Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Multifactorial Inheritance/genetics"'
Autor:
Lin, Bochao D., Pinzón-Espinosa, Justo, Blouzard, Elodie, Van Der Horst, Marte Z., Okhuijsen-pfeifer, Cynthia, Van Eijk, Kristel R., Guloksuz, Sinan, Peyrot, Wouter J., Luykx, Jurjen J., Hasan, Alkomiet, Wagner, Elias, Pantelis, Christos, Everall, Ian P., Ayhan, Y., Babaoğlu, M. O., Bak, Maarten, Alink, Wouter, Beld, E, Bouhuis, A, Edlinger, M, Erdoğan, I .m., Gutwinski, Stefan, Hallikainen, Tero, Jeger-land, E, Lähteenvuo, Markku, De Koning, Mariken B., Morgenroth, Carla, Müderrisoğlu, A., Oviedo-salcedo, Tatiana, Schreiter, Stefanie, Repo-tiihonen, Eila, Tuppurainen, Heli, Veereschild, Mike, Veerman, Selene R.t., Cohen, Dan, De Vos, M, Bogers, Jan P.a.m., Anıl Yağcıoğlu, A.e., Tiihonen, Jari, Ripke, Stephan, Bousman, Chad A., Van Beek, H, Van Der Horst, Marte, Van Eijk, Kristel, Ertuğrul, A., Yoca, G., Görlitz, T., Grootens, K., Leucht, Stefan, Narang, A., Schneider-thoma, J., Kahn, René S., Bekema, Erwin, Kleymann, Phillip, Alizadeh, Behrooz Z., Van Amelsvoort, Therese, Cahn, Wiepke, De Haan, Lieuwe, Schirmbeck, Frederike, Simons, Claudia J.p., Van Os, Jim, Rutten, Bart, Van Winkel, Ruud
Publikováno v:
JAMA Psychiatry. American Medical Association
Genetic Risk and Outcome of Psychosis (GROUP) and Clozapine International Consortium (CLOZIN) Investigators 2023, ' Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia ', JAMA Psychiatry, vol. 80, no. 2, pp. 181-185 . https://doi.org/10.1001/jamapsychiatry.2022.4234
JAMA psychiatry, 80(2), 181-185. American Medical Association
JAMA Psychiatry, 80(2), 181-185. American Medical Association
Genetic Risk and Outcome of Psychosis (GROUP) and Clozapine International Consortium (CLOZIN) Investigators 2023, ' Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia ', JAMA psychiatry, vol. 80, no. 2, pp. 181-185 . https://doi.org/10.1001/jamapsychiatry.2022.4234
Genetic Risk and Outcome of Psychosis (GROUP) and Clozapine International Consortium (CLOZIN) Investigators 2023, ' Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia ', JAMA Psychiatry, vol. 80, no. 2, pp. 181-185 . https://doi.org/10.1001/jamapsychiatry.2022.4234
JAMA psychiatry, 80(2), 181-185. American Medical Association
JAMA Psychiatry, 80(2), 181-185. American Medical Association
Genetic Risk and Outcome of Psychosis (GROUP) and Clozapine International Consortium (CLOZIN) Investigators 2023, ' Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia ', JAMA psychiatry, vol. 80, no. 2, pp. 181-185 . https://doi.org/10.1001/jamapsychiatry.2022.4234
ImportancePredictors consistently associated with psychosis liability and course of illness in schizophrenia (SCZ) spectrum disorders (SSD), including the need for clozapine treatment, are lacking. Longitudinally ascertained medication use may empowe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b30808f0062dc9476f2ac63918f219
http://www.scopus.com/inward/record.url?scp=85147317982&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85147317982&partnerID=8YFLogxK
Autor:
Darst, Burcu F, Shen, Jiayi, Madduri, Ravi K, Rodriguez, Alexis A, Xiao, Yukai, Sheng, Xin, Saunders, Edward J, Dadaev, Tokhir, Brook, Mark N, Hoffmann, Thomas J, Muir, Kenneth, Wan, Peggy, Le Marchand, Loic, Wilkens, Lynne, Wang, Ying, Schleutker, Johanna, MacInnis, Robert J, Cybulski, Cezary, Neal, David E, Nordestgaard, Børge G, Nielsen, Sune F, Batra, Jyotsna, Clements, Judith A, Cancer BioResource, Australian Prostate, Grönberg, Henrik, Pashayan, Nora, Travis, Ruth C, Park, Jong Y, Albanes, Demetrius, Weinstein, Stephanie, Mucci, Lorelei A, Hunter, David J, Penney, Kathryn L, Tangen, Catherine M, Hamilton, Robert J, Parent, Marie-Élise, Stanford, Janet L, Koutros, Stella, Wolk, Alicja, Sørensen, Karina D, Blot, William J, Yeboah, Edward D, Mensah, James E, Lu, Yong-Jie, Schaid, Daniel J, Thibodeau, Stephen N, West, Catharine M, Maier, Christiane, Kibel, Adam S, Cancel-Tassin, Géraldine
Publikováno v:
Darst, B F, Shen, J, Madduri, R K, Rodriguez, A A, Xiao, Y, Sheng, X, Saunders, E J, Dadaev, T, Brook, M N, Hoffmann, T J, Muir, K, Wan, P, Le Marchand, L, Wilkens, L, Wang, Y, Schleutker, J, MacInnis, R J, Cybulski, C, Neal, D E, Nordestgaard, B G, Nielsen, S F, Batra, J, Clements, J A, Cancer BioResource, A P, Grönberg, H, Pashayan, N, Travis, R C, Park, J Y, Albanes, D, Weinstein, S, Mucci, L A, Hunter, D J, Penney, K L, Tangen, C M, Hamilton, R J, Parent, M-É, Stanford, J L, Koutros, S, Wolk, A, Sørensen, K D, Blot, W J, Yeboah, E D, Mensah, J E, Lu, Y-J, Schaid, D J, Thibodeau, S N, West, C M, Maier, C, Kibel, A S, Cancel-Tassin, G & NC-LA PCaP Investigators 2023, ' Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry ', American Journal of Human Genetics, vol. 110, no. 7, pp. 1200-1206 . https://doi.org/10.1016/j.ajhg.2023.05.010
Genome-wide polygenic risk scores (GW-PRSs) have been reported to have better predictive ability than PRSs based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several GW-PRS approaches to a recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pure_au_____::03f8440b5ae9ee3a0dc327cf82685214
https://pure.au.dk/portal/da/publications/evaluating-approaches-for-constructing-polygenic-risk-scores-for-prostate-cancer-in-men-of-african-and-european-ancestry(a1c60cef-54fc-4c5d-ad22-bb6121814d39).html
https://pure.au.dk/portal/da/publications/evaluating-approaches-for-constructing-polygenic-risk-scores-for-prostate-cancer-in-men-of-african-and-european-ancestry(a1c60cef-54fc-4c5d-ad22-bb6121814d39).html
Autor:
Yi Ding, Kangcheng Hou, Ziqi Xu, Aditya Pimplaskar, Ella Petter, Kristin Boulier, Florian Privé, Bjarni J. Vilhjálmsson, Loes M. Olde Loohuis, Bogdan Pasaniuc
Publikováno v:
Nature, vol 618, iss 7966
Ding, Y, Hou, K, Xu, Z, Pimplaskar, A, Petter, E, Boulier, K, Privé, F, Vilhjálmsson, B J, Olde Loohuis, L M & Pasaniuc, B 2023, ' Polygenic scoring accuracy varies across the genetic ancestry continuum ', Nature, vol. 618, pp. 774-781 . https://doi.org/10.1038/s41586-023-06079-4
Ding, Y, Hou, K, Xu, Z, Pimplaskar, A, Petter, E, Boulier, K, Privé, F, Vilhjálmsson, B J, Olde Loohuis, L M & Pasaniuc, B 2023, ' Polygenic scoring accuracy varies across the genetic ancestry continuum ', Nature, vol. 618, pp. 774-781 . https://doi.org/10.1038/s41586-023-06079-4
Polygenic scores (PGSs) have limited portability across different groupings of individuals (for example, by genetic ancestries and/or social determinants of health), preventing their equitable use1–3. PGS portability has typically been assessed usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228435a6191fd5baceca508fb65d8edf
https://escholarship.org/uc/item/4m17p3jq
https://escholarship.org/uc/item/4m17p3jq
Autor:
Gao, Guimin, Zhao, Fangyuan, Ahearn, Thomas U, Lunetta, Kathryn L, Troester, Melissa A, Du, Zhaohui, Ogundiran, Temidayo O, Ojengbede, Oladosu, Blot, William, Nathanson, Katherine L, Domchek, Susan M, Nemesure, Barbara, Hennis, Anselm, Ambs, Stefan, McClellan, Julian, Nie, Mark, Bertrand, Kimberly, Zirpoli, Gary, Yao, Song, Olshan, Andrew F, Bensen, Jeannette T, Bandera, Elisa V, Nyante, Sarah, Conti, David V, Press, Michael F, Ingles, Sue A, John, Esther M, Bernstein, Leslie, Hu, Jennifer J, Deming-Halverson, Sandra L, Chanock, Stephen J, Ziegler, Regina G, Rodriguez-Gil, Jorge L, Sucheston-Campbell, Lara E, Sandler, Dale P, Taylor, Jack A, Kitahara, Cari M, O’Brien, Katie M, Bolla, Manjeet K, Dennis, Joe, Dunning, Alison M, Easton, Douglas F, Michailidou, Kyriaki, Pharoah, Paul D P, Wang, Qin, Figueroa, Jonine, Biritwum, Richard, Adjei, Ernest, Wiafe, Seth, Ambrosone, Christine B, Zheng, Wei, Olopade, Olufunmilayo I, García-Closas, Montserrat, Palmer, Julie R, Haiman, Christopher A, Huo, Dezheng
Publikováno v:
Hum Mol Genet
Gao, G, Zhao, F, Ahearn, T U, Lunetta, K L, Troester, M A, Du, Z, Ogundiran, T O, Ojengbede, O, Blot, W, Nathanson, K L, Domchek, S M, Nemesure, B, Hennis, A, Ambs, S, Mcclellan, J, Nie, M, Bertrand, K, Zirpoli, G, Yao, S, Olshan, A F, Bensen, J T, Bandera, E V, Nyante, S, Conti, D V, Press, M F, Ingles, S A, John, E M, Bernstein, L, Hu, J J, Deming-halverson, S L, Chanock, S J, Ziegler, R G, Rodriguez-gil, J L, Sucheston-campbell, L E, Sandler, D P, Taylor, J A, Kitahara, C M, O’brien, K M, Bolla, M K, Dennis, J, Dunning, A M, Easton, D F, Michailidou, K, Pharoah, P D P, Wang, Q, Figueroa, J, Biritwum, R, Adjei, E, Wiafe, S, Ambrosone, C B, Zheng, W, Olopade, O I, García-closas, M, Palmer, J R, Haiman, C A & Huo, D 2022, ' Polygenic Risk Scores for Prediction of Breast Cancer Risk in Women of African Ancestry : a Cross-Ancestry Approach ', Human Molecular Genetics, vol. 31, no. 18, pp. 3133-3143 . https://doi.org/10.1093/hmg/ddac102
Gao, G, Zhao, F, Ahearn, T U, Lunetta, K L, Troester, M A, Du, Z, Ogundiran, T O, Ojengbede, O, Blot, W, Nathanson, K L, Domchek, S M, Nemesure, B, Hennis, A, Ambs, S, Mcclellan, J, Nie, M, Bertrand, K, Zirpoli, G, Yao, S, Olshan, A F, Bensen, J T, Bandera, E V, Nyante, S, Conti, D V, Press, M F, Ingles, S A, John, E M, Bernstein, L, Hu, J J, Deming-halverson, S L, Chanock, S J, Ziegler, R G, Rodriguez-gil, J L, Sucheston-campbell, L E, Sandler, D P, Taylor, J A, Kitahara, C M, O’brien, K M, Bolla, M K, Dennis, J, Dunning, A M, Easton, D F, Michailidou, K, Pharoah, P D P, Wang, Q, Figueroa, J, Biritwum, R, Adjei, E, Wiafe, S, Ambrosone, C B, Zheng, W, Olopade, O I, García-closas, M, Palmer, J R, Haiman, C A & Huo, D 2022, ' Polygenic Risk Scores for Prediction of Breast Cancer Risk in Women of African Ancestry : a Cross-Ancestry Approach ', Human Molecular Genetics, vol. 31, no. 18, pp. 3133-3143 . https://doi.org/10.1093/hmg/ddac102
Polygenic risk scores (PRSs) are useful for predicting breast cancer risk, but the prediction accuracy of existing PRSs in women of African ancestry (AA) remains relatively low. We aim to develop optimal PRSs for the prediction of overall and estroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5190aabf731b674db5f93e178b8d40
https://doi.org/10.1093/hmg/ddac102
https://doi.org/10.1093/hmg/ddac102
Autor:
Sigurdsson, Arnór I, Louloudis, Ioannis, Banasik, Karina, Westergaard, David, Winther, Ole, Lund, Ole, Ostrowski, Sisse Rye, Erikstrup, Christian, Pedersen, Ole Birger Vesterager, Nyegaard, Mette, Brunak, Søren, Vilhjálmsson, Bjarni J, Rasmussen, Simon
Publikováno v:
Sigurdsson, A I, Louloudis, I, Banasik, K, Westergaard, D, Winther, O, Lund, O, Ostrowski, S R, Erikstrup, C, Pedersen, O B, Nyegaard, M, Brunak, S, Vilhjálmsson, BJ & Rasmussen, S 2023, ' Deep integrative models for large-scale human genomics ', Nucleic Acids Symposium Series, vol. 51, no. 12 . https://doi.org/10.1093/nar/gkad373
Sigurdsson, A I, Louloudis, I, Banasik, K, Westergaard, D, Winther, O, Lund, O, Ostrowski, S R, Erikstrup, C, Pedersen, O B V, Nyegaard, M, Brunak, S, Vilhjálmsson, B J, Rasmussen, S & DBDS Genomic Consortium 2023, ' Deep integrative models for large-scale human genomics ', Nucleic Acids Research, vol. 51, no. 12, e67 . https://doi.org/10.1093/nar/gkad373
Sigurdsson, A I, Louloudis, I, Banasik, K, Westergaard, D, Winther, O, Lund, O, Ostrowski, S R, Erikstrup, C, Pedersen, O B V, Nyegaard, M, DBDS Genomic Consortium, Brunak, S, Vilhjálmsson, B J & Rasmussen, S 2023, ' Deep integrative models for large-scale human genomics ', Nucleic Acids Research . https://doi.org/10.1093/nar/gkad373
Sigurdsson, A I, Louloudis, I, Banasik, K, Westergaard, D, Winther, O, Lund, O, Ostrowski, S R, Erikstrup, C, Pedersen, O B V, Nyegaard, M, Brunak, S, Vilhjálmsson, B J, Rasmussen, S & DBDS Genomic Consortium 2023, ' Deep integrative models for large-scale human genomics ', Nucleic Acids Research, vol. 51, no. 12, e67 . https://doi.org/10.1093/nar/gkad373
Sigurdsson, A I, Louloudis, I, Banasik, K, Westergaard, D, Winther, O, Lund, O, Ostrowski, S R, Erikstrup, C, Pedersen, O B V, Nyegaard, M, DBDS Genomic Consortium, Brunak, S, Vilhjálmsson, B J & Rasmussen, S 2023, ' Deep integrative models for large-scale human genomics ', Nucleic Acids Research . https://doi.org/10.1093/nar/gkad373
Polygenic risk scores (PRSs) are expected to play a critical role in precision medicine. Currently, PRS predictors are generally based on linear models using summary statistics, and more recently individual-level data. However, these predictors mainl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6a28941de98e42d171caae4ffe1df592
https://curis.ku.dk/portal/da/publications/deep-integrative-models-for-largescale-human-genomics(a4bff776-9143-4f4b-8cdb-ec9d06cabedc).html
https://curis.ku.dk/portal/da/publications/deep-integrative-models-for-largescale-human-genomics(a4bff776-9143-4f4b-8cdb-ec9d06cabedc).html
Autor:
Wesseldijk, Laura W., Abdellaoui, Abdel, Gordon, Reyna L., Aslibekyan, Stella, Auton, Adam, Babalola, Elizabeth, Bell, Robert K., Bielenberg, Jessica, Bryc, Katarzyna, Bullis, Emily, Coker, Daniella, Partida, Gabriel Cuellar, Dhamija, Devika, Das, Sayantan, Elson, Sarah L., Filshtein, Teresa, Fletez-Brant, Kipper, Fontanillas, Pierre, Freyman, Will, Faaborg, Anna, Fuller, Shirin T., Gandhi, Pooja M., Heilbron, Karl, Hicks, Barry, Jewett, Ethan M., Kukar, Katelyn, Lin, Keng-Han, Lowe, Maya, McCreight, Jey C., McIntyre, Matthew H., Micheletti, Steven J., Moreno, Meghan E., Mountain, Joanna L., Nandakumar, Priyanka, Noblin, Elizabeth S., O’Connell, Jared, Huang, Yunru, Petrakovitz, Aaron A., Lane, Vanessa, Petrakovitz, Aaron, Kim, Joanne S., Poznik, G. David, Schumacher, Morgan, Shastri, Anjali J., Shelton, Janie F., Shi, Jingchunzi, Shringarpure, Suyash, Tran, Vinh, Tung, Joyce Y., Wang, Xin, Wang, Wei, Weldon, Catherine H., Wilton, Peter, Hernandez, Alejandro, Wong, Corinna, Tchakouté, Christophe Toukam, Ullén, Fredrik, Mosing, Miriam A.
Publikováno v:
23Andme Research Team 2022, ' Using a polygenic score in a family design to understand genetic influences on musicality ', Scientific Reports, vol. 12, no. 1, 14658, pp. 14658 . https://doi.org/10.1038/s41598-022-18703-w
Scientific Reports
Scientific reports, 12(1):14658. Nature Publishing Group
Scientific Reports, 12(1). Nature Publishing Group
Scientific Reports, 12(1):14658. Nature Publishing Group
Scientific Reports
Scientific reports, 12(1):14658. Nature Publishing Group
Scientific Reports, 12(1). Nature Publishing Group
Scientific Reports, 12(1):14658. Nature Publishing Group
To further our understanding of the genetics of musicality, we explored associations between a polygenic score for self-reported beat synchronization ability (PGSrhythm) and objectively measured rhythm discrimination, as well as other validated music
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4cec796660e04b70184c597982c7af
https://hdl.handle.net/1871.1/36018e9f-e714-4a73-a9c7-e0feeac3fc1b
https://hdl.handle.net/1871.1/36018e9f-e714-4a73-a9c7-e0feeac3fc1b
Autor:
Hess, Jonathan L, Tylee, Daniel S, Mors, Ole, Duan, Jubao, Dudbridge, Frank, Duncanson, Audrey, Durmishi, Naser, Edkins, Sarah, Ehrenreich, Hannelore, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Esko, Tõnu, Nordentoft, Merete, Essioux, Laurent, Fanous, Ayman H, Farh, Kai-How, Farrell, Martilias S, Frank, Josef, Franke, Lude, Freedman, Robert, Freeman, Colin, Freimer, Nelson B, Friedl, Marion, Hougaard, David M, Friedman, Joseph I, Fromer, Menachem, Gejman, Pablo V, Genovese, Giulio, Georgieva, Lyudmila, Giannoulatou, Eleni, Giegling, Ina, Gill, Michael, Gillman, Matthew, Giusti-Rodríguez, Paola, Byberg-Grauholm, Jonas, Godard, Stephanie, Goldstein, Jacqueline I, Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, Gray, Emma, Gurling, Hugh, Gwilliam, Rhian, de Haan, Lieuwe, Hall, Jeremy, Bækvad-Hansen, Marie, Hammer, Christian, Hammond, Naomi, Hamshere, Marian L, Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M, Hellenthal, Garrett, Henskens, Frans A, Herms, Stefan, Greenwood, Tiffany A, Hirschhorn, Joel N, Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V, Huang, Hailiang, Hultman, Christina M, Hunt, Sarah E, Ikeda, Masashi, Iwata, Nakao, Iyegbe, Conrad, Tsuang, Ming T, Jablensky, Assen V, Jankowski, Janusz, Jayakumar, Alagurevathi, Joa, Inge, Jönsson, Erik G, Julià, Antonio, Kähler, Anna K, Kahn, René S, Kalaydjieva, Luba, Karachanak-Yankova, Sena, Curtis, David, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C, Kendler, Kenneth S, Kennedy, James L, Khrunin, Andrey, Kim, Yunjung, Kirov, George, Klovins, Janis, Knight, Jo, Steinberg, Stacy, Knowles, James A, Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Langford, Cordelia, Laurent, Claudine, Lawrie, Stephen, Lee, S Hong, Lee, Phil, Sigurdsson, Engilbert, Lee, Jimmy, Legge, Sophie E, Lencz, Todd, Lerer, Bernard, Levinson, Douglas F, Lewis, Cathryn M, Li, Tao, Li, Qingqin S, Li, Miaoxin, Liang, Kung-Yee, Mattheisen, Manuel, Stefánsson, Hreinn, Liddle, Jennifer, Lieberman, Jeffrey, Limborska, Svetlana, Lin, Kuang, Linszen, Don H, Liu, Jianjun, Lönnqvist, Jouko, Loughland, Carmel M, Lubinski, Jan, Macek, Milan, Stefánsson, Kári, Magnusson, Patrik K E, Maher, Brion S, Maier, Wolfgang, Malhotra, Anil K, Mallet, Jacques, Markus, Hugh S, Marsal, Sara, Mata, Ignacio, Mathew, Christopher G, Mattingsdal, Morten, Edenberg, Howard J, McCann, Owen T, McCarley, Robert W, McCarroll, Steven A, McCarthy, Mark I, McDonald, Colm, McIntosh, Andrew M, McQuillin, Andrew, Meier, Sandra, Meijer, Carin