrid, Spain.; London School of Hygiene and Tropical Medicine, London, United Kingdom., Mutata C; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Chitsamatanga M; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Bwakura-Dangarembizi M; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Passanduca A; Universidade Eduardo Mondlane Faculdade de Medicina, Maputo, Mozambique., Buck WC; Universidade Eduardo Mondlane Faculdade de Medicina, Maputo, Mozambique.; David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA., Nduna B; Arthur Davidson Children's Hospital, Ndola, Zambia., Chabala C; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia.; School of Medicine, University of Zambia, Lusaka, Zambia.; HerpeZ, Lusaka, Zambia., Najjingo E; Mbarara Regional Referral Hospital, Mbarara, Uganda., Musiime V; Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.; Joint Clinical Research Centre, Kampala, Uganda., Moraleda C; Pediatric Unit for Research and Clinical Trials, Hospital 12 de Octubre Health Research Institute, Biomedical Foundation of Hospital Universitario 12 de Octubre, Madrid, Spain.; Pediatric Service, Hospital Universitario 12 de Octubre, Servicio Madrileño de Salud, Madrid, Spain., Colbers A; Department of Pharmacy, Radboudumc Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Mujuru HA; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Rojo P; Pediatric Unit for Research and Clinical Trials, Hospital 12 de Octubre Health Research Institute, Biomedical Foundation of Hospital Universitario 12 de Octubre, Madrid, Spain.; Pediatric Service, Hospital Universitario 12 de Octubre, Servicio Madrileño de Salud, Madrid, Spain.; Complutense University of Madrid, Madrid, Spain., Burger DM; Department of Pharmacy, Radboudumc Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2024 Mar 20; Vol. 78 (3), pp. 702-710.

First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia.

Autor: Chabala C; University of Zambia, School of Medicine, Lusaka, Zambia.; University Teaching Hospital, Children's Hospital, Lusaka, Zambia.; HerpeZ, Lusaka, Zambia., Jacobs TG; Department of Pharmacy, Radboudumc Institute for Medical Innovation (RIMI), Radboud University Medical Center, Nijmegen, The Netherlands., Moraleda C; Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O), Madrid, Spain., Ndaferankhande JM; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi., Mumbiro V; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Passanduca A; Universidade Eduardo Mondlane, Faculdade de Medicina, Maputo, Mozambique., Namuziya N; University Teaching Hospital, Children's Hospital, Lusaka, Zambia., Nalwanga D; Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda., Musiime V; Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda.; Joint Clinical Research Centre, Kampala, Uganda., Ballesteros A; Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O), Madrid, Spain., Domínguez-Rodríguez S; Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O), Madrid, Spain., Chitsamatanga M; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Cassia U; Universidade Eduardo Mondlane, Faculdade de Medicina, Maputo, Mozambique., Nduna B; Arthur Davidson Children's Hospital, Ndola, Zambia., Bramugy J; Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique., Sacarlal J; Universidade Eduardo Mondlane, Faculdade de Medicina, Maputo, Mozambique., Madrid L; Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O), Madrid, Spain.; London School of Hygiene and Tropical Medicine (LMC), London, UK., Nathoo KJ; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Colbers A; Department of Pharmacy, Radboudumc Institute for Medical Innovation (RIMI), Radboud University Medical Center, Nijmegen, The Netherlands., Burger DM; Department of Pharmacy, Radboudumc Institute for Medical Innovation (RIMI), Radboud University Medical Center, Nijmegen, The Netherlands., Mulenga V; University of Zambia, School of Medicine, Lusaka, Zambia.; University Teaching Hospital, Children's Hospital, Lusaka, Zambia., Buck WC; Universidade Eduardo Mondlane, Faculdade de Medicina, Maputo, Mozambique.; University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA., Mujuru HA; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Te Brake LHM; Department of Pharmacy, Radboudumc Institute for Medical Innovation (RIMI), Radboud University Medical Center, Nijmegen, The Netherlands., Rojo P; Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O), Madrid, Spain.; Complutense University of Madrid, Madrid, Spain.; Pediatric Service, Hospital Universitario 12 de Octubre, Servicio Madrileño de Salud (SERMAS), Madrid, Spain., Tagarro A; Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O), Madrid, Spain.; Pediatric Service, Infanta Sofia University Hospital, Servicio Madrileño de Salud (SERMAS), Madrid, Spain.; Universidad Europea de Madrid, Madrid, Spain., Aarnoutse RE; Department of Pharmacy, Radboudumc Institute for Medical Innovation (RIMI), Radboud University Medical Center, Nijmegen, The Netherlands.

Publikováno v: Journal of the Pediatric Infectious Diseases Society [J Pediatric Infect Dis Soc] 2023 Nov 30; Vol. 12 (11), pp. 581-585.

Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial.

