Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mukul Tewary"'
Autor:
Himanshu Kaul, Nicolas Werschler, Ross D. Jones, M. Mona Siu, Mukul Tewary, Andrew Hagner, Joel Ostblom, Daniel Aguilar-Hidalgo, Peter W. Zandstra
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 377-393 (2023)
Summary: The mechanism by which morphogenetic signals engage the regulatory networks responsible for early embryonic tissue patterning is incompletely understood. Here, we developed a minimal gene regulatory network (GRN) model of human pluripotent s
Externí odkaz:
https://doaj.org/article/79cd57f0bba247fab7f9da091408879f
Autor:
Dominika Dziedzicka, Mukul Tewary, Alexander Keller, Laurentijn Tilleman, Laura Prochazka, Joel Östblom, Edouard Couvreu De Deckersberg, Christina Markouli, Silvie Franck, Filip Van Nieuwerburgh, Claudia Spits, Peter W. Zandstra, Karen Sermon, Mieke Geens
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Low differentiation propensity towards a targeted lineage can significantly hamper the utility of individual human pluripotent stem cell (hPSC) lines in biomedical applications. Here, we use monolayer and micropatterned cell cultures, as wel
Externí odkaz:
https://doaj.org/article/9e385811ab3744d7a6a8dfcfa4c06319
Autor:
Nafees Rahman, Patrick M. Brauer, Lilian Ho, Tatiana Usenko, Mukul Tewary, Juan Carlos Zúñiga-Pflücker, Peter W. Zandstra
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The derivation of blood progenitor cells from human pluripotent stem cells is of interest for cell therapy but remains an inefficient process. Here the authors micropattern hPSC-derived haemogenic endothelial (HE) cells into spatially-organized, size
Externí odkaz:
https://doaj.org/article/00d82a9048724b09bcacb76efe643c61
Autor:
Mukul Tewary, Dominika Dziedzicka, Joel Ostblom, Laura Prochazka, Nika Shakiba, Tiam Heydari, Daniel Aguilar-Hidalgo, Curtis Woodford, Elia Piccinini, David Becerra-Alonso, Alice Vickers, Blaise Louis, Nafees Rahman, Davide Danovi, Mieke Geens, Fiona M Watt, Peter W Zandstra
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000081 (2019)
In vitro models of postimplantation human development are valuable to the fields of regenerative medicine and developmental biology. Here, we report characterization of a robust in vitro platform that enabled high-content screening of multiple human
Externí odkaz:
https://doaj.org/article/3d54779845f24e319469e56edbe389d3
Autor:
Alessandra Vigilante, Anna Laddach, Nathalie Moens, Ruta Meleckyte, Andreas Leha, Arsham Ghahramani, Oliver J. Culley, Annie Kathuria, Chloe Hurling, Alice Vickers, Erika Wiseman, Mukul Tewary, Peter W. Zandstra, Richard Durbin, Franca Fraternali, Oliver Stegle, Ewan Birney, Nicholas M. Luscombe, Davide Danovi, Fiona M. Watt
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 2078-2087.e3 (2019)
Summary: Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a potentially powerful tool for investigating the relationship between genetic variants and cellular behavior. Here, we integrate high content imaging of c
Externí odkaz:
https://doaj.org/article/e47a80c1787e4bf88999cbaafa6e98f8
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 1, p e1006384 (2019)
A growing body of evidence highlights the importance of the cellular microenvironment as a regulator of phenotypic and functional cellular responses to perturbations. We have previously developed cell patterning techniques to control population conte
Externí odkaz:
https://doaj.org/article/f1d8ea06866949abb447ed3c5b8ae183
Autor:
Daniel Aguilar-Hidalgo, Joel Ostblom, M Mona Siu, Benjamin McMaster, Tiam Heydari, Nicolas Werschler, Mukul Tewary, Peter Zandstra
The emergence of the anterior-posterior body axis during early gastrulation constitutes a symmetry-breaking event, which is key to the development of bilateral organisms, and its mechanism remains poorly understood. Two-dimensional gastruloids consti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cce57fad766c4eb4442a463dcb7fcf8
https://doi.org/10.1101/2022.12.20.521167
https://doi.org/10.1101/2022.12.20.521167
Autor:
Alice Vickers, Martina Poletti, Anna Laddach, Vasiliki Salameti, Mukul Tewary, Franca Fraternali, Fiona M. Watt, Davide Danovi
Publikováno v:
Stem Cell Reports
Summary Quantitative analysis of human induced pluripotent stem cell (iPSC) lines from healthy donors is a powerful tool for uncovering the relationship between genetic variants and cellular behavior. We previously identified rare, deleterious non-sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc82dcb9d677415715b902a20d5e34b5
https://doi.org/10.1016/j.stemcr.2021.09.017
https://doi.org/10.1016/j.stemcr.2021.09.017
Autor:
Himanshu Kaul, Nicolas Werschler, Ross D. Jones, M. Mona Siu, Mukul Tewary, Andrew Hagner, Joel Ostblom, Daniel Aguilar-Hidalgo, Peter W. Zandstra
Publikováno v:
Stem cell reports.
The mechanism by which morphogenetic signals engage the regulatory networks responsible for early embryonic tissue patterning is incompletely understood. Here, we developed a minimal gene regulatory network (GRN) model of human pluripotent stem cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68201ec864ba33f30f319658e642a228
https://pubmed.ncbi.nlm.nih.gov/36332630
https://pubmed.ncbi.nlm.nih.gov/36332630
Autor:
Blaise Louis, Mukul Tewary, Andrew W. Bremer, Christina Philippeos, Victor A. Negri, Sebastiaan Zijl, Zev J. Gartner, David V. Schaffer, Fiona M. Watt
Publikováno v:
Acta biomaterialia. 150
The balance between stem cell renewal and differentiation is determined by the interplay between intrinsic cellular controls and extrinsic factors presented by the microenvironment, or 'niche'. Previous studies on cultured human epidermis have utilis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bbb1cd85b24d8dbca2c8faef864d3c0
https://pubmed.ncbi.nlm.nih.gov/35926780
https://pubmed.ncbi.nlm.nih.gov/35926780