Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mukund Mehrotra"'
Autor:
Lisa Alaimo, Mukund Mehrotra, Mark S. Smyth, Joseph M. Seroogy, Gerd Ruhter, Jack W. Rose, Gary Park, Julie Anne Heath, Deborah Volkots, Theo Schotten, Robert M. Scarborough, Anjali Pandey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1103-1107
The synthesis and biological activity of analogues containing spiro piperidinylpyridine and pyrrolidinylpyridine templates are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spiro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15d464cd411ab812697d7726beff49a
https://doi.org/10.1016/s0960-894x(02)00095-1
https://doi.org/10.1016/s0960-894x(02)00095-1
Autor:
Anjali Pandey, Theo Schotten, Joseph M. Seroogy, Julie Anne Heath, Deborah Volkots, Gerd Ruhter, Mukund Mehrotra, Jack W. Rose, Robert M. Scarborough, Mark S. Smyth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1293-1296
The synthesis and biological activity of novel glycoprotein IIb–IIIa anatagonists containing 3-azaspiro[5.5]undec-9-yl nucleus are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b18b0062b238c9d17a8337d2dc7e8c61
https://doi.org/10.1016/s0960-894x(01)00216-5
https://doi.org/10.1016/s0960-894x(01)00216-5
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1941-1946
The phosphopeptide 1 is a potent inhibitor of pp60 c-src SH2 domain mediated phosphoprotein interactions (IC 50 ≤ 0.5 μM), but lacks cell permeability. The syntheses of its less charged analogs 2 and 3 are described, in which the arginine-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5256d958841c16bba739e2feace5344b
https://doi.org/10.1016/0960-894x(96)00349-6
https://doi.org/10.1016/0960-894x(96)00349-6
Autor:
Robert M. Scarborough, Gerd Ruhter, Julie Anne Heath, Anjali Pandey, Mark S. Smyth, Mukund Mehrotra, J. Seroogy, Jack W. Rose, Theo Schotten, Deborah Volkots
Publikováno v:
ChemInform. 32
The synthesis and biological activity of novel glycoprotein IIb–IIIa antagonists containing the 3,9-diazaspiro[5.5]undecane nucleus are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::103fb6ddd447e78407e22ff67281a5bc
https://doi.org/10.1002/chin.200137244
https://doi.org/10.1002/chin.200137244
Autor:
Athiwat Hutchaleelaha, Jin-Chen Yu, Neill A. Giese, Shannon Chi, Julie Anne Heath, Robert M. Scarborough, Anjali Pandey, Mukund Mehrotra, Stanley J. Hollenbach
Publikováno v:
ChemInform. 36
4-[4-(N-Substituted-thio-carbamoyl)-1-piperazinyl]-6-methoxy-7-alkoxyamino-quinazoline derivatives such as 14 (CT53986) have been identified to be potent and selective inhibitors of the phosphorylation of PDGFR. SAR-investigations are described in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93920d973e997054362beb001464950c
https://doi.org/10.1002/chin.200503154
https://doi.org/10.1002/chin.200503154
Autor:
Mukund Mehrotra, Robert M. Scarborough, Gary L. Park, Deborah Volkots, Jack W. Rose, Joseph L. Lambing, Anjali Pandey, Julie Anne Heath, Joseph M. Seroogy, Stanley J. Hollenbach, Mark S. Smyth, Lisa Nannizzi-Alaimo
Publikováno v:
Journal of medicinal chemistry. 47(8)
In our efforts to develop orally active GPIIb-IIIa antagonists with improved pharmaceutical properties, we have utilized a novel 2,8-diazaspiro[4.5]decane scaffold as a template. We describe here our investigation of a variety of templates including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5204cd6f8ac6564f5791a45cba87ec
https://pubmed.ncbi.nlm.nih.gov/15056002
https://pubmed.ncbi.nlm.nih.gov/15056002
Autor:
Srinivasa K. Prasad, Michael H. Tomasson, Robert M. Scarborough, David R. Phillips, Patrick Nestor, Mukund Mehrotra, Suzanne J. Bakewell, Keith Abe, Nikki Dowland, James Kanter, Katherine N. Weilbaecher
Mice with a targeted deletion of β 3 integrin were used to examine the process by which tumor cells metastasize and destroy bone. Injection of B16 melanoma cells into the left cardiac ventricle resulted in osteolytic bone metastasis in 74% of β 3 +
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42f9bba07daede2f8709a30de363ee6
https://europepmc.org/articles/PMC283570/
https://europepmc.org/articles/PMC283570/
Autor:
Mukund Mehrotra, Gerd Ruhter, Mark S. Smyth, Jack W. Rose, Robert M. Scarborough, Anjali Pandey, J. Seroogy, Deborah Volkots, Theo Schotten, Julie Anne Heath
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(10)
The synthesis and biological activity of novel glycoprotein IIb–IIIa antagonists containing the 3,9-diazaspiro[5.5]undecane nucleus are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a150233e9dc618cd3510de02764a8b
https://pubmed.ncbi.nlm.nih.gov/11392539
https://pubmed.ncbi.nlm.nih.gov/11392539
Autor:
Athiwat Hutchaleelaha, Shannon Chi, Julie Anne Heath, Robert M. Scarborough, Mukund Mehrotra, Stanley J. Hollenbach, Jin-Chen Yu, Neil A. Giese, Anjali Pandey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:6133-6133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e0ff3f190ad5d89b877ca62e13729cd
https://doi.org/10.1016/s0960-894x(04)01229-6
https://doi.org/10.1016/s0960-894x(04)01229-6
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 77(11)
10,10-Difluoro-13,14-dehydroprostacyclin was compared with natural prostacyclin (prostaglandin I2, PGI2) for vascular relaxing activity in vitro on helical strips of small canine mesenteric arteries (outside diameter < 1 mm) and bovine coronary arter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab098595e5f31abd3df6b050374186b
https://pubmed.ncbi.nlm.nih.gov/7005902
https://pubmed.ncbi.nlm.nih.gov/7005902