Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression: A Randomized Clinical Trial.

Autor: Milak MS; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.; Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York., Rashid R; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.; Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York., Dong Z; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.; Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York., Kegeles LS; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.; Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York.; Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, New York., Grunebaum MF; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.; Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York., Ogden RT; Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York.; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York., Lin X; Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York.; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York., Mulhern ST; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.; Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York., Suckow RF; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.; Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York.; Analytical Psychopharmacology Laboratory, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York., Cooper TB; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.; Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York.; Analytical Psychopharmacology Laboratory, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York., Keilp JG; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.; Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York., Mao X; Department of Radiology, Weill Cornell Medicine, New York, New York., Shungu DC; Department of Radiology, Weill Cornell Medicine, New York, New York., Mann JJ; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.; Molecular Imaging and Neuropathology Division, The New York State Psychiatric Institute, New York.; Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, New York.

Publikováno v: JAMA network open [JAMA Netw Open] 2020 Aug 03; Vol. 3 (8), pp. e2013211. Date of Electronic Publication: 2020 Aug 03.

A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder.

Autor: Milak MS; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA.; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, USA., Proper CJ; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA., Mulhern ST; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA., Parter AL; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA., Kegeles LS; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA.; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, USA., Ogden RT; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA.; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, USA.; Department of Biostatistics, Columbia University, Mailman School of Public Health, New York, NY, USA., Mao X; Department of Radiology, Weill Medical College of Cornell University, New York, NY, USA., Rodriguez CI; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA.; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, USA., Oquendo MA; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA.; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, USA., Suckow RF; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, USA.; Analytical Psychopharmacology Laboratory, the Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA., Cooper TB; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, USA.; Analytical Psychopharmacology Laboratory, the Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA., Keilp JG; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA.; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, USA., Shungu DC; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, USA.; Department of Radiology, Weill Medical College of Cornell University, New York, NY, USA., Mann JJ; Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA.; Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, USA.; Department of Radiology, Columbia University, College of Physicians and Surgeons, New York, NY, USA.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2016 Mar; Vol. 21 (3), pp. 320-7. Date of Electronic Publication: 2015 Aug 18.

Increase in thalamic cerebral blood flow is associated with antidepressant effects of ketamine in major depressive disorder.

Autor: Gärtner, Matti^1,2 (AUTHOR), de Rover, Mischa^3,4 (AUTHOR), Václavů, Lena⁵ (AUTHOR), Scheidegger, Milan⁶ (AUTHOR), van Osch, Matthias J. P.⁵ (AUTHOR), Grimm, Simone^1,2,6 (AUTHOR)

Publikováno v: World Journal of Biological Psychiatry. Oct2022, Vol. 23 Issue 8, p643-652. 10p.

Acute effects of ketamine on the pregenual anterior cingulate: linking spontaneous activation, functional connectivity, and glutamate metabolism.

Autor: Gärtner, Matti^1,2 (AUTHOR) matti.gaertner@medicalschool-berlin.de, Weigand, Anne¹ (AUTHOR), Scheidegger, Milan³ (AUTHOR), Lehmann, Mick³ (AUTHOR), Wyss, Patrik O.⁴ (AUTHOR), Wunder, Andreas⁵ (AUTHOR), Henning, Anke⁶ (AUTHOR), Grimm, Simone^1,2,3 (AUTHOR)

Publikováno v: European Archives of Psychiatry & Clinical Neuroscience. Jun2022, Vol. 272 Issue 4, p703-714. 12p. 3 Color Photographs, 3 Charts, 2 Graphs.

The potential of 1H-MRS in CNS drug development.

Autor: Egerton, Alice¹ (AUTHOR) Alice.Egerton@kcl.ac.uk

Publikováno v: Psychopharmacology. May2021, Vol. 238 Issue 5, p1241-1254. 14p. 1 Black and White Photograph, 2 Charts.