Autor: Turkova A; Medical Research Council Clinical Trials Unit at University College London, London, UK. Electronic address: a.turkova@ucl.ac.uk., White E; Medical Research Council Clinical Trials Unit at University College London, London, UK., Kekitiinwa AR; Baylor College of Medicine, Kampala, Uganda., Mumbiro V; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Kaudha E; Joint Clinical Research Centre, Kampala, Uganda., Liberty A; Perinatal HIV Research Unit, University of the Witwarsrand, Johannesburg, South Africa., Ahimbisibwe GM; Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda., Moloantoa T; Perinatal HIV Research Unit, University of the Witwarsrand, Johannesburg, South Africa., Srirompotong U; Pediatric Department, Khon Kaen Hospital, Thailand., Mosia NR; Department of Paediatrics and Children Health, King Edward VIII Hospital, Enhancing Care Foundation, University of KwaZulu-Natal, Durban, South Africa., Puthanakit T; HIVNAT, Thai Red Cross AIDS Research Center, Bangkok, Thailand; Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Thailand., Kobbe R; Institute for Infection Research and Vaccine Development, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany; Department of Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany., Fortuny C; Infectious Diseases Department, Institut de Recerca Sant Joan de Déu, Sant Joan de Déu Children's Hospital, Barcelona, Spain; Department of Surgery and Medico-Surgical Specialties, Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain., Kataike H; Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda., Bbuye D; Baylor College of Medicine, Kampala, Uganda., Na-Rajsima S; Pediatric Department, Mahasarakam Hospital, Thailand., Coelho A; INSERM/ANRS SC10-US19, Essais Thérapeutiques et Maladies Infectieuses, Villejuif, France., Lugemwa A; Joint Clinical Research Centre, Mbarara, Uganda., Bwakura-Dangarembizi MF; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Klein N; Infection, Immunity & Inflammation Department, UCL Great Ormond Street Institute of Child Health, London, UK; Africa Health Research Institute, Kwazulu-Natal, South Africa., Mujuru HA; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Kityo C; Joint Clinical Research Centre, Kampala, Uganda., Cotton MF; Children's Infectious Diseases Clinical Research Unit, Family Center for Research with Ubuntu, Department of Paediatrics and Child Health, University of Stellenbosch, Cape Town, South Africa., Ferrand RA; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., Giaquinto C; Department of Women and Child Health, Padova, University of Padova, Italy., Rojo P; Pediatric Infectious Diseases Unit, Hospital 12 de Octubre, Madrid, Spain., Violari A; Perinatal HIV Research Unit, University of the Witwarsrand, Johannesburg, South Africa., Gibb DM; Medical Research Council Clinical Trials Unit at University College London, London, UK., Ford D; Medical Research Council Clinical Trials Unit at University College London, London, UK.

Publikováno v: The Lancet. Child & adolescent health [Lancet Child Adolesc Health] 2023 Oct; Vol. 7 (10), pp. 718-727. Date of Electronic Publication: 2023 Aug 08.

Brief Report: Suboptimal Lopinavir Exposure in Infants on Rifampicin Treatment Receiving Double-dosed or Semisuperboosted Lopinavir/Ritonavir: Time for a Change.

Autor: Jacobs TG; Department of Pharmacy, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Mumbiro V; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Chitsamatanga M; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Namuziya N; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia., Passanduca A; Universidade Eduardo Mondlane Faculdade de Medicina, Maputo, Mozambique., Domínguez-Rodríguez S; Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O), Madrid, Spain., Tagarro A; Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O), Madrid, Spain.; Pediatric Service. Infanta Sofia University Hospital, Servicio Madrileño de Salud (SERMAS), Madrid, Spain.; Universidad Europea de Madrid., Nathoo KJ; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Nduna B; Arthur Davidson Children's Hospital, Ndola, Zambia., Ballesteros A; Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O), Madrid, Spain., Madrid L; Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O), Madrid, Spain.; London School of Hygiene and Tropical Medicine (LMC), London UK., Mujuru HA; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Chabala C; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia.; University of Zambia, School of Medicine, Lusaka, Zambia., Buck WC; Universidade Eduardo Mondlane Faculdade de Medicina, Maputo, Mozambique.; University of California Los Angeles, David Geffen School of Medicine, Los Angeles, United States., Rojo P; Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O), Madrid, Spain.; Pediatric Service, Hospital Universitario 12 de Octubre, Servicio Madrileño de Salud (SERMAS), Madrid, Spain; and.; Complutense University of Madrid, Madrid, Spain., Burger DM; Department of Pharmacy, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Moraleda C; Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O), Madrid, Spain.; Complutense University of Madrid, Madrid, Spain., Colbers A; Department of Pharmacy, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Publikováno v: Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2023 May 01; Vol. 93 (1), pp. 42-46. Date of Electronic Publication: 2023 Apr 01.

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