Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mukesh Kumar Venkat Ramani"'
Autor:
Rosamaria Y. Moreno, Kyle J. Juetten, Svetlana B. Panina, Jamie P. Butalewicz, Brendan M. Floyd, Mukesh Kumar Venkat Ramani, Edward M. Marcotte, Jennifer S. Brodbelt, Y. Jessie Zhang
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107581- (2023)
Summary: During eukaryotic transcription, RNA polymerase II undergoes dynamic post-translational modifications on the C-terminal domain (CTD) of the largest subunit, generating an information-rich PTM landscape that transcriptional regulators bind. T
Externí odkaz:
https://doaj.org/article/508e48fd4c6846dc911d42011f3bddbf
Publikováno v:
J Am Chem Soc
The critical role of site-specific phosphorylation in eukaryotic transcription has motivated efforts to decipher the complex phosphorylation patterns exhibited by the carboxyl-terminal domain (CTD) of RNA polymerase II. Phosphorylation remains a chal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadb001176e9ac99a576cf74247fa518
https://doi.org/10.1021/jacs.1c03321
https://doi.org/10.1021/jacs.1c03321
Autor:
Edwin E. Escobar, Jennifer S. Brodbelt, Yan Zhang, R Yvette Moreno, Mukesh Kumar Venkat Ramani, Blase M LeBlanc
Publikováno v:
RSC Chemical Biology
RNA polymerase II (RNAP II) is one of the primary enzymes responsible for expressing protein-encoding genes and some small nuclear RNAs. The enigmatic carboxy-terminal domain (CTD) of RNAP II and its phosphorylation state are critically important in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fb60dae2ae1ab908835a9aa140f288
https://doi.org/10.1039/d1cb00083g
https://doi.org/10.1039/d1cb00083g
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::722d904a9b4724094b009adebb4c806a
https://doi.org/10.1096/fasebj.2021.35.s1.02644
https://doi.org/10.1096/fasebj.2021.35.s1.02644
Publikováno v:
J Mol Biol
The highly conserved C-terminal domain (CTD) of the largest subunit of RNA polymerase II comprises a consensus heptad (Y(1)S(2)P(3)T(4)S(5)P(6)S(7)) repeated multiple times. Despite the simplicity of its sequence, the essential CTD domain orchestrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d68e6ca338c1cb9fbea2fba8ad535f
https://europepmc.org/articles/PMC8184622/
https://europepmc.org/articles/PMC8184622/
Autor:
Edwin E. Escobar, Jamie P. Butalewicz, Haoyi Wu, Seema Irani, Joshua E. Mayfield, Meena Tadros, Jennifer S. Brodbelt, Yan Jessie Zhang, Mukesh Kumar Venkat Ramani, Victoria C. Cotham, Rosamaria Y. Moreno
Publikováno v:
ACS Chem Biol
The phosphorylation states of RNA polymerase II coordinate the process of eukaryotic transcription by recruitment of transcription regulators. The individual residues of the repetitive heptad of the C-terminal domain (CTD) of the biggest subunit of R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee83e328dbc5ab82b20770d0506fc49
https://europepmc.org/articles/PMC8018230/
https://europepmc.org/articles/PMC8018230/