Zobrazeno 1 - 10
of 7 507
pro vyhledávání: '"Multicomponent reaction"'
Autor:
Jie Gao, Yonghua Zhai, Weihong Lu, Xianghe Jiang, Jingsheng Zhou, Lili Wu, Longhai Du, Chunqing Ou, Xinyi Zhang, Hanliang He, Jian Zhu, Zhengbiao Zhang, Meiyun Li, Yan Wu, Xiangqiang Pan
Publikováno v:
Bioactive Materials, Vol 41, Iss , Pp 597-610 (2024)
In the field of cancer therapy, inhibiting autophagy has emerged as a promising strategy. However, pharmacological disruption of autophagy can lead to the upregulation of programmed death-ligand 1 (PD-L1), enabling tumor immune evasion. To address th
Externí odkaz:
https://doaj.org/article/0132123d6b9148a8a2f00a01aa7fa5b6
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 2024-2077 (2024)
Pyrazoles are rarely found in nature but are traditionally used in the agrochemical and pharmaceutical industries, while other areas of use are also actively developing. However, they have also found numerous other applications. The search for new an
Externí odkaz:
https://doaj.org/article/c4c8dfdcb1e64ce09a7f54cae8329d37
Autor:
Kateryna V. Dil, Vitalii A. Palchykov
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 2143-2151 (2024)
A one-pot three-component Biginelli synthesis of dihydropyrimidinones/thiones/selenones via acetic acid or solvent-free Yb(OTf)3-catalyzed tandem reaction of β-ketosulfone (dihydro-2H-thiopyran-3(4H)-one-1,1-dioxide), an appropriate urea, and arylal
Externí odkaz:
https://doaj.org/article/8bba997055ed4d9e9dc7bb4818b34758
Autor:
Alexander V. Tsygankov, Vladyslav O. Vereshchak, Tetiana O. Savluk, Serhiy M. Desenko, Valeriia V. Ananieva, Oleksandr V. Buravov, Yana I. Sakhno, Svitlana V. Shishkina, Valentyn A. Chebanov
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1773-1784 (2024)
By one-pot four- and three-component Ugi reactions involving convertible isocyanides and unexplored pyrrole-containing β-chlorovinylaldehyde, a small library of 20 bisamides with unusual behavior in post-Ugi transformations was prepared and characte
Externí odkaz:
https://doaj.org/article/c87805b4505340978329371bae41d434
Autor:
Nuzhat Rehman, Ayaz Mahmood Dar, Raja Feroz Ahmad Haji, Sharief-ud-din Khan, Deepak Pareek, Saleem Farooq, Bashir Ahmad Dar
Publikováno v:
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, Vol 19, Iss 1, Pp 76-83 (2024)
This study introduces an environmentally sustainable approach for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs), via the Biginelli reaction. A heterogeneous catalyst, Heteropolyacid-Clay (HPA-Clay), is developed by immobilizing H5PV2W10O40
Externí odkaz:
https://doaj.org/article/bb7a639bfc2f4f6fa1bbec6a85d11f42
Autor:
Julio C. Flores-Reyes, Annia Galano, Sandra M. Rojas-Montoya, Luis Blancarte-Carrazco, Elba Xochitiotzi-Flores, Héctor García-Ortega, Norberto Farfán, Alejandro Islas-Jácome, Eduardo González-Zamora
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
A series of seven new meso-phenyl BODIPY-pyrrolo[3,4-b]pyridin-5-one conjugates were synthesized in one experimental step by using a Sc(III)-catalyzed Ugi-Zhu three-component reaction coupled to a cascade sequence (aza Diels-Alder/N-acylation/aromati
Externí odkaz:
https://doaj.org/article/c1637e0cde724991b378fa0e769f5517
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37151- (2024)
In this study, a green and environmentally friendly catalyst (MgZnFe2O4@ZSC-Cu) was synthesized using a simple and clean method. The catalyst was prepared by combining MgZnFe2O4 MNPs with Ziziphus spina-christi extract (ZSC) and immobilizing Cu ions
Externí odkaz:
https://doaj.org/article/3c2cb29cc0d0435fb9e1a5f295fc077d
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 950-958 (2024)
Tetrazole is widely utilized as a bioisostere for carboxylic acid in the field of medicinal chemistry and drug development, enhancing the drug-like characteristics of various molecules. Typically, tetrazoles are introduced from their nitrile precurso
Externí odkaz:
https://doaj.org/article/f69bf6c7f31f4a4c94fe093f600f7619
Publikováno v:
Advanced Science, Vol 11, Iss 25, Pp n/a-n/a (2024)
Abstract Here, a photocatalytic asymmetric multicomponent cascade Minisci reaction of β‐carbolines with enamides and diazo compounds is reported, enabling an effective enantioselective radical C─H functionalization of β‐carbolines with high y
Externí odkaz:
https://doaj.org/article/cfd639dccd07468fbfd091ef3b40b7af
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
A novel biocompatible composite was fabricated by the functionalization of magnetic chitosan with the melamine phosphate (MP) ionic compound to serve as a recoverable and bifunctional catalyst, aiming at the diversity-oriented generation of biologica
Externí odkaz:
https://doaj.org/article/2b85fa8ffc5f4708b3e7122ce900dea0