Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mukesh K. Mahajan"'
Autor:
Juan A. Kochen Rossi, Ankita Mishra, Berk Aykut, Mautin Hundeyin, Deirdre Jill Cohen, Ece Bagdatlioglu, Atsuo Ochi, Wenyu Su, Joshua Leinwand, Pamela Nassau, Narendra Verma, Mohammed Khan, Jacqueline I. Kim, Nan Wu, Michael Reilly, James H. Thorpe, Aarif Ahsan, Fei Li, Varshini Vasudevaraja, George Miller, Allison M. Beal, Ting Chen, Wei Wang, John D. Lich, Pardeep S. Taunk, Mukesh K. Mahajan, Inedouye Yaboh, Dennis Adeegbe, Jingjing Wu, Philip A. Harris, John Bertin, Johana Gutierrez, Kwok-Kin Wong, Brian Diskin, Emma Kurz, Yue Wu, Christina Almonte, J. Mosley, Michael Glacken, Jill M. Marinis, Shivraj Savadkar
Publikováno v:
Cancer Cell. 38:585-590
Summary Pancreatic ductal adenocarcinoma (PDA) is characterized by immune tolerance and immunotherapeutic resistance. We discovered upregulation of receptor-interacting serine/threonine protein kinase 1 (RIP1) in tumor-associated macrophages (TAMs) i
Autor:
Bartholomew J. Votta, Michael Reilly, Linda N. Casillas, Robert W. Marquis, Rakesh Nagilla, Mukesh K. Mahajan, Demartino Michael P, John Bertin, Helen H. Sun, Elizabeth J. Rivera, Pamela A. Haile
Publikováno v:
Journal of Pharmaceutical Sciences. 109:3160-3171
Receptor Interacting Protein 2 (RIP2) kinase inhibitors have been reported for therapeutic opportunities in inflammatory bowel diseases such as Ulcerative Colitis and Crohn's disease. During lead optimization, team identified 4-aminoquinoline series
Autor:
Pamela A. Haile, Linda N. Casillas, Bartholomew J. Votta, Gren Z. Wang, Adam K. Charnley, Xiaoyang Dong, Michael J. Bury, Joseph J. Romano, John F. Mehlmann, Bryan W. King, Karl F. Erhard, Charles R. Hanning, David B. Lipshutz, Biva M. Desai, Carol A. Capriotti, Michelle C. Schaeffer, Scott B. Berger, Mukesh K. Mahajan, Michael A. Reilly, Rakesh Nagilla, Elizabeth J. Rivera, Helen H. Sun, John K. Kenna, Allison M. Beal, Michael T. Ouellette, Mike Kelly, Gillian Stemp, Máire A. Convery, Anna Vossenkämper, Thomas T. MacDonald, Peter J. Gough, John Bertin, Robert W. Marquis
Publikováno v:
Journal of Medicinal Chemistry. 62:6482-6494
Autor:
Stéphane Sautet, Emilie Jigorel, Nicolas Faucher, Jamel Meslamani, Lara Kathryn Leister, Pascal Grondin, Julie A. Cox, Bryan W. King, Pamela Nassau, Gemma Victoria White, Brad J. Geddes, Alain Claude-Marie Daugan, Helen H. Sun, Michael T. Ouellette, Pauline Lamoureux, Elizabeth J. Rivera, Scott B. Berger, James H. Thorpe, Philip A. Harris, J. Mosley, Susan E. Hutchinson, Frédéric Donche, John Bertin, Sandra J. Hoffman, Natalie Wellaway, Patrick M. Eidam, Paris Ward, Florent Potvain, Clark A. Sehon, Sebastien Andre Campos, Robert W. Marquis, Peter J. Gough, Mukesh K. Mahajan, Veronique Beneton, Jae U. Jeong, Michelle C. Schaeffer, John D. Lich, Allison M. Beal, Rakesh Nagilla, James Michael Woolven, Bonnie L. Hoffman, Anderson Niall Andrew, Marie-Hélène Fouchet, Deepak Bandyopadhyay, Carol A. Capriotti, Rachel D. Totoritis, Joshua N. Finger, Kishore K. Pasikanti, David D. Wisnoski, Sze-Ling Ng, Nino Campobasso, Nicolas George, Michael Reilly
Publikováno v:
Journal of Medicinal Chemistry. 62:5096-5110
RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently, RIP1 kinase inhibitors have advanced into early clinical
Autor:
Pamela A, Haile, Linda N, Casillas, Bartholomew J, Votta, Gren Z, Wang, Adam K, Charnley, Xiaoyang, Dong, Michael J, Bury, Joseph J, Romano, John F, Mehlmann, Bryan W, King, Karl F, Erhard, Charles R, Hanning, David B, Lipshutz, Biva M, Desai, Carol A, Capriotti, Michelle C, Schaeffer, Scott B, Berger, Mukesh K, Mahajan, Michael A, Reilly, Rakesh, Nagilla, Elizabeth J, Rivera, Helen H, Sun, John K, Kenna, Allison M, Beal, Michael T, Ouellette, Mike, Kelly, Gillian, Stemp, Máire A, Convery, Anna, Vossenkämper, Thomas T, MacDonald, Peter J, Gough, John, Bertin, Robert W, Marquis
Publikováno v:
Journal of medicinal chemistry. 62(14)
RIP2 kinase has been identified as a key signal transduction partner in the NOD2 pathway contributing to a variety of human pathologies, including immune-mediated inflammatory diseases. Small-molecule inhibitors of RIP2 kinase or its signaling partne
Autor:
Joshua N. Finger, Michael T. Ouellette, Helen H. Sun, Robert W. Marquis, Viera Kasparcova, James H. Thorpe, Scott B. Berger, Philip A. Harris, Rakesh Nagilla, George Miller, Anirudh Chirala, James Kang, Elizabeth J. Rivera, John Bertin, Peter J. Gough, Mukesh K. Mahajan, Daohua Zhang, John D. Lich, Julie A. Cox, Wei Wang, Lara Kathryn Leister, Jill M. Marinis, Rachel D. Totoritis, Patrick M. Eidam, Michael Reilly, Jae U. Jeong, Dongling Wu, Alan R. Rendina
Publikováno v:
ACS Medicinal Chemistry Letters
'ACS Medicinal Chemistry Letters ', vol: 10, pages: 857-862 (2019)
'ACS Medicinal Chemistry Letters ', vol: 10, pages: 857-862 (2019)
RIP1 regulates cell death and inflammation and is believed to play an important role in contributing to a variety of human pathologies, including immune-mediated inflammatory diseases and cancer. While small-molecule inhibitors of RIP1 kinase have be
Autor:
Elizabeth J. Rivera, Brian Donovan, Ami S. Lakdawala, Nikolay V. Plotnikov, Xiaoyang Dong, Barry S. Brown, Robert Singhaus, Khuram W. Chaudhary, Rachel D. Totoritis, Adam Kenneth Charnley, Michael Reilly, Terry Vincent Hughes, Joseph J. Romano, Pamela A. Haile, Robert W. Marquis, Michael Jonathan Bury, John F. Mehlmann, Gren Z. Wang, Rakesh Nagilla, Bartholomew J. Votta, Barbara A. Swift, Linda N. Casillas, Demartino Michael P, Peter J. Gough, Mukesh K. Mahajan, Carol A. Capriotti, Biva M. Desai, Scott B. Berger, Carol LePage, Helen H. Sun, David B. Lipshutz, John Bertin, Máire A. Convery, Chaya Duraiswami, Michael T. Ouellette
Publikováno v:
ACS Medicinal Chemistry Letters. 11:1353-1353
Autor:
Rachel D. Totoritis, Robert Singhaus, Brian Donovan, Nikolay V. Plotnikov, John F. Mehlmann, Terry Vincent Hughes, Michael Jonathan Bury, Pamela A. Haile, Khuram W. Chaudhary, Gren Z. Wang, Peter J. Gough, Biva M. Desai, Michael T. Ouellette, Michael Reilly, Mukesh K. Mahajan, Barry S. Brown, Scott B. Berger, Xiaoyang Dong, Carol A. Capriotti, Carol LePage, Bartholomew J. Votta, Helen H. Sun, David B. Lipshutz, John Bertin, Joseph J. Romano, Adam Kenneth Charnley, Ami S. Lakdawala, Robert W. Marquis, Barbara A. Swift, Rakesh Nagilla, Máire A. Convery, Demartino Michael P, Elizabeth J. Rivera, Linda N. Casillas
Publikováno v:
ACS Med Chem Lett
[Image: see text] RIP2 kinase was recently identified as a therapeutic target for a variety of autoimmune diseases. We have reported previously a selective 4-aminoquinoline-based RIP2 inhibitor GSK583 and demonstrated its effectiveness in blocking do
Autor:
Mukesh K. Mahajan, David Zhang, Jill M. Marinis, Robert W. Marquis, Steven Thomas, Michael Reilly, Lauren E. Richards-Peterson, