A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α-primase.

Autor: Mullins EA; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA., Salay LE; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Durie CL; Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI, USA.; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Biochemistry, University of Missouri, Columbia, MO, USA., Bradley NP; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA., Jackman JE; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.; Center for RNA Biology, The Ohio State University, Columbus, OH, USA., Ohi MD; Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI, USA.; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Chazin WJ; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA. walter.j.chazin@vanderbilt.edu.; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA. walter.j.chazin@vanderbilt.edu.; Department of Chemistry, Vanderbilt University, Nashville, TN, USA. walter.j.chazin@vanderbilt.edu., Eichman BF; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA. brandt.eichman@vanderbilt.edu.; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA. brandt.eichman@vanderbilt.edu.; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA. brandt.eichman@vanderbilt.edu.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2024 May; Vol. 31 (5), pp. 777-790. Date of Electronic Publication: 2024 Mar 15.

A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α-primase.

Autor: Mullins EA, Salay LE, Durie CL, Bradley NP, Jackman JE, Ohi MD, Chazin WJ, Eichman BF

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 28. Date of Electronic Publication: 2023 Sep 28.

Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites.

Autor: Mullins EA; Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA., Dorival J; Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA., Tang GL; State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China., Boger DL; Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA., Eichman BF; Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA. brandt.eichman@vanderbilt.edu.; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. brandt.eichman@vanderbilt.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Nov 26; Vol. 12 (1), pp. 6942. Date of Electronic Publication: 2021 Nov 26.

Selective base excision repair of DNA damage by the non-base-flipping DNA glycosylase AlkC.

Autor: Shi R; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA., Mullins EA; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA., Shen XX; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA., Lay KT; Department of Chemistry, University of California, Davis, CA, USA., Yuen PK; Department of Chemistry, University of California, Davis, CA, USA., David SS; Department of Chemistry, University of California, Davis, CA, USA., Rokas A; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA., Eichman BF; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA brandt.eichman@vanderbilt.edu.

Publikováno v: The EMBO journal [EMBO J] 2018 Jan 04; Vol. 37 (1), pp. 63-74. Date of Electronic Publication: 2017 Oct 20.

Structure of a DNA glycosylase that unhooks interstrand cross-links.

Autor: Mullins EA; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232.; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232., Warren GM; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232.; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232., Bradley NP; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232.; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232., Eichman BF; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232; brandt.eichman@vanderbilt.edu.; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232.; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Apr 25; Vol. 114 (17), pp. 4400-4405. Date of Electronic Publication: 2017 Apr 10.