Reversal of P-glycoprotein-mediated multidrug resistance by natural N-alkylated indole alkaloid derivatives in KB-ChR-8-5 drug-resistant cancer cells.

Autor: Bharathiraja P; Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Tamil Nadu, India., Cardoso DSP; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal., Rajendra Prasad N; Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Tamil Nadu, India., Mulhovo S; Centro de Estudos Moçambicanos e de Etnociências (CEMEC), Faculdade de Ciências Naturais e Matemática, Universidade Pedagógica Campus de Lhanguene, Maputo, Moçambique., Lakra DS; Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Tamil Nadu, India., Ferreira MU; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.

Publikováno v: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2023 Sep; Vol. 37 (9), pp. e23421. Date of Electronic Publication: 2023 Jun 22.

BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancer.

Autor: Raimundo L; LAQV/REQUIMTE, Department of Biological Sciences, Laboratory of Microbiology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal., Paterna A; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisbon, 1649-003, Portugal., Calheiros J; LAQV/REQUIMTE, Department of Biological Sciences, Laboratory of Microbiology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal., Ribeiro J; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisbon, 1649-003, Portugal., Cardoso DSP; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisbon, 1649-003, Portugal., Piga I; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV, IRCCS, Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, 35128, Italy., Neto SJ; Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, 4200-135, Portugal.; Institute for Research and Innovation in Health (i3S), University of Porto, Rua Alfredo Allen, Porto, 4200-135, Portugal.; Faculty of Medicine, University of Porto, Praça de Gomes Teixeira, Porto, 4099-002, Portugal., Hegan D; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, CT06511, USA.; Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, CT06511, USA., Glazer PM; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, CT06511, USA.; Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, CT06511, USA., Indraccolo S; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV, IRCCS, Padova, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, 35128, Italy., Mulhovo S; Centro de Estudos Moçambicanos e de Etnociências (CEMEC), Faculty of Natural Sciences and Mathematics, Pedagogical University, Maputo, 21402161, Mozambique., Costa JL; Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Porto, 4200-135, Portugal.; Institute for Research and Innovation in Health (i3S), University of Porto, Rua Alfredo Allen, Porto, 4200-135, Portugal.; Faculty of Medicine, University of Porto, Praça de Gomes Teixeira, Porto, 4099-002, Portugal., Ferreira MU; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisbon, 1649-003, Portugal., Saraiva L; LAQV/REQUIMTE, Department of Biological Sciences, Laboratory of Microbiology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2021 Sep; Vol. 178 (18), pp. 3627-3647. Date of Electronic Publication: 2021 Jun 11.

Alkylated monoterpene indole alkaloid derivatives as potent P-glycoprotein inhibitors in resistant cancer cells.

Autor: Cardoso DSP; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal., Kincses A; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, H-6720, Szeged, Hungary., Nové M; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, H-6720, Szeged, Hungary., Spengler G; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, H-6720, Szeged, Hungary., Mulhovo S; Centro de Estudos Moçambicanos e de Etnociências (CEMEC), Faculdade de Ciências Naturais e Matemática, Universidade Pedagógica Campus de Lhanguene, Av. de Moçambique, 21402161, Maputo, Mozambique., Aires-de-Sousa J; LAQV and REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516, Caparica, Portugal., Dos Santos DJVA; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal; LAQV@REQUIMTE/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007, Porto, Portugal., Ferreira MU; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal. Electronic address: mjuferreira@ff.ulisboa.pt.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2021 Jan 15; Vol. 210, pp. 112985. Date of Electronic Publication: 2020 Nov 04.

Impact of V9302, a Competitive Antagonist of Transmembrane Glutamine Flux on Reversal of Resistance in Breast Cancer Cell Lines.

Autor: Szemerédi, Nikoletta¹ (AUTHOR) szemeredi.nikoletta@med.u-szeged.hu, Schelz, Zsuzsanna² (AUTHOR) schelz.zsuzsanna@szte.hu, Horvath, Dária Antónia¹ (AUTHOR) balintracz95@gmail.com, Rácz, Bálint¹ (AUTHOR), Szatmári, András G.¹ (AUTHOR), Muddather, Hiba F.² (AUTHOR) hiba.161991@hotmail.com, Bózsity, Noémi² (AUTHOR) bozsity-farago.noemi@szte.hu, Zupkó, István² (AUTHOR) zupko.istvan@szte.hu, Spengler, Gabriella¹ (AUTHOR) zupko.istvan@szte.hu

Publikováno v: Pharmaceutics. Jul2024, Vol. 16 Issue 7, p877. 14p.

New efflux pump inhibitors in Gram positive bacteria strains and cancer cells from an African medicinal plant

Autor: Ramalhete, C, Spengler, G, Serly, J, Duarte, N, Mulhovo, S, Amaral, L, Molnár, J, Ferreira, MJU

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::616c53f5f2f1869ee79077c818e3a059
https://hdl.handle.net/10451/22067