Zobrazeno 1 - 10
of 12 471
pro vyhledávání: '"Multicomponent Reactions"'
Publikováno v:
SynOpen, Vol 08, Iss 04, Pp 300-327 (2024)
Externí odkaz:
https://doaj.org/article/8e930b906da34ff2b95c97e3656f6037
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 2870-2882 (2024)
An efficient and facile synthesis of pyrrole-fused dibenzoxazepine/dibenzothiazepine/triazolobenzodiazepine derivatives was developed through the isocyanide-based multicomponent reaction of isocyanides, gem-diactivated olefins, and cyclic imines such
Externí odkaz:
https://doaj.org/article/31ab459933a44376bb32ec287fb8da2a
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 2722-2731 (2024)
Spiro-heterocyclic indolenines are privileged scaffolds widely present in numerous indole alkaloids. Here, we develop a novel approach for the one-pot multistep synthesis of different spiro[indole-isoquinolines]. The protocol proposed involves the vi
Externí odkaz:
https://doaj.org/article/62691eb74e854b35bd33c73c3ae434ae
Autor:
Kevin Schofield, Shayna Maddern, Yueteng Zhang, Grace E. Mastin, Rachel Knight, Wei Wang, James Galligan, Christopher Hulme
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 2270-2279 (2024)
The utility of bio-isosteres is broad in drug discovery and methodology herein enables the preparation of deuterium-labeled products is the most fundamental of known bio-isosteric replacements. As such we report the use of both [D1]-aldehydes and [D2
Externí odkaz:
https://doaj.org/article/faf573af030a4151bcf777a1b3ca1748
Publikováno v:
Organics, Vol 5, Iss 3, Pp 298-345 (2024)
Barbituric acid is a heterocyclic compound with various pharmacological and biological applications. This review paper provides a comprehensive overview of barbituric acid’s synthesis, reactions, and bio-applications, highlighting its multifaceted
Externí odkaz:
https://doaj.org/article/f1fe2c370dd94523a5f8aeb9858b9df1
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1839-1879 (2024)
The Groebke–Blackburn–Bienaymé (GBB) three-component reaction, discovered in 1998, is a very efficient strategy to assemble imidazo[1,2-a]-heterocycles starting from amidines, aldehydes and isocyanides. This review aims to exhaustively describe
Externí odkaz:
https://doaj.org/article/dc9a61c876f64a4f98db892e5c832bc0
Publikováno v:
Results in Chemistry, Vol 12, Iss , Pp 101848- (2024)
Natural deep eutectic solvents (NADESs) have emerged as a novel class of solvents with properties reminiscent of ionic liquids while offering additional advantages in terms of cost, environmental impact, and synthesis. This article focuses on the app
Externí odkaz:
https://doaj.org/article/ca6fa335003e42268845b866389f3de1
Publikováno v:
ChemistryOpen, Vol 13, Iss 11, Pp n/a-n/a (2024)
Abstract Heterocycles are a vital class of compounds in numerous fields, including drug discovery, agriculture, and materials science. Efficient methods for the synthesis of heterocycles remain critical for meeting the demands of these industries. Re
Externí odkaz:
https://doaj.org/article/46b119092f854e57b2218ef22eaad548
Autor:
Evgen V. Govor, Vasyl Naumchyk, Ihor Nestorak, Dmytro S. Radchenko, Dmytro Dudenko, Yurii S. Moroz, Olexiy D. Kachkovsky, Oleksandr O. Grygorenko
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1604-1613 (2024)
Parallel Groebke–Blackburn–Bienaymé reaction was evaluated as a source of multimillion chemically accessible chemical space. Two most popular classical protocols involving the use of Sc(OTf)3 and TsOH as the catalysts were tested on a broad subs
Externí odkaz:
https://doaj.org/article/8a00b5008bef496d9d9190f889df40bb
Challenge N- versus O-six-membered annulation: FeCl3-catalyzed synthesis of heterocyclic N,O-aminals
Autor:
Giacomo Mari, Lucia De Crescentini, Gianfranco Favi, Fabio Mantellini, Diego Olivieri, Stefania Santeusanio
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1412-1420 (2024)
A new class of heterocyclic N,O-aminal and hemiaminal scaffolds was successfully obtained by means of a three-component reaction (3-CR) of 1,2-diaza-1,3-dienes (DDs), α-aminoacetals and iso(thio)cyanates. These stable imine surrogates are generated
Externí odkaz:
https://doaj.org/article/cbb5226a12ef4b53ae28ed563372d1ee