Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mularski, Christian J."'
Autor:
Kelvin Cooper, Karen W. Hoover, Christine A. Kennedy, Wester Ronald Thure, Michael L. Mangiapane, Donald L. Bussolotti, Helen Berke, Mularski Christian J, Paul Da Silva Jardine, Albert L. Rauch, Janet A. LaFlamme, Philip A. Carpino, Michael Burkard, Charles E. Aldinger, George T. Magnus-Ayritey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:133-138
The syntheses and biological activities of dihydropyridine angiotensin II (AII) antagonists are described. Compounds such as 12 are examples of a new, structurally distinct class of AT(in1-selective agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef80cfada0f40be71605d888f8d48bb2
https://doi.org/10.1016/s0960-894x(01)81135-5
https://doi.org/10.1016/s0960-894x(01)81135-5
Autor:
William H. Martin, Victor F. Soliman, Lawrence M. Zaccaro, Lorraine D. Shelly, Diane M. Hargrove, Stephen F. Petras, H. James Harwood, Deepak Dalvie, Mularski Christian J, W. Ross Tracey, Michael Raymond Makowski, William P. Magee, Justin Chapman, Kelly A. Martin, Shane A. Eisenbeis, David Austen Perry
Publikováno v:
The Journal of biological chemistry. 278(39)
Inhibition of acetyl-CoA carboxylase (ACC), with its resultant inhibition of fatty acid synthesis and stimulation of fatty acid oxidation, has the potential to favorably affect the multitude of cardiovascular risk factors associated with the metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb98042320064c52c59d1309eac8aab
https://pubmed.ncbi.nlm.nih.gov/12842871
https://pubmed.ncbi.nlm.nih.gov/12842871
Autor:
Ravi B. Marala, Allan R. Buchholz, Delvin R. Knight, Scott P. Kennedy, Wester Ronald Thure, Paul J. Kowalczyk, Roger J. Hill, Roger B. Ruggeri, Angel Guzman-Perez, Ewell R. Cook, Mary C. Allen, Day Wesley Warren, Janice A. Brown, Mularski Christian J, William Albert Novomisle, W. Ross Tracey, Hamanaka Ernest S
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(6)
Zoniporide (CP-597,396) is a potent and selective inhibitor of NHE-1, which exhibits high aqueous solubility and acceptable pharmacokinetics for intravenous administration. The discovery, synthesis, activities, and rat and dog pharmacokinetics of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab46b1bc912c815842109bc5bf21715
https://pubmed.ncbi.nlm.nih.gov/11277524
https://pubmed.ncbi.nlm.nih.gov/11277524
Autor:
Guzman-Perez, Angel, Wester, Ronald T., Allen, Mary C., Brown, Janice A., Buchholz, Allan R., Cook, Ewell R., Day, Wesley W., Hamanaka, Ernest S., Kennedy, Scott P., Knight, Delvin R., Kowalczyk, Paul J., Marala, Ravi B., Mularski, Christian J., Novomisle, William A., Ruggeri, Roger B., Tracey, W.Ross, Hill, Roger J.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2001 11(6):803-807
Publikováno v:
The Journal of Organic Chemistry. 49:4800-4805
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e14f39bc653cc2c7dc0ac9f225b18f60
https://doi.org/10.1021/jo00199a010
https://doi.org/10.1021/jo00199a010
Publikováno v:
Tetrahedron. 44:3073-3078
The reaction of NPBDP with various guanidines affords, after formic acid hydrolysis, 2-amino-5-hydroxy-4-pyrimidones. Reaction of NPBDP with o-aminoheterocycles gives similar results. NPBDP is readily converted to the 3-amino-2-alkenenitrile, 10, a k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::560bb2096535437d9ed5b10570986bbf
https://doi.org/10.1016/s0040-4020(01)85939-1
https://doi.org/10.1016/s0040-4020(01)85939-1
Publikováno v:
Tetrahedron Letters. 25:2957-2960
5-Acetyl-2-aminooxazole, upon treatment with amines in the presence of water, affords good yields of 1H-5-acetyl-2-substituted amino-imidazoles, along witn varying amounts of the corresponding 5-hydroxy-4-methyl-2-substituted aminopyrimidines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::363f0952497afb23dafff2d9d1106d44
https://doi.org/10.1016/s0040-4039(01)81336-8
https://doi.org/10.1016/s0040-4039(01)81336-8
Publikováno v:
Tetrahedron Letters. 24:2059-2062
The synthesis of p -nitrophenyl 3-bromo-2,2-diethoxypropionate, and its chemoselective reactions for the preparation of highly functionalized small molecules and also novel heterocycles, are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b20910497eb868690e81bebdd88a9aee
https://doi.org/10.1016/s0040-4039(00)81843-2
https://doi.org/10.1016/s0040-4039(00)81843-2
Publikováno v:
The Journal of Organic Chemistry. 51:413-415
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98e4eb86c07b047bb4a4f9c265187287
https://doi.org/10.1021/jo00353a032
https://doi.org/10.1021/jo00353a032
Publikováno v:
ChemInform. 19
The reaction of NPBDP with various guanidines affords, after formic acid hydrolysis, 2-amino-5-hydroxy-4-pyrimidones. Reaction of NPBDP with o-aminoheterocycles gives similar results. NPBDP is readily converted to the 3-amino-2-alkenenitrile, 10, a k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57c5d569455de6039664beae48490a10
https://doi.org/10.1002/chin.198844199
https://doi.org/10.1002/chin.198844199