Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Mukti H. Sarma"'
Publikováno v:
International Journal of Quantum Chemistry. 18:1-10
Nuclear magnetic resonance studies indicate that the drug lucanthone forms intercalated complexes with the synthetic DNA poly(dA-dT)-poly (dA-dT). In the intercalated complex the long axis of the drug is perpendicular to the helix axis and parallel t
Publikováno v:
International Journal of Quantum Chemistry. 36:17-33
A summary of 1D/2D-NMR studies on d(GA4T4C)2, d(GA4U4C)2, and d(GT4A4C)2 in solution is reported in this article. Results of these studies indicate one important structural property of A - T pairs, i.e., A - T pairs are propeller twisted, which resul
Publikováno v:
International Journal of Quantum Chemistry. 28:183-199
A procedure involving the combined use of NOE measurements, chemical shift shielding calculations, and stereochemical model building is discussed to determine the solution conformation of nucleic acids. Using this procedure it is shown that the DNA,
Autor:
Ramaswamy H. Sarma, Edward N. Trifonov, Victor B. Zhurkin, Victor I. Danilov, Maxim D. Frank-Kamenetskii, Mukti H. Sarma
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 31:125-127
Valery (Chrom) Ivanov In memoriam Maxim Frank-Kamenetskii a , Edward Trifonov b , Victor Zhurkin c , Victor Danilov d , Mukti Sarma e & Ramaswamy Sarma e a Department of Biomedical Engineering, Boston University, Boston, MA, USA b Institute of Evolut
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 20:751-758
In this manuscript, the procedure of molecular dynamics simulated annealing is applied to locate a probable receptor and binding site of a cyclicpeptide that inhibits estrogen-stimulated proliferation of breast cancer. The hydrophilic cyclopeptide EM
Autor:
Masayuki Shibata, Rejadra P. Ojha, Madan M. Dhingra, Christopher J. Turner, Margaret Farrar, Mukti H. Sarma, Ramaswamy H. Sarma
Publikováno v:
European Journal of Biochemistry. 265:35-53
Although DNA bending plays a crucial role in several biological processes, very little is known experimentally about the relationship between sugar phosphate conformation and sequence directed bending. In this paper, we determine the coupling constan
Publikováno v:
FEBS Letters. 418:76-82
Investigation of the width of the minor groove using 500 MHz NMR spectroscopy in three closely related 11-mer B-DNA duplexes shows that the minor groove is narrow in a GC rich oligonucleotide, and that a narrow minor groove is not something endemic t
Autor:
Robert F. Setlik, Masayuki Shibata, Robert Rein, Thomas B. Tomasi, Rick L. Ornstein, A. L. Kazim, Mukti H. Sarma, Ramaswamy H. Sarma
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 13:515-522
Here we describe a possible model of the cleavage mechanism in the hammerhead ribozyme. In this model, the 2' hydroxyl of C17 is moved into an appropriate orientation for an in-line attack on the G1.1 phosphate through a change in its sugar pucker fr
Autor:
Alfred Cairo, Rick L. Ornstein, Robert Rein, Thomas B. Tomasi, Robert S. Setlik, Masayuki Shibata, Mukti H. Sarma, A. Latif Kazim, Ramswamy H. Sarma
Publikováno v:
FEBS Letters. 357:317-323
Two hammerhead chimeric RNA/DNA ribozymes (HRz) were synthesized in pure form. Both were 30 nucleotides long, and the sequences were such that they could be targeted to cleave the HIV-1 gag RNA. Named HRz-W and HRz-M, the former had its invariable co
Autor:
Mukti H. Sarma, Ramaswamy H. Sarma
Publikováno v:
Journal of biomolecular structuredynamics. 15(6)
(1998). Structure, Motion, Interaction and Expression of Biological Macromolecules. Journal of Biomolecular Structure and Dynamics: Vol. 15, No. 5, pp. x-xiv.