LC-MS/MS quantification of asymmetric dimethyl arginine and symmetric dimethyl arginine in plasma using surrogate matrix and derivatization with fluorescamine.

Autor: Junnotula V; Bioanalysis, Immunogenecity & Biomarkers, IVIVT, GlaxoSmithkline Pharmaceuticals, 1250 S. Collegeville Road, Collegeville, PA 19426, USA., Jones BR; Q2 Solutions, 19 Brown Road, Ithaca, NY 14850, USA., Gorman S; Clinical Biomarkers & Translational Research, Oncology Research & Development, Glaxosmithkline Pharmaceuticals, 1250 S. Collegeville Road, Collegeville, PA 19426, USA., Shen M; Q Solutions, 19 Brown Road, Ithaca, NY 14850, USA., Mulvana D; Q Solutions, 19 Brown Road, Ithaca, NY 14850, USA.

Publikováno v: Bioanalysis [Bioanalysis] 2020 Nov; Vol. 12 (22), pp. 1607-1619. Date of Electronic Publication: 2020 Nov 05.

9th GCC closed forum: CAPA in regulated bioanalysis; method robustness, biosimilars, preclinical method validation, endogenous biomarkers, whole blood stability, regulatory audit experiences and electronic laboratory notebooks.

Autor: Hayes R; MPI Research, Mattawan, MI, USA., LeLacheur R; Agilux Laboratories, Worcester, MA, USA., Dumont I; Algorithme Pharma, Laval, QC, Canada., Couerbe P; Atlanbio, Saint-Nazaire, France., Safavi A; BioAgilytix, Durham, NC, USA., Islam R; Celerion, Lincoln, NB, USA., Pattison C; Charles River, Edinburgh, UK., Cape S; Covance, Madison, WI, USA., Rocci M; ICON, Whitesboro, NY, USA., Briscoe C; PRA Health Sciences, Lenexa, KS, USA., Cojocaru L; Tandem Labs, West Trenton, NJ, USA, currently at Covance, WestTrenton, NJ, USA., Groeber E; WIL Research, Ashland, OH, USA., Silvestro L; 3S-Pharmacological Cons. & Res. GmbH, Harpstedt, Germany., Bravo J; Agilux Laboratories, Worcester, MA, USA., Shoup R; AIT Bioscience Indianapolis, IN, USA., Verville M; Algorithme Pharma, Laval, QC, Canada., Zimmer J; Alturas Analytics, Moscow, ID, USA., Caturla MC; Anapharm Europe, Barcelona, Spain., Khadang A; Axis Clinicals, Dilworth, MN, USA., Bourdage J; BASi, West Lafayette, IN, USA., Hughes N; Bioanalytical Laboratory Services, Toronto, ON, Canada., Fatmi S; Biotrial Bioanalytical Services Inc., Laval, QC, Canada., Di Donato L; CAPRION, Montreal, QC, Canada., Sheldon C; Celerion, Lincoln, NB, USA., Keyhani A; Charles River, Senneville, QC, CAN, currently at Algorithme Pharma, Laval, QC, Canada., Satterwhite C; Charles River, Reno, NV, USA., Yu M; CIRION BioPharma Research, Laval, QC, Canada., Fiscella M; Covance, Chantilly, VA, USA., Hulse J; Eurofins Pharma Bioanalytics Services, St Charles, MO, USA., Lin ZJ; Frontage Laboratories, Inc., Exton, PA, USA., Garofolo W; Global CRO Council for Bioanalysis (GCC)., Savoie N; Global CRO Council for Bioanalysis (GCC)., Xiao YQ; Global CRO Council for Bioanalysis, Envigo, East Millstone, NJ, USA., Kurylak K; Global CRO Council for Bioanalysis, Envigo, East Millstone, NJ, USA., Harris S; Intertek USA, San Diego, CA, USA., Saxena M; Intertek USA, San Diego, CA, USA., Buonarati M; Intertek USA, San Diego, CA, USA., Lévesque A; Previously at InVentiv Health Clinical, Quebec City, QC, CAN., Boudreau N; Previously at InVentiv Health Clinical, Quebec City, QC, CAN., Lin J; CMIC, Inc., Hoffman Estates, IL, USA., Khan MU; KCAS Bioanalytical Services, Shawnee, KS, USA, currently at Alliance Pharma, Malvern, PA, USA., Ray G; KCAS Bioanalytical Services, Shawnee, KS, USA., Liu Y; KCAS Bioanalytical Services, Shawnee, KS, USA., Xu A; Keystone Bioanalytical, Inc., North Wales, PA, USA., Soni G; Lambda Therapeutic Research, Ahmedabad, India., Ward I; LGC, Fordham, UK., Kingsley C; LGC, Fordham, UK., Ritzén H; Mercodia AB, Uppsala, Sweden., Tabler E; PPD, Richmond, VA, USA., Nicholson B; PPD, Richmond, VA, USA., Bennett P; PPD, Richmond, VA, USA., van de Merbel N; PRA Health Sciences, Assen, The Netherlands., Karnik S; Pyxant Labs, Colorado Springs, CO, USA., Bouhajib M; Pharma Medica, Toronto, ON, Canada., Wieling J; QPS, Groningen, The Netherlands, currently at Antaeus Biopharma, Groningen, Netherlands., Mulvana D; Quintiles, Ithaca, NY, USA., Ingelse B; Quintiles, Oss, The Netherlands., Allen M; Tandem Labs, Durham, NC, USA, currently at Covance, Durham, NC, USA., Malone M; Worldwide Clinical Trials, Austin, TX, USA., Fang X; WuXi/XBL, 107 Morgan Lane, Plainsboro, NJ, USA.

Publikováno v: Bioanalysis [Bioanalysis] 2016 Mar; Vol. 8 (6), pp. 487-95. Date of Electronic Publication: 2016 Feb 26.

Development of a sensitive and fast UHPLC-MS/MS method for determination of clopidogrel, clopidogrel acid and clopidogrel active metabolite H4 in human plasma.

Autor: Hua W; Bioanalytical & ADME Labs, Quintiles, Ithaca, NY 14850, USA., Lesslie M; Bioanalytical & ADME Labs, Quintiles, Ithaca, NY 14850, USA., Hoffman BT; Bioanalytical & ADME Labs, Quintiles, Ithaca, NY 14850, USA., Binns C; Bioanalytical & ADME Labs, Quintiles, Ithaca, NY 14850, USA., Mulvana D; Bioanalytical & ADME Labs, Quintiles, Ithaca, NY 14850, USA.

Publikováno v: Bioanalysis [Bioanalysis] 2015; Vol. 7 (12), pp. 1471-82.

Liquid chromatographic-electrospray tandem mass spectrometric method for the simultaneous quantitation of the prodrug fosinopril and the active drug fosinoprilat in human serum

Autor: Jemal, M., Mulvana, D. E.

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications; 2000, Vol. 739 Issue: 2 p255-271, 17p

Quantitative determination of butorphanol and its metabolites in human plasma by gas chromatography-electron capture negative-ion chemical ionization mass spectrometry

Autor: Mulvana, D. E., Duncan, G. F., Shyu, W. C., Tay, L. K., Barbhaiya, R. H.

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications; 1996, Vol. 682 Issue: 2 p289-300, 12p