J, Melegh, Bela, Holmans, Peter, Melle, Ingrid, Mesholam-Gately, Raquelle I, Metspalu, Andres, Michie, Patricia T, Milani, Lili, Milanova, Vihra, Mokrab, Younes, Moran, Jennifer L, Morris, Derek W, Mowry, Bryan J, Faraone, Stephen V, Müller-Myhsok, Bertram, Murphy, Kieran C, Murray, Robin M, Myin-Germeys, Inez, Neale, Benjamin M, Nelis, Mari, Nenadic, Igor, Nertney, Deborah A, Nestadt, Gerald, Nicodemus, Kristin K, Glatt, Stephen J, Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, Nöthen, Markus M, O'Callaghan, Eadbhard, O'Donovan, Michael C, O'Dushlaine, Colm, O'Neill, F Anthony, Oh, Sang-Yun, Olincy, Ann, Adolfsson, Rolf, Olsen, Line, Ophoff, Roel A, Van Os, Jim, Owen, Michael J, Palmer, Colin N A, Palotie, Aarno, Pantelis, Christos, Papadimitriou, George N, Papiol, Sergi, Parkhomenko, Elena, Agartz, Ingrid, Pato, Michele T, Pato, Carlos N, Paunio, Tiina, Pearson, Richard, Cairns, Murray J, DeLisi, Lynn E, Gershon, Elliot S, Kelly, Brian J, Lam, Max, Norgren, Nina, Agerbo, Esben, Paciga, Sara A, Tooney, Paul A, Wu, Jing Qin, Pejovic-Milovancevic, Milica, Perkins, Diana O, Pers, Tune H, Petryshen, Tracey L, Pietiläinen, Olli, Pimm, Jonathan, Pirinen, Matti, Albus, Margot, Plomin, Robert, Pocklington, Andrew J, Posthuma, Danielle, Potter, Simon C, Powell, John, Price, Alkes, Pulver, Ann E, Purcell, Shaun M, Quested, Digby, Rasmussen, Henrik B, Consortium, Schizophrenia Working Group of the Psychiatric Genomics, Alexander, Madeline, Rautanen, Anna, Ravindrarajah, Radhi, Reichenberg, Abraham, Reimers, Mark A, Richards, Alexander L, Ricketts, Michelle, Rietschel, Marcella, Riley, Brien P, Ripke, Stephan, Roffman, Joshua L, Amin, Farooq, Roussos, Panos, Ruderfer, Douglas M, Rujescu, Dan, Salomaa, Veikko, Sanders, Alan R, Sawcer, Stephen J, Schall, Ulrich, Schubert, Christian R, Schulze, Thomas G, Schwab, Sibylle G, Andreassen, Ole A, Scolnick, Edward M, Scott, Rodney J, Seidman, Larry J, Sham, Pak C, Shi, Jianxin, Silagadze, Teimuraz, Silverman, Jeremy M, Sim, Kang, Sklar, Pamela, Arranz, Maria J, Slominsky, Petr, Smoller, Jordan W, So, Hon-Cheong, Söderman, Erik, Spencer, Chris C A, Clair, David St, Stahl, Eli A, Stogmann, Elisabeth, Strange, Amy, Straub, Richard E, Bacanu, Silviu A, Strengman, Eric, Strohmaier, Jana, Stroup, T Scott, Su, Zhan, Subramaniam, Mythily, Sullivan, Patrick F, Suvisaari, Jaana, Svrakic, Dragan M, Szatkiewicz, Jin P, Tashakkori-Ghanbaria, Avazeh, Bakker, Steven, Thirumalai, Srinivas, Toncheva, Draga, Tosato, Sarah, Trembath, Richard C, Veijola, Juha, Visscher, Peter M, Viswanathan, Ananth C, Vukcevic, Damjan, Waddington, John, Waller, Matthew, Band, Gavin, Walsh, Dermot, Walshe, Muriel, Walters, James T R, Wang, Qiang, Wang, Dai, Webb, Bradley T, Weinberger, Daniel R, Weisbrod, Matthias, Weiser, Mark, Wendland, Jens R, Barroso, Ines, Weston, Paul, Whittaker, Pamela, Widaa, Sara, Wiersma, Durk, Wildenauer, Dieter B, Williams, Stephanie, Williams, Nigel M, Witt, Stephanie H, Wolen, Aaron R, Wong, Emily H M, Begemann, Martin, Wood, Nicholas W, Wormley, Brandon K, Wray, Naomi R, Xi, Hualin Simon, Zai, Clement C, Zheng, Xuebin, Zimprich, Fritz, Bellenguez, Céline, Research, Lundbeck Foundation Initiative for Integrative Psychiatric, Belliveau, Richard A, Bender, Stephan, Bene, Judit, Bergen, Sarah E, Bevilacqua, Elizabeth, Bigdeli, Tim B, Black, Donald W, Blackburn, Hannah, Blackwell, Jenefer M, Blackwood, Douglas H R, Børglum, Anders D, Bramon, Elvira, Brown, Matthew A, Bruggeman, Richard, Buccola, Nancy G, Buckner, Randy L, Bulik-Sullivan, Brendan, Bumpstead, Suzannah J, Buxbaum, Joseph D, Byerley, William, Cahn, Wiepke, Als, Thomas D, Cai, Guiqing, Campion, Dominique, Cantor, Rita M, Carr, Vaughan J, Carrera, Noa, Casas, Juan P, Catts, Stanley V, Chambert, Kimberley D, Chan, Ronald Y L, Chan, Raymond C K, Grove, Jakob, Chen, Eric Y H, Cheng, Wei, Cheung, Eric F C, Chong, Siow Ann, Cichon, Sven, Cloninger, C Robert, Cohen, David, Cohen, Nadine, Collier, David A, Cormican, Paul, Werge, Thomas, Corvin, Aiden, Craddock, Nick, Crespo-Facorro, Benedicto, Crowley, James J, Daly, Mark J, Darvasi, Ariel, Davidson, Michael, Davis, Kenneth L, Degenhardt, Franziska, Del Favero, Jurgen, Mortensen, Preben Bo, Deloukas, Panos, Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Domenici, Enrico, Donnelly, Peter, Donohoe, Gary, Drapeau, Elodie, Dronov, Serge
Publikováno v:
Hess, J L, Tylee, D S, Mattheisen, M, Børglum, A D, Als, T D, Grove, J, Werge, T, Mortensen, P B, Mors, O, Nordentoft, M, Hougaard, D M, Byberg-Grauholm, J, Bækvad-Hansen, M, Greenwood, T A, Tsuang, M T, Curtis, D, Steinberg, S, Sigurdsson, E, Stefánsson, H, Stefánsson, K, Edenberg, H J, Holmans, P, Faraone, S V, Glatt, S J, Schizophrenia Working Group of the Psychiatric Genomics Consortium & Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH) 2021, ' A polygenic resilience score moderates the genetic risk for schizophrenia ', Molecular Psychiatry, vol. 26, no. 3, pp. 800-815 . https://doi.org/10.1038/s41380-019-0463-8
Schizophrenia Working Group of the Psychiatric Genomics Consortium 2019, ' A polygenic resilience score moderates the genetic risk for schizophrenia ', Molecular Psychiatry . https://doi.org/10.1038/s41380-019-0463-8
Molecular psychiatry 26, 800–815 (2021). doi:10.1038/s41380-019-0463-8
Molecular psychiatry
Molecular psychiatry, 26, 800-815. Nature Publishing Group
Hess, J L, Tylee, D S, Mattheisen, M, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Børglum, A D, Als, T D, Grove, J, Werge, T, Mortensen, P B, Mors, O, Nordentoft, M, Hougaard, D M, Byberg-Grauholm, J, Bækvad-Hansen, M, Greenwood, T A, Tsuang, M T, Curtis, D, Steinberg, S, Sigurdsson, E, Stefánsson, H, Stefánsson, K, Edenberg, H J, Holmans, P, Faraone, S V & Glatt, S J 2021, ' A polygenic resilience score moderates the genetic risk for schizophrenia ', Molecular Psychiatry, vol. 26, no. 3, pp. 800–815 . https://doi.org/10.1038/s41380-019-0463-8
Molecular psychiatry, vol 26, iss 3
Hess, J L, Tylee, D S, Mattheisen, M, The Schizophrenia Working Group of the Psychiatric Genomics Consortium, Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Børglum, A D, Als, T D, Grove, J, Werge, T, Mortensen, P B, Mors, O, Nordentoft, M, Hougaard, D M, Byberg-grauholm, J, Bækvad-hansen, M, Greenwood, T A, Tsuang, M T, Curtis, D, Steinberg, S, Sigurdsson, E, Stefánsson, H, Stefánsson, K, Edenberg, H J, Holmans, P, Faraone, S V & Glatt, S J 2021, ' A polygenic resilience score moderates the genetic risk for schizophrenia ', Molecular Psychiatry, vol. 26, pp. 800–815 . https://doi.org/10.1038/s41380-019-0463-8
Molecular Psychiatry, 26(3), 800-815. Nature Publishing Group
Schizophrenia Working Group of the Psychiatric Genomics Consortium 2019, ' A polygenic resilience score moderates the genetic risk for schizophrenia ', Molecular Psychiatry . https://doi.org/10.1038/s41380-019-0463-8
Molecular psychiatry 26, 800–815 (2021). doi:10.1038/s41380-019-0463-8
Molecular psychiatry
Molecular psychiatry, 26, 800-815. Nature Publishing Group
Hess, J L, Tylee, D S, Mattheisen, M, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Børglum, A D, Als, T D, Grove, J, Werge, T, Mortensen, P B, Mors, O, Nordentoft, M, Hougaard, D M, Byberg-Grauholm, J, Bækvad-Hansen, M, Greenwood, T A, Tsuang, M T, Curtis, D, Steinberg, S, Sigurdsson, E, Stefánsson, H, Stefánsson, K, Edenberg, H J, Holmans, P, Faraone, S V & Glatt, S J 2021, ' A polygenic resilience score moderates the genetic risk for schizophrenia ', Molecular Psychiatry, vol. 26, no. 3, pp. 800–815 . https://doi.org/10.1038/s41380-019-0463-8
Molecular psychiatry, vol 26, iss 3
Hess, J L, Tylee, D S, Mattheisen, M, The Schizophrenia Working Group of the Psychiatric Genomics Consortium, Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Børglum, A D, Als, T D, Grove, J, Werge, T, Mortensen, P B, Mors, O, Nordentoft, M, Hougaard, D M, Byberg-grauholm, J, Bækvad-hansen, M, Greenwood, T A, Tsuang, M T, Curtis, D, Steinberg, S, Sigurdsson, E, Stefánsson, H, Stefánsson, K, Edenberg, H J, Holmans, P, Faraone, S V & Glatt, S J 2021, ' A polygenic resilience score moderates the genetic risk for schizophrenia ', Molecular Psychiatry, vol. 26, pp. 800–815 . https://doi.org/10.1038/s41380-019-0463-8
Molecular Psychiatry, 26(3), 800-815. Nature Publishing Group
Publisher's version (útgefin grein)
Based on the discovery by the Resilience Project (Chen R. et al. Nat Biotechnol 34:531–538, 2016) of rare variants that confer resistance to Mendelian disease, and protective alleles for some complex diseas
Based on the discovery by the Resilience Project (Chen R. et al. Nat Biotechnol 34:531–538, 2016) of rare variants that confer resistance to Mendelian disease, and protective alleles for some complex diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3471197df8fec836d8bcf93e6e4b37fd
https://research.vu.nl/en/publications/15dcf4e5-af27-45fe-b775-143bf7e22e6b
https://research.vu.nl/en/publications/15dcf4e5-af27-45fe-b775-143bf7e22e6b
Autor:
Okbay, Aysu, Wu, Yeda, Wang, Nancy, Jayashankar, Hariharan, Bennett, Michael, Nehzati, Seyed Moeen, Sidorenko, Julia, Kweon, Hyeokmoon, Goldman, Grant, Gjorgjieva, Tamara, Jiang, Yunxuan, Hicks, Barry, Tian, Chao, Hinds, David A., Ahlskog, Rafael, Magnusson, Patrik K. E., Oskarsson, Sven, Hayward, Caroline, Campbell, Archie, Porteous, David J., Freese, Jeremy, Herd, Pamela, Agee, Michelle, Alipanahi, Babak, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Furlotte, Nicholas A., Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McCreight, Jennifer C., McIntyre, Matthew H., Mountain, Joanna L., Northover, Carrie A. M., Pitts, Steven J., Sathirapongsasuti, J. Fah, Sazonova, Olga V., Shelton, Janie F., Shringarpure, Suyash, Tung, Joyce Y., Vacic, Vladimir, Wilson, Catherine H., Fontana, Mark Alan, Pers, Tune H., Rietveld, Cornelius A., Chen, Guo-Bo, Emilsson, Valur, Meddens, S. Fleur W., Pickrell, Joseph K., Thom, Kevin, Timshel, Pascal, de Vlaming, Ronald, Abdellaoui, Abdel, Ahluwalia, Tarunveer S., Bacelis, Jonas, Baumbach, Clemens, Bjornsdottir, Gyda, Brandsma, Johannes H., Concas, Maria Pina, Derringer, Jaime, Galesloot, Tessel E., Girotto, Giorgia, Gupta, Richa, Hall, Leanne M., Harris, Sarah E., Hofer, Edith, Horikoshi, Momoko, Huffman, Jennifer E., Kaasik, Kadri, Kalafati, Ioanna P., Karlsson, Robert, Lahti, Jari, van der Lee, Sven J., de Leeuw, Christiaan, Lind, Penelope A., Lindgren, Karl-Oskar, Liu, Tian, Mangino, Massimo, Marten, Jonathan, Mihailov, Evelin, Miller, Michael B., van der Most, Peter J., Oldmeadow, Christopher, Payton, Antony, Pervjakova, Natalia, Peyrot, Wouter J., Qian, Yong, Raitakari, Olli, Rueedi, Rico, Salvi, Erika, Schmidt, Börge, Schraut, Katharina E., Shi, Jianxin, Smith, Albert V., Poot, Raymond A., Pourcain, Beate St, Teumer, Alexander, Thorleifsson, Gudmar, Verweij, Niek, Vuckovic, Dragana, Wellmann, Juergen, Westra, Harm-Jan, Yang, Jingyun, Zhao, Wei, Zhu, Zhihong, Alizadeh, Behrooz Z., Amin, Najaf, Bakshi, Andrew, Baumeister, Sebastian E., Biino, Ginevra, Bønnelykke, Klaus, Boyle, Patricia A., Campbell, Harry, Cappuccio, Francesco P., Davies, Gail, De Neve, Jan-Emmanuel, Deloukas, Panos, Demuth, Ilja, Ding, Jun, Eibich, Peter, Eisele, Lewin, Eklund, Niina, Evans, David M., Faul, Jessica D., Feitosa, Mary F., Forstner, Andreas J., Gandin, Ilaria, Gunnarsson, Bjarni, Halldórsson, Bjarni V., Harris, Tamara B., Heath, Andrew C., Hocking, Lynne J., Holliday, Elizabeth G., Homuth, Georg, Horan, Michael A., Hottenga, Jouke-Jan, de Jager, Philip L., Joshi, Peter