Zobrazeno 1 - 10 of 268 pro vyhledávání: '"Mukund K. Gurjar"'
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Akademický článek
A synthesis of (±)-thia-calanolide A, its resolution and in vitro biological evaluation
Autor: Anil U. Chopade, Manojkumar U. Chopade, Bhanu M. Chanda, Dilip D. Sawaikar, Kiran B. Sonawane, Mukund K. Gurjar
Publikováno v: Arabian Journal of Chemistry, Vol 9, Iss S2, Pp S1597-S1602 (2016)
A synthesis of (±)-thia-calanolide A 3 has been successfully accomplished starting from 3,5-dimethoxythiophenol 4, in six steps in an overall yield of 4.5%. The key reaction involved Friedel–Crafts tigloylation of 5,7-dihydroxy-4-n-propyl thiocoum
Externí odkaz: https://doaj.org/article/838ec68b32654374b10ed01f7e56019b
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5
A synthesis of (±)-thia-calanolide A, its resolution and in vitro biological evaluation
Autor: D. D. Sawaikar, Mukund K. Gurjar, Manojkumar U. Chopade, Kiran B. Sonawane, Bhanu M. Chanda, Anil U. Chopade
Publikováno v: Arabian Journal of Chemistry, Vol 9, Iss S2, Pp S1597-S1602 (2016)
Arabian Journal of Chemistry
A synthesis of (±)-thia-calanolide A 3 has been successfully accomplished starting from 3,5-dimethoxythiophenol 4, in six steps in an overall yield of 4.5%. The key reaction involved Friedel–Crafts tigloylation of 5,7-dihydroxy-4-n-propyl thiocoum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf23c3d75812719bfc2dfe1bf8780d83
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6
An Efficient, Scalable Process for Benzphetamine Hydrochloride
Autor: Rangarao Kolla, Mukund G. Kulkarni, Narendra Kumar Tripathy, Chinmoy Pramanik, Srinivasarao Sompalli, Kiran Bapat, Ashok Chaudhari, Mukund K. Gurjar
Publikováno v: Organic Process Research & Development. 18:495-500
Commercial manufacturing of benzphetamine hydrochloride along with its impurity profiling is disclosed. Deoxygenation of pseudoephedrine is reported with ∼100% retention by shielding the amine group as its tert-butyl carbamate, which is very straig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c985ab92f6dfe27ee0f5789a64ede391
https://doi.org/10.1021/op400313y
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7
Commercial Manufacturing of Propofol: Simplifying the Isolation Process and Control on Related Substances
Autor: Mukund K. Gurjar, Narendra Kumar Tripathy, Sandeep Kotharkar, Yogesh More, Tushar P. Khaladkar, Balaji Vasant Chaugule, Kaliaperumal Neelakandan, Ashok Chaudhari, Ajit S. Borhade, Mukund G. Kulkarni, Chinmoy Pramanik, Pradip Patil, Dinkar Gotrane
Publikováno v: Organic Process Research & Development. 18:152-156
A commercially viable manufacturing process for propofol (1) is described. The process avoids acid–base neutralization events during isolation of intermediate, 2,6-di-isopropylbenzoic acid (3) and crude propofol, and thus simplifies the synthesis o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::632cf15dc5d8124ed5277465d1e0dc88
https://doi.org/10.1021/op400300t
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8
A New Solvent System (Cyclopentyl Methyl Ether–Water) in Process Development of Darifenacin HBr
Autor: Chinmoy Pramanik, Kiran Bapat, Mukund K. Gurjar, Ashok Chaudhari, Narendra Kumar Tripathy
Publikováno v: Organic Process Research & Development. 16:1591-1597
Darifenacin is a potent and competitive M3 selective receptor antagonist (M3SRA), and its hydrobromide salt (1) is the active ingredient of pharmaceutical formulations for oral treatment of urinary incontinence. The present work demonstrates an effic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bdc716a2fa91f87f4fed71472c5f63b
https://doi.org/10.1021/op300119s
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9
Identification, Synthesis, and Strategy For Minimization of Potential Impurities Observed In Raltegravir Potassium Drug Substance
Autor: Swapnil Panditrao Sonawane, Ashok Chaudhari, Mukund K. Gurjar, Shivnath B. Shinde, Mangesh S. Deshpande, Siddheshwar W. Kshirsagar, Golak C. Maikap, Gulabrao D. Patil, Pankaj Shallkrao Patil
Publikováno v: Organic Process Research & Development. 16:1422-1429
Multiple sources of anticipated degradation and process impurities of raltegravir potassium drug substance observed during the laboratory optimization and later during its bulk synthesis are described in this article. The impurities were monitored by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::018f6f8ef876d60182326947047b72df
https://doi.org/10.1021/op300077m
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