Zobrazeno 1 - 10
of 1 191
pro vyhledávání: '"Multi-omics analysis"'
Autor:
Li Chen, Yuanbo Hu, Yu Li, Bingyu Zhang, Jiale Wang, Mengmeng Deng, Jinlian Zhang, Wenyao Zhu, Hao Gu, Lingyu Zhang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-23 (2024)
Abstract Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with increasing global prevalence and is one of the leading causes of cancer-related mortality in the human population. Developing robust clinical prediction models and prognos
Externí odkaz:
https://doaj.org/article/287e526dbafc40b58d73bc1d9744d491
Autor:
Guolong Zeng, Yifan Yu, Meiting Wang, Jiaxing Liu, Guangpeng He, Sixuan Yu, Huining Yan, Liang Yang, Hangyu Li, Xueqiang Peng
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract The complexity of tumors and the challenges associated with treatment often stem from the limitations of existing models in accurately replicating authentic tumors. Recently, organoid technology has emerged as an innovative platform for tumo
Externí odkaz:
https://doaj.org/article/49b3e81a56da44db99e39b8cc217b1cd
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-13 (2024)
Abstract Background Succinic acid (SA) is an important bio-based C4 platform chemical with versatile applications, including the production of 1,4-butanediol, tetrahydrofuran, and γ-butyrolactone. The non-conventional yeast Yarrowia lipolytica has g
Externí odkaz:
https://doaj.org/article/2badb7d3a3214cc1a2830282b466f192
Autor:
Fengyang Jing, Lijing Zhu, Jianyun Zhang, Xuan Zhou, Jiaying Bai, Xuefen Li, Heyu Zhang, Tiejun Li
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Background Lactylation, a post-translational modification, is increasingly recognized for its role in cancer progression. This study investigates its prevalence and impact in oral squamous cell carcinoma (OSCC). Results Immunohistochemical s
Externí odkaz:
https://doaj.org/article/e36136104637453f99f6e725abc29782
Autor:
Silvia Barbon, Fabrizio Armellin, Verena Passerini, Sergio De Angeli, Simona Primerano, Laura Del Pup, Elisabetta Durante, Veronica Macchi, Raffaele De Caro, Pier Paolo Parnigotto, Arianna Veronesi, Andrea Porzionato
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) represents the biggest global health emergency in recent decades. The host immune response to SARS-CoV-2 seems to play a key role in dise
Externí odkaz:
https://doaj.org/article/20aad837dc844546b30727688888e257
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Akebia trifoliata is a medicinal plant with high oil content and broad pharmacological effects. To investigate the regulatory mechanisms of key metabolic pathways during seed development, we conducted an integrated multi-omics analysis, incl
Externí odkaz:
https://doaj.org/article/865e401bbdbd4761a2bbf7144bec75d4
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract This study integrates pharmacology databases with bulk RNA-seq and scRNA-seq to reveal the latent anti-PDAC capacities of BBR. Target genes of BBR were sifted through TargetNet, CTD, SwissTargetPrediction, and Binding Database. Based on the
Externí odkaz:
https://doaj.org/article/5e4acf66e59b4f81b2a85550d17752e8
Publikováno v:
BMC Plant Biology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Camellia nitidissima is a rare, prized camellia species with golden-yellow flowers. It has a high ornamental, medicinal, and economic value. Previous studies have shown substantial flavonol accumulation in C. nitidissima petals du
Externí odkaz:
https://doaj.org/article/217ab23fed164e5892d5e7e83b02c5b4
Autor:
Ken Asada, Syuzo Kaneko, Ken Takasawa, Kouya Shiraishi, Norio Shinkai, Yoko Shimada, Satoshi Takahashi, Hidenori Machino, Kazuma Kobayashi, Amina Bolatkan, Masaaki Komatsu, Masayoshi Yamada, Mototaka Miyake, Hirokazu Watanabe, Akiko Tateishi, Takaaki Mizuno, Yu Okubo, Masami Mukai, Tatsuya Yoshida, Yukihiro Yoshida, Hidehito Horinouchi, Shun-Ichi Watanabe, Yuichiro Ohe, Yasushi Yatabe, Takashi Kohno, Ryuji Hamamoto
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-9 (2024)
Abstract Background The cancer genome contains several driver mutations. However, in some cases, no known drivers have been identified; these remaining areas of unmet needs, leading to limited progress in cancer therapy. Whole-genome sequencing (WGS)
Externí odkaz:
https://doaj.org/article/5ca317bc30aa4ff796701baac2c9a5a6
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1912-1918 (2024)
Translational regulation plays the most critical role in gene expression. Ribosome profiling sequencing (Ribo-Seq) is one of the methods to study translation and its regulation. It is a high throughput technology based on deep sequencing, which targe
Externí odkaz:
https://doaj.org/article/a48f8e969ab64f28ae7e647473b3c4fb