A Novel Murine GITR Ligand Fusion Protein Induces Antitumor Activity as a Monotherapy That Is Further Enhanced in Combination with an OX40 Agonist.

Autor: Leyland R; MedImmune Ltd., Granta Park, Cambridge, United Kingdom., Watkins A; MedImmune Ltd., Granta Park, Cambridge, United Kingdom., Mulgrew KA; MedImmune LLC, One MedImmune Way, Gaithersburg, Maryland., Holoweckyj N; MedImmune LLC, One MedImmune Way, Gaithersburg, Maryland., Bamber L; MedImmune Ltd., Granta Park, Cambridge, United Kingdom., Tigue NJ; MedImmune Ltd., Granta Park, Cambridge, United Kingdom., Offer E; MedImmune Ltd., Granta Park, Cambridge, United Kingdom., Andrews J; MedImmune Ltd., Granta Park, Cambridge, United Kingdom., Yan L; MedImmune LLC, Mountain View, California., Mullins S; MedImmune Ltd., Granta Park, Cambridge, United Kingdom., Oberst MD; MedImmune LLC, One MedImmune Way, Gaithersburg, Maryland., Coates Ulrichsen J; MedImmune Ltd., Granta Park, Cambridge, United Kingdom., Leinster DA; MedImmune Ltd., Granta Park, Cambridge, United Kingdom., McGlinchey K; MedImmune LLC, One MedImmune Way, Gaithersburg, Maryland., Young L; MedImmune Ltd., Granta Park, Cambridge, United Kingdom., Morrow M; MedImmune Ltd., Granta Park, Cambridge, United Kingdom., Hammond SA; MedImmune LLC, One MedImmune Way, Gaithersburg, Maryland., Mallinder P; MedImmune Ltd., Granta Park, Cambridge, United Kingdom., Herath A; MedImmune Ltd., Granta Park, Cambridge, United Kingdom., Leow CC; MedImmune LLC, One MedImmune Way, Gaithersburg, Maryland., Wilkinson RW; MedImmune Ltd., Granta Park, Cambridge, United Kingdom. wilkinsonr@medimmune.com., Stewart R; MedImmune Ltd., Granta Park, Cambridge, United Kingdom.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2017 Jul 01; Vol. 23 (13), pp. 3416-3427. Date of Electronic Publication: 2017 Jan 09.