Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Mulin Jun Li"'
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110064- (2024)
Summary: Glioblastoma multiforme (GBM) is one of the most lethal brain tumors, characterized by profound heterogeneity. While single-cell transcriptomic studies have revealed extensive intra-tumor heterogeneity, shed light on intra-tumor diversity, s
Externí odkaz:
https://doaj.org/article/486eceb996b64f7c8896197b8e820398
Autor:
Ying Chang, Yao Zhou, Junrui Zhou, Wen Li, Jiasong Cao, Yaqing Jing, Shan Zhang, Yongmei Shen, Qimei Lin, Xutong Fan, Hongxi Yang, Xiaobao Dong, Shijie Zhang, Xianfu Yi, Ling Shuai, Lei Shi, Zhe Liu, Jie Yang, Xin Ma, Jihui Hao, Kexin Chen, Mulin Jun Li, Feng Wang, Dandan Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Telomere length (TL) shortening is a pivotal indicator of biological aging and is associated with many human diseases. The genetic determinates of human TL have been widely investigated, however, most existing studies were conducted based on
Externí odkaz:
https://doaj.org/article/cc2719ec56f94fb89af73e6da3a3b4ad
Autor:
Haixu Xu, Xianfu Yi, Zhaohai Cui, Hui Li, Lin Zhu, Lijuan Zhang, JiaLe Chen, Xutong Fan, Pan Zhou, Mulin Jun Li, Ying Yu, Qiang Liu, Dandan Huang, Zhi Yao, Jie Zhou
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Microbiota have an important function in shaping and priming neonatal immunity, although the cellular and molecular mechanisms underlying these effects remain obscure. Here we report that prenatal antibiotic exposure causes significant eleva
Externí odkaz:
https://doaj.org/article/5f372ea0c1694dd69f440194ede2aba2
Autor:
Zhichao Liao, Jianjin Teng, Tao Li, Haotian Liu, Ting Li, Chao Zhang, Ruwei Xing, Sheng Teng, Yun Yang, Jun Zhao, Wanyi Xiao, Gengpu Zhang, Mulin Jun Li, Weitao Yao, Jilong Yang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundSarcoma is a highly heterogeneous malignancy with a poor prognosis. Although chemotherapy and targeted therapy have improved the prognosis to some extent, the efficacy remains unsatisfactory in some patients. The efficacy and safety of immu
Externí odkaz:
https://doaj.org/article/9a44e26d31ed4aea83d878e10b23e41a
Autor:
Zhao Wang, Menghan Luo, Qian Liang, Ke Zhao, Yuelin Hu, Wei Wang, Xiangling Feng, Bolang Hu, Jianjin Teng, Tianyi You, Ran Li, Zhengkai Bao, Wenhao Pan, Tielong Yang, Chao Zhang, Ting Li, Xiaobao Dong, Xianfu Yi, Ben Liu, Li Zhao, Miaoxin Li, Kexin Chen, Weihong Song, Jilong Yang, Mulin Jun Li
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-32 (2023)
Abstract Background The high mutation rate throughout the entire melanoma genome presents a major challenge in stratifying true driver events from the background mutations. Numerous recurrent non-coding alterations, such as those in enhancers, can sh
Externí odkaz:
https://doaj.org/article/ea2c5d7f313e4e34877e64882a16ffd9
Autor:
Liubin Zhang, Yangyang Yuan, Wenjie Peng, Bin Tang, Mulin Jun Li, Hongsheng Gui, Qiang Wang, Miaoxin Li
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract Whole -genome sequencing projects of millions of subjects contain enormous genotypes, entailing a huge memory burden and time for computation. Here, we present GBC, a toolkit for rapidly compressing large-scale genotypes into highly addressa
Externí odkaz:
https://doaj.org/article/d4f6f3be3aab4bcba4e0de1f78462441
Autor:
Chao Wang, Jingjing Zhou, Lili Wang, Tongyu Xing, Hongji Dai, Yao Zhou, Lisha Qi, Yanrui Zhao, Caiyun Huang, Ding Li, Haixin Li, Mulin Jun Li, Ben Liu, Hong Zheng, Kexin Chen, Lian Li
Publikováno v:
Cancer Medicine, Vol 12, Iss 6, Pp 7498-7507 (2023)
Abstract Background ABO blood groups has been associated with risk of several cancers; however, the results for an association with ovarian cancer are inconsistent and little is known about the expression of histo‐blood group (ABH) antigens and ABO
Externí odkaz:
https://doaj.org/article/251ee45bcf61477981e92457ad5178bb
Autor:
Zhao Wang, Qian Liang, Xinyi Qian, Bolang Hu, Zhanye Zheng, Jianhua Wang, Yuelin Hu, Zhengkai Bao, Ke Zhao, Yao Zhou, Xiangling Feng, Xianfu Yi, Jin Li, Jiandang Shi, Zhe Liu, Jihui Hao, Kexin Chen, Ying Yu, Pak Chung Sham, Wange Lu, Xiaoyan Wang, Weihong Song, Mulin Jun Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Here the authors used an evidence-based strategy to prioritize causal pleiotropic variants of autoimmune diseases, and revealed that rs4728142 modulates aberrant IRF5 alternative promoter usage by ZBTB3-mediated chromatin looping.
Externí odkaz:
https://doaj.org/article/5ffe2bc8274f43c38d73f0ef593fd3ec
Autor:
Yuyang Qian, Jianhua Wang, Bo Wang, Wenbin Wang, Peng Li, Zhenhao Zhao, Yuan Jiang, He Ren, Dandan Huang, Yang Yang, Zhongfang Zhao, Lei Zhang, Jiandang Shi, Mulin Jun Li, Wange Lu
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106497- (2023)
Summary: To date, genome-wide association studies (GWAS) have revealed over 200 genetic risk loci associated with prostate cancer; yet, true disease-causing variants remain elusive. Identification of causal variants and their targets from association
Externí odkaz:
https://doaj.org/article/bec4d6fa7aef4208bca3f857105ce0bd
Autor:
Weishuai Liu, Xiaozhou Yu, Yudong Yuan, Yixing Feng, Chao Wu, Chongbiao Huang, Peng Xie, Shengnan Li, Xiaofeng Li, Ziyang Wang, Lisha Qi, Yanan Chen, Lei Shi, Mulin Jun Li, Zhiyong Huang, Bo Tang, Antao Chang, Jihui Hao
Publikováno v:
Advanced Science, Vol 10, Iss 6, Pp n/a-n/a (2023)
Abstract CD73, a cell surface‐bound nucleotidase, facilitates extracellular adenosine formation by hydrolyzing 5′‐AMP to adenosine. Several studies have shown that CD73 plays an essential role in immune escape, cell proliferation and tumor angi
Externí odkaz:
https://doaj.org/article/23758192030f42d88d19737b38c990d1