K., Jugessur, Astanand, Kaakinen, Marika A., Kähönen, Mika, Kanoni, Stavroula, Keltigangas-Järvinen, Liisa, Kiemeney, Lambertus A. L. M., Kolcic, Ivana, Koskinen, Seppo, Kraja, Aldi T., Kroh, Martin, Kutalik, Zoltan, Latvala, Antti, Launer, Lenore J., Lebreton, Maël P., Levinson, Douglas F., Lichtenstein, Paul, Lichtner, Peter, Liewald, David C. M., Loukola, Anu, Madden, Pamela A., Mägi, Reedik, Mäki-Opas, Tomi, Marioni, Riccardo E., Marques-Vidal, Pedro, Meddens, Gerardus A., McMahon, George, Meisinger, Christa, Meitinger, Thomas, Milaneschi, Yusplitri, Milani, Lili, Montgomery, Grant W., Myhre, Ronny, Nelson, Christopher P., Nyholt, Dale R., Ollier, William E. R., Palotie, Aarno, Paternoster, Lavinia, Pedersen, Nancy L., Petrovic, Katja E., Räikkönen, Katri, Ring, Susan M., Robino, Antonietta, Rostapshova, Olga, Rudan, Igor, Rustichini, Aldo, Salomaa, Veikko, Sanders, Alan R., Sarin, Antti-Pekka, Schmidt, Helena, Scott, Rodney J., Smith, Blair H., Smith, Jennifer A., Staessen, Jan A., Steinhagen-Thiessen, Elisabeth, Strauch, Konstantin, Terracciano, Antonio, Tobin, Martin D., Ulivi, Sheila, Vaccargiu, Simona, Quaye, Lydia, van Rooij, Frank J. A., Venturini, Cristina, Vinkhuyzen, Anna A. E., Völker, Uwe, Völzke, Henry, Vonk, Judith M., Vozzi, Diego, Waage, Johannes, Ware, Erin B., Willemsen, Gonneke, Attia, John R., Bennett, David A., Berger, Klaus, Bertram, Lars, Bisgaard, Hans, Boomsma, Dorret I., Borecki, Ingrid B., Bültmann, Ute, Chabris, Christopher F., Cucca, Francesco, Cusi, Daniele, Deary, Ian J., Dedoussis, George V., van Duijn, Cornelia M., Eriksson, Johan G., Franke, Barbara, Franke, Lude, Gasparini, Paolo, Gejman, Pablo V., Gieger, Christian, Grabe, Hans-Jörgen, Gratten, Jacob, Groenen, Patrick J. F., Gudnason, Vilmundur, van der Harst, Pim, Hoffmann, Wolfgang, Hyppönen, Elina, Iacono, William G., Jacobsson, Bo, Järvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Kaprio, Jaakko, Kardia, Sharon L. R., Lehtimäki, Terho, Lehrer, Steven F., Martin, Nicholas G., McGue, Matt, Metspalu, Andres, Pendleton, Neil, Penninx, Brenda W. J. H., Perola, Markus, Pirastu, Nicola, Pirastu, Mario, Polasek, Ozren, Posthuma, Danielle, Power, Christine, Province, Michael A., Samani, Nilesh J., Schlessinger, David, Schmidt, Reinhold, Sørensen, Thorkild I. A., Spector, Tim D., Stefansson, Kari, Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Tiemeier, Henning, Uitterlinden, André G., Vitart, Veronique, Vollenweider, Peter, Weir, David R., Wilson, James F., Wright, Alan F., Conley, Dalton C., Krueger, Robert F., Smith, George Davey, Hofman, Albert, Laibson, David I., Medland, Sarah E., Yang, Jian, Esko, Tõnu, Watson, Chelsea, Jala, Jonathan, Conley, Dalton, Koellinger, Philipp D., Johannesson, Magnus, Laibson, David, Meyer, Michelle N., Lee, James J., Kong, Augustine, Yengo, Loic, Cesarini, David, Turley, Patrick, Visscher, Peter M., Beauchamp, Jonathan P., Benjamin, Daniel J., Young, Alexander I.
Publikováno v:
2022, ' Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals ', Nature Genetics, vol. 54, no. 4, pp. 437-449 . https://doi.org/10.1038/s41588-022-01016-z
Okbay, A, Wu, Y, Wang, N, Jayashankar, H, Bennett, M, Nehzati, S M, Sidorenko, J, Kweon, H, Goldman, G, Gjorgjieva, T, Jiang, Y, Hicks, B, Tian, C, Hinds, D A, Ahlskog, R, Magnusson, P K E, Oskarsson, S, Hayward, C, Campbell, A, Porteous, D J, Freese, J, Herd, P, Agee, M, Alipanahi, B, Auton, A, Bell, R K, Bryc, K, Elson, S L, Fontanillas, P, Furlotte, N A, Hinds, D A, Huber, K E, Kleinman, A, Litterman, N K, McCreight, J C, McIntyre, M H, Mountain, J L, Northover, C A M, Pitts, S J, Sathirapongsasuti, J F, Sazonova, O V, Shelton, J F, Pers, T H, Timshel, P, Ahluwalia, T S, Bønnelykke, K, Bisgaard, H, Sørensen, T I A, 23andMe Research Team, Social Science Genetic Association Consortium & LifeLines Cohort Study 2022, ' Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals ', Nature Genetics, vol. 54, no. 4, pp. 437-449 . https://doi.org/10.1038/s41588-022-01016-z
Nature genetics, 54(4), 437-449. Nature Publishing Group
Nature Genetics
23Andme Research Team & Social Science Genetic Association Consortium 2022, ' Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals ', Nature genetics, vol. 54, no. 4, pp. 437-449 . https://doi.org/10.1038/s41588-022-01016-z
Nature Genetics, 54, 437-449
Nature Genetics, 54(4), 437-449. Nature Publishing Group
23andMe Research team, Social Science Genetic Association Consortium & Lifelines Cohort Study 2022, ' Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals ', Nature Genetics, vol. 54, no. 4, pp. 437-449 . https://doi.org/10.1038/s41588-022-01016-z
Okbay, A, Wu, Y, Wang, N, Jayashankar, H, Bennett, M, Nehzati, S M, Sidorenko, J, Kweon, H, Goldman, G, Gjorgjieva, T, Jiang, Y, Hicks, B, Tian, C, Hinds, D A, Ahlskog, R, Magnusson, P K E, Oskarsson, S, Hayward, C, Campbell, A, Porteous, D J, Freese, J, Herd, P, Agee, M, Alipanahi, B, Auton, A, Bell, R K, Bryc, K, Elson, S L, Fontanillas, P, Furlotte, N A, Hinds, D A, Huber, K E, Kleinman, A, Litterman, N K, McCreight, J C, McIntyre, M H, Mountain, J L, Northover, C A M, Pitts, S J, Sathirapongsasuti, J F, Sazonova, O V, Shelton, J F, Pers, T H, Timshel, P, Ahluwalia, T S, Bønnelykke, K, Bisgaard, H, Sørensen, T I A, 23andMe Research Team, Social Science Genetic Association Consortium & LifeLines Cohort Study 2022, ' Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals ', Nature Genetics, vol. 54, no. 4, pp. 437-449 . https://doi.org/10.1038/s41588-022-01016-z
Nature genetics, 54(4), 437-449. Nature Publishing Group
Nature Genetics
23Andme Research Team & Social Science Genetic Association Consortium 2022, ' Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals ', Nature genetics, vol. 54, no. 4, pp. 437-449 . https://doi.org/10.1038/s41588-022-01016-z
