Výsledky vyhledávání - "Mulugeta Seneshaw"

Akademický článek

Second-Harmonic Generated Quantifiable Fibrosis Parameters Provide Signatures for Disease Progression and Regression in Nonalcoholic Fatty Liver Disease

Autor: Nicole Ng, Dean Tai, Yayun Ren, Elaine Chng, Mulugeta Seneshaw, Faridoddin Mirshahi, Michael Idowu, Amon Asgharpour, Arun J Sanyal

Publikováno v: Clinical Pathology, Vol 16 (2023)

Introduction: The current ordinal fibrosis staging system for nonalcoholic steatohepatitis (NASH) has a limited dynamic range. The goal of this study was to determine if second-harmonic generated (SHG) quantifiable collagen fibrillar properties (qFP)

Externí odkaz: https://doaj.org/article/e4c3428b63914bea9230f4b666dbb83c

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Metabolic reprogramming of the intestinal microbiome with functional bile acid changes underlie the development of NAFLD

Autor: Ekaterina, Smirnova, Mark D, Muthiah, Nicole, Narayan, Mohamad S, Siddiqui, Puneet, Puri, Velimir A, Luketic, Melissa J, Contos, Michael, Idowu, Jen-Chieh, Chuang, Andrew N, Billin, Ryan S, Huss, Robert P, Myers, Sherry, Boyett, Mulugeta, Seneshaw, Hae-Ki, Min, Faridodin, Mirshahi, Arun J, Sanyal

Publikováno v: Hepatology. 76:1811-1824

Bile acids are hepatic metabolites and have many properties considered to be relevant to the pathophysiology of NAFLD. Circulating levels of the intestinal microbiome-modified bile acid deoxycholate are increased in cirrhosis.To further elucidate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e9c204e496a981fe3b9eb32acb3053
https://doi.org/10.1002/hep.32568

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Identification of a Metabolic, Transcriptomic, and Molecular Signature of Patatin‐Like Phospholipase Domain Containing 3–Mediated Acceleration of Steatohepatitis

Autor: Faridoddin Mirshahi, Sophie C. Cazanave, Prasanna K. Santhekadur, Bubu A. Banini, Divya P. Kumar, Abdul M. Oseini, Hae Ki Min, Liangsu Wang, Pierre Bedossa, Mulugeta Seneshaw, Cristina Alonso, Hong Ping Guan, Srinivas V. Koduru, Arun J. Sanyal

Publikováno v: Hepatology. 73:1290-1306

BACKGROUND AND AIMS The mechanisms by which the I148M mutant variant of the patatin-like phospholipase domain-containing 3 (PNPLA3I148M ) drives development of nonalcoholic steatohepatitis (NASH) are not known. The aim of this study was to obtain ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::230a2349a46562bcb088f20fd22afdeb
https://doi.org/10.1002/hep.31609

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Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated Carcinogenesis

Autor: Leandro Jimenez, Igor P. Pogribny, Arun J. Sanyal, Mulugeta Seneshaw, Volodymyr Tryndyak, Stepan Melnyk, F. Mirshahi, Aline de Conti, Barbara Borowa-Mazgaj, Frederick A. Beland, Ivan Rusyn, Colleen R Steward

Publikováno v: Toxicol Sci

Nonalcoholic fatty liver disease (NAFLD) is becoming a major etiological risk factor for hepatocellular carcinoma (HCC) in the United States and other Western countries. In this study, we investigated the role of gene-specific promoter cytosine DNA m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ce6d0a8d1b47cbe3cb7a195499e39f
https://doi.org/10.1093/toxsci/kfz110

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Author Correction: The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease

Autor: Andrea L. Webber, Kristian K. Jensen, Arun J. Sanyal, Robert Vincent, Alexei A. Podtelezhnikov, Bubu A. Banini, Divya P. Kumar, Hae-Ki Min, Keith Q. Tanis, Sophie C. Cazanave, Prasanna K. Santhekadur, Abdul M. Oseini, Faridoddin Mirshahi, Liangsu Wang, Adolfo G Mauro, Mulugeta Seneshaw, Pierre Bedossa

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)

A longitudinal molecular model of the development and progression of nonalcoholic fatty liver disease (NAFLD) over time is lacking. We have recently validated a high fat/sugar water-induced animal (an isogenic strain of C57BL/6 J:129S1/SvImJ mice) mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a80a8ccf95afc52cda74aa8366fb716
http://europepmc.org/articles/PMC7225167

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The multifaceted role of natriuretic peptides in metabolic syndrome

Autor: Mulugeta Seneshaw, Faridoddin Mirshahi, Divya P. Kumar, Arun J. Sanyal, Prasanna K. Santhekadur

Due to globalization and sophisticated western and sedentary lifestyle, metabolic syndrome has emerged as a serious public health challenge. Obesity is significantly increasing worldwide because of increased high calorie food intake and decreased phy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61aaf02ee5764b2a169e035b33363014
https://europepmc.org/articles/PMC5737745/

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Fast and Simplified Method for High Through-put Isolation of miRNA from Highly Purified High Density Lipoprotein

Autor: Kalyani Daita, Shervin Mirshahi, Arun J. Sanyal, Hae-Ki Min, Faridoddin Mirshahi, Michael Fuchs, Amon Asgharpour, Mulugeta Seneshaw, Sherry Boyett, Prasanna K. Santhekadur

Publikováno v: Journal of Visualized Experiments.

Small non-coding RNAs (miRNAs) have been implicated in a variety of human diseases including metabolic syndromes. They may be utilized as biomarkers for diagnosis and prognosis or may serve as targets for drug development, respectively. Recently it h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4514260a06b975de1223c97781429c7d
https://doi.org/10.3791/54257-v

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Abstract 5323: Gene-specific DNA methylation alterations in non-alcoholic fatty liver disease (NAFLD)-derived hepatocellular carcinoma in mice

Autor: Frederick A. Beland, Aline de Conti, Arun J. Sanyal, Igor P. Pogribny, F. Mirshahi, Barbara Borowa-Mazgaj, Mulugeta Seneshaw

Publikováno v: Cancer Research. 78:5323-5323

Hepatocellular carcinoma (HCC) ranks as one of the most aggressive human cancers, with a steadily increasing incidence in the United States and worldwide. HCC is a disease characterized by the presence of multiple heritable cellular, molecular, and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::422cd7ce320fb2c5828435f5dba4eaa6
https://doi.org/10.1158/1538-7445.am2018-5323

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