Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and midazolam

Autor: Muluneh M. Fashe, Taryn A. Miner, John K. Fallon, Amanda P. Schauer, Craig Sykes, Philip C. Smith, Craig R. Lee

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Introduction: Pregnancy increases the clearance of CYP3A4 substrate drugs and pregnancy-related hormones (PRHs) induce hepatic CYP3A4 expression and metabolism. However, it remains unclear to what extent the magnitude of PRH-evoked changes in hepatic

Externí odkaz: https://doaj.org/article/5bf5aea07c3d46e3afd836d8b7b04fe3

Gendered Vulnerability, Perception and Adaptation Options of Smallholder Farmers to Climate Change in Eastern Ethiopia

Autor: Mengistu M. Maja, Abdurahim A. Idiris, Aemro T. Terefe, Muluneh M. Fashe

Publikováno v: Earth Systems and Environment. 7:189-209

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d49519cd0fc8c049abf2fce59c2faf1e
https://doi.org/10.1007/s41748-022-00324-y

Sex-specific expression mechanism of hepatic estrogen inactivating enzyme and transporters in diabetic women.

Autor: Fashe M; Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Electronic address: muluneh@email.unc.edu., Yi M; Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA., Sueyoshi T; Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA., Negishi M; Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Electronic address: negishi@niehs.nih.gov.

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2021 Aug; Vol. 190, pp. 114662. Date of Electronic Publication: 2021 Jun 23.

Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver.

Autor: Yi M; Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, USA., Fashe M; Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, USA., Arakawa S; Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, USA., Moore R; Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, USA., Sueyoshi T; Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, USA., Negishi M; Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, USA. negishi@niehs.nih.gov.

Publikováno v: Scientific reports [Sci Rep] 2020 Mar 19; Vol. 10 (1), pp. 5001. Date of Electronic Publication: 2020 Mar 19.

A phosphorylation-deficient mutant of retinoid X receptor α at Thr 167 alters fasting response and energy metabolism in mice.

Autor: Sueyoshi T; Pharmacogenetics section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA. Sueyoshi@niehs.nih.gov., Sakuma T; Pharmacogenetics section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA., Shindo S; Pharmacogenetics section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA., Fashe M; Pharmacogenetics section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA., Kanayama T; Pharmacogenetics section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA., Ray M; Knockout Mouse Core, National Institute of Environmental Health Sciences, National Institutes of Health Research, Triangle Park, NC, 27709, USA., Moore R; Pharmacogenetics section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA., Negishi M; Pharmacogenetics section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.

Publikováno v: Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2019 Oct; Vol. 99 (10), pp. 1470-1483. Date of Electronic Publication: 2019 May 31.