Nature Genetics, 54, 437-449
Nature Genetics, 54(4), 437-449. Nature Publishing Group
23andMe Research team, Social Science Genetic Association Consortium & Lifelines Cohort Study 2022, ' Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals ', Nature Genetics, vol. 54, no. 4, pp. 437-449 . https://doi.org/10.1038/s41588-022-01016-z
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of similar to 3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f0bbe92c3b9b0da9a12e7d0248be6c
https://www.pure.ed.ac.uk/ws/files/305359194/s41588_022_01016_z.pdf
https://www.pure.ed.ac.uk/ws/files/305359194/s41588_022_01016_z.pdf
Autor:
Saunders, Gretchen R. B., Wang, Xingyan, Chen, Fang, Jang, Seon-Kyeong, Liu, Mengzhen, Wang, Chen, Gao, Shuang, Jiang, Yu, Khunsriraksakul, Chachrit, Otto, Jacqueline M., Addison, Clifton, Akiyama, Masato, Albert, Christine M., Aliev, Fazil, Alonso, Alvaro, Arnett, Donna K., Ashley-Koch, Allison E., Ashrani, Aneel A., Barnes, Kathleen C., Barr, R. Graham, Bartz, Traci M., Becker, Diane M., Bielak, Lawrence F., Benjamin, Emelia J., Bis, Joshua C., Bjornsdottir, Gyda, Blangero, John, Bleecker, Eugene R., Boardman, Jason D., Boerwinkle, Eric, Boomsma, Dorret, Boorgula, Meher Preethi, Bowden, Donald W., Brody, Jennifer A., Cade, Brian E., Chasman, Daniel, Chavan, Sameer, Chen, Yii-Der Ida, Chen, Zhengming, Cheng, Iona, Cho, Michael H., Choquet, Helene, Cole, John W., Cornelis, Marilyn C., Cucca, Francesco, Curran, Joanne E., de Andrade, Mariza, Dick, Danielle M., Docherty, Anna R., Duggirala, Ravindranath, Eaton, Charles B., Ehringer, Marissa A., Esko, Tonu, Faul, Jessica D., Silva, Lilian Fernandes, Fiorillo, Edoardo, Fornage, Myriam, Freedman, Barry, Gabrielsen, Maiken E., Garrett, Melanie E., Gharib, Sina A., Gieger, Christian, Gillespie, Nathan, Glahn, David C., Gordon, Scott D., Gu, Charles C., Gu, Dongfeng, Gudbjartsson, Daniel F., Guo, Xiuqing, Haessler, Jeffrey, Hall, Michael E., Haller, Toomas, Harris, Kathleen Mullan, He, Jiang, Herd, Pamela, Hewitt, John K., Hickie, Ian, Hidalgo, Bertha, Hokanson, John E., Hopfer, Christian, Hottenga, JoukeJan, Hou, Lifang, Huang, Hongyan, Hung, Yi-Jen, Hunter, David J., Hveem, Kristian, Hwang, Shih-Jen, Hwu, Chii-Min, Iacono, William, Irvin, Marguerite R., Jee, Yon Ho, Johnson, Eric O., Joo, Yoonjung Y., Jorgenson, Eric, Justice, Anne E., Kamatani, Yoichiro, Kaplan, Robert C., Kaprio, Jaakko, Kardia, Sharon L. R., Keller, Matthew C., Kelly, Tanika N., Kooperberg, Charles, Korhonen, Tellervo, Kraft, Peter, Krauter, Kenneth, Kuusisto, Johanna, Laakso, Markku, Lasky-Su, Jessica, Lee, Wen-Jane, Lee, James J., Levy, Daniel, Li, Liming, Li, Kevin, Li, Yuqing, Lin, Kuang, Lind, Penelope A., Liu, Chunyu, Lloyd-Jones, Donald M., Lutz, Sharon M., Ma, Jiantao, Magi, Reedik, Manichaikul, Ani, Martin, Nicholas G., Mathur, Ravi, Matoba, Nana, McArdle, Patrick F., McGue, Matt, McQueen, Matthew B., Medland, Sarah E., Metspalu, Andres, Meyers, Deborah A., Millwood, Iona Y., Mitchell, Braxton D., Mohlke, Karen L., Moll, Matthew, Montasser, May E., Morrison, Alanna C., Mulas, Antonella, Nielsen, Jonas B., North, Kari E., Oelsner, Elizabeth C., Okada, Yukinori, Orru, Valeria, Palmer, Nicholette D., Palviainen, Teemu, Pandit, Anita, Park, S. Lani, Peters, Ulrike, Peters, Annette, Peyser, Patricia A., Polderman, Tinca J. C., Rafaels, Nicholas, Redline, Susan, Reed, Robert M., Reiner, Alex P., Rice, John P., Rich, Stephen S., Richmond, Nicole E., Roan, Carol, Rotter, Jerome, Rueschman, Michael N., Runarsdottir, Valgerdur, Saccone, Nancy L., Schwartz, David A., Shadyab, Aladdin H., Shi, Jingchunzi, Shringarpure, Suyash S., Sicinski, Kamil, Skogholt, Anne Heidi, Smith, Jennifer A., Smith, Nicholas L., Sotoodehnia, Nona, Stallings, Michael C., Stefansson, Hreinn, Stefansson, Kari, Stitzel, Jerry A., Sun, Xiao, Syed, Moin, Tal-Singer, Ruth, Taylor, Amy E., Taylor, Kent D., Telen, Marilyn J., Thai, Khanh K., Tiwari, Hemant, Turman, Constance, Tyrfingsson, Thorarinn, Wall, Tamara L., Walters, Robin G., Weir, David R., Weiss, Scott T., White, Wendy B., Whitfield, John B., Wiggins, Kerri L., Willemsen, Gonneke, Willer, Cristen J., Winsvold, Bendik S., Xu, Huichun, Yanek, Lisa R., Yin, Jie, Young, Kristin L., Young, Kendra A., Yu, Bing, Zhao, Wei, Zhou, Wei, Zollner, Sebastian, Zuccolo, Luisa, Project, The Biobank Japan, Batini, Chiara, Bergen, Andrew W., Bierut, Laura J., David, Sean P., Taliun, Sarah A. Gagliano, Hancock, Dana B., Jiang, Bibo, Munafo, Marcus R., Thorgeirsson, Thorgeir E., Liu, Dajiang J., Vrieze, Scott
Publikováno v:
23andMe Research team & The Biobank Japan Project 2022, ' Genetic diversity fuels gene discovery for tobacco and alcohol use ', Nature, vol. 612, no. 7941, pp. 720-724 . https://doi.org/10.1038/s41586-022-05477-4
Nature, 612(7941), 720-724. Nature Publishing Group
Saunders, G R B, Wang, X, Chen, F, Boomsma, D I, Hottenga, J J, Polderman, T J C, Willemsen, G, Thorgeirsson, T E, Liu, D J, Vrieze, S, 23Andme Research Team & The Biobank Japan Project 2022, ' Genetic diversity fuels gene discovery for tobacco and alcohol use ', Nature, vol. 612, no. 7941, pp. 720-724 . https://doi.org/10.1038/s41586-022-05477-4
the 23 and Me Research Team 2022, ' Genetic diversity fuels gene discovery for tobacco and alcohol use ', Nature, vol. 612, no. 7941, pp. 720-724 . https://doi.org/10.1038/s41586-022-05477-4
Nature 612, 720–724 (2022)
Nature, 612(7941), 720-724. Nature Publishing Group
Saunders, G R B, Wang, X, Chen, F, Boomsma, D I, Hottenga, J J, Polderman, T J C, Willemsen, G, Thorgeirsson, T E, Liu, D J, Vrieze, S, 23Andme Research Team & The Biobank Japan Project 2022, ' Genetic diversity fuels gene discovery for tobacco and alcohol use ', Nature, vol. 612, no. 7941, pp. 720-724 . https://doi.org/10.1038/s41586-022-05477-4
the 23 and Me Research Team 2022, ' Genetic diversity fuels gene discovery for tobacco and alcohol use ', Nature, vol. 612, no. 7941, pp. 720-724 . https://doi.org/10.1038/s41586-022-05477-4
Nature 612, 720–724 (2022)
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury1–4. These substances are used across the globe, yet genome-wide association
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https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dab5dadb7bb73de329904d5d856c385
https://pubmed.ncbi.nlm.nih.gov/36477530
https://pubmed.ncbi.nlm.nih.gov/36477530
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Autor:
Howe, Laurence J., Nivard, Michel G., Morris, Tim T., Hansen, Ailin F., Rasheed, Humaira, Cho, Yoonsu, Chittoor, Geetha, Ahlskog, Rafael, Lind, Penelope A., Palviainen, Teemu, van der Zee, Matthijs D., Cheesman, Rosa, Mangino, Massimo, Wang, Yunzhang, Li, Shuai, Klaric, Lucija, Ratliff, Scott M., Bielak, Lawrence F., Nygaard, Marianne, Giannelis, Alexandros, Willoughby, Emily A., Reynolds, Chandra A., Balbona, Jared V., Andreassen, Ole A., Ask, Helga, Baras, Aris, Bauer, Christopher R., Boomsma, Dorret I., Campbell, Archie, Campbell, Harry, Chen, Zhengming, Christofidou, Paraskevi, Corfield, Elizabeth, Dahm, Christina C., Dokuru, Deepika R., Evans, Luke M., de Geus, Eco J. C., Giddaluru, Sudheer, Gordon, Scott D., Harden, K. Paige, Hill, W. David, Hughes, Amanda, Kerr, Shona M., Kim, Yongkang, Kweon, Hyeokmoon, Latvala, Antti, Lawlor, Deborah A., Li, Liming, Lin, Kuang, Magnus, Per, Magnusson, Patrik K. E., Mallard, Travis T., Martikainen, Pekka, Mills, Melinda C., Njølstad, Pål Rasmus, Overton, John D., Pedersen, Nancy L., Porteous, David J., Reid, Jeffrey, Silventoinen, Karri, Southey, Melissa C., Stoltenberg, Camilla, Tucker-Drob, Elliot M., Wright, Margaret J., Koellinger, Philipp D., Benjamin, Daniel J., Turley, Patrick, Hewitt, John K., Keller, Matthew C., Stallings, Michael C., Lee, James J., Christensen, Kaare, Kardia, Sharon L. R., Peyser, Patricia A., Smith, Jennifer A., Wilson, James F., Hopper, John L., Hägg, Sara, Spector, Tim D., Pingault, Jean-Baptiste, Plomin, Robert, Havdahl, Alexandra, Bartels, Meike, Martin, Nicholas G., Oskarsson, Sven, Justice, Anne E., Millwood, Iona Y., Hveem, Kristian, Naess, Øyvind, Willer, Cristen J., Åsvold, Bjørn Olav, Kaprio, Jaakko, Medland, Sarah E., Walters, Robin G., Evans, David M., Smith, George Davey, Hayward, Caroline, Brumpton, Ben, Hemani, Gibran, Davies, Neil M., Davey Smith, George
Publikováno v:
Nature genetics, vol 54, iss 5
Nature Genetics
Nature genetics, 54(5), 581-592. Nature Publishing Group
2022, ' Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects ', Nature Genetics, vol. 54, no. 5, pp. 581-592 . https://doi.org/10.1038/s41588-022-01062-7
Howe, L J, Nivard, M G, Morris, T T, Hansen, A F, Rasheed, H, van der Zee, M D, Boomsma, D I, de Geus, E J C, Kweon, H, Koellinger, P D, Bartels, M, Davey Smith, G, Hayward, C, Brumpton, B, Hemani, G, Davies, N M & Social Science Genetic Association Consortium 2022, ' Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects ', Nature genetics, vol. 54, no. 5, pp. 581-592 . https://doi.org/10.1038/s41588-022-01062-7
Howe, L J, Nivard, M G, Morris, T T, Hansen, A F, Rasheed, H, Cho, Y, Chittoor, G, Ahlskog, R, Lind, P A, Palviainen, T, van der Zee, M D, Cheesman, R, Mangino, M, Wang, Y, Li, S, Klaric, L, Ratliff, S M, Bielak, L F, Nygaard, M, Giannelis, A, Willoughby, E A, Reynolds, C A, Balbona, J V, Andreassen, O A, Ask, H, Baras, A, Bauer, C R, Boomsma, D I, Campbell, A, Campbell, H, Chen, Z, Christofidou, P, Corfield, E, Dahm, C C, Dokuru, D R, Evans, L M, de Geus, E J C, Giddaluru, S, Gordon, S D, Harden, K P, Hill, W D, Hughes, A, Kerr, S M, Kim, Y, Kweon, H, Latvala, A, Lawlor, D A, Li, L, Lin, K, Christensen, K, Social Science Genetic Association Consortium & Within Family Consortium (Christina Dahm; member) 2022, ' Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects ', Nature Genetics, vol. 54, no. 5, pp. 581-592 . https://doi.org/10.1038/s41588-022-01062-7
Nature Genetics
Nature genetics, 54(5), 581-592. Nature Publishing Group
2022, ' Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects ', Nature Genetics, vol. 54, no. 5, pp. 581-592 . https://doi.org/10.1038/s41588-022-01062-7
Howe, L J, Nivard, M G, Morris, T T, Hansen, A F, Rasheed, H, van der Zee, M D, Boomsma, D I, de Geus, E J C, Kweon, H, Koellinger, P D, Bartels, M, Davey Smith, G, Hayward, C, Brumpton, B, Hemani, G, Davies, N M & Social Science Genetic Association Consortium 2022, ' Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects ', Nature genetics, vol. 54, no. 5, pp. 581-592 . https://doi.org/10.1038/s41588-022-01062-7
Howe, L J, Nivard, M G, Morris, T T, Hansen, A F, Rasheed, H, Cho, Y, Chittoor, G, Ahlskog, R, Lind, P A, Palviainen, T, van der Zee, M D, Cheesman, R, Mangino, M, Wang, Y, Li, S, Klaric, L, Ratliff, S M, Bielak, L F, Nygaard, M, Giannelis, A, Willoughby, E A, Reynolds, C A, Balbona, J V, Andreassen, O A, Ask, H, Baras, A, Bauer, C R, Boomsma, D I, Campbell, A, Campbell, H, Chen, Z, Christofidou, P, Corfield, E, Dahm, C C, Dokuru, D R, Evans, L M, de Geus, E J C, Giddaluru, S, Gordon, S D, Harden, K P, Hill, W D, Hughes, A, Kerr, S M, Kim, Y, Kweon, H, Latvala, A, Lawlor, D A, Li, L, Lin, K, Christensen, K, Social Science Genetic Association Consortium & Within Family Consortium (Christina Dahm; member) 2022, ' Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects ', Nature Genetics, vol. 54, no. 5, pp. 581-592 . https://doi.org/10.1038/s41588-022-01062-7
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79333b5ded2e2eaeb727a1345dda5ae
http://hdl.handle.net/10852/96631
http://hdl.handle.net/10852/96631