Výsledky vyhledávání - "Mukta D. Khasnis"

Akademický článek

Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env.

Autor: Hannah M Schapiro, Mukta D Khasnis, Koree Ahn, Alexandra Karagiaridi, Stephanie Hayden, Maria E Cilento, Michael J Root

Publikováno v: PLoS Pathogens, Vol 18, Iss 5, p e1010531 (2022)

Glycoprotein Env of human immunodeficiency virus type 1 (HIV-1) mediates viral entry through membrane fusion. Composed of gp120 and gp41 subunits arranged as a trimer-of-heterodimers, Env adopts a metastable, highly dynamic conformation on the virion

Externí odkaz: https://doaj.org/article/b8a888b33e074c6baff1d6349fdf2cb1

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Akademický článek

Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer.

Autor: Mukta D Khasnis, Konstantine Halkidis, Anshul Bhardwaj, Michael J Root

Publikováno v: PLoS Pathogens, Vol 12, Iss 12, p e1006098 (2016)

Structural rearrangements of HIV-1 glycoprotein Env promote viral entry through membrane fusion. Env is a symmetric homotrimer with each protomer composed of surface subunit gp120 and transmembrane subunit gp41. Cellular CD4- and chemokine receptor-b

Externí odkaz: https://doaj.org/article/7d72ca12cbe04d619bbf70e3945e1df7

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Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env

Autor: Hannah M. Schapiro, Mukta D. Khasnis, Koree Ahn, Alexandra Karagiaridi, Stephanie Hayden, Maria E. Cilento, Michael J. Root

Publikováno v: PLoS pathogens. 18(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f12230437bdb93ec8b52cebdadf0f9
https://pubmed.ncbi.nlm.nih.gov/35584191

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Reconstituted Human Myosin Light Chain Phosphatase Reveals Distinct Roles of Two Inhibitory Phosphorylation Sites of the Regulatory Subunit, MYPT1

Autor: Kristyn Gumpper, Masumi Eto, Akiko Nakatomi, Mukta D. Khasnis

Publikováno v: Biochemistry

The myosin light chain phosphatase (MLCP) is a cytoskeleton-associated protein phosphatase-1 (PP1) holoenzyme and a RhoA/ROCK effector, regulating cytoskeletal reorganization. ROCK-induced phosphorylation of the MLCP regulatory subunit (MYPT1) at two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87e0f6cc03d3022ef0721dace356b12
http://europepmc.org/articles/PMC4010256

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Caffeine relaxes smooth muscle through actin depolymerization

Autor: Masumi Eto, Tracy Tazzeo, Luke J. Janssen, Mukta D. Khasnis, Anne-Marie Lauzon, Genevieve Bates, Horia N. Roman

Caffeine is sometimes used in cell physiological studies to release internally stored Ca2+. We obtained evidence that caffeine may also act through a different mechanism that has not been previously described and sought to examine this in greater det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a79d7149a938f396836db874a06fb0
https://europepmc.org/articles/PMC3774218/

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CD4 Binding Induces an Asymmetric Transition of HIV-1 Env from its Native Conformation into the Prehairpin Intermediate State

Autor: Anshul Bhardwaj, Mukta D. Khasnis, Konstantine Halkidis, Michael J. Root

Publikováno v: Biophysical Journal. (2):90a

HIV-1 membrane fusion is mediated by sequential binding of the viral homotrimeric Env (gp120/gp41) to cellular CD4 and chemokine receptor (CXCR4 or CCR5). These binding events coordinate conformational transitions of the gp41 trimer from its native c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5faf981ba6f9f234f2454ad8d36aa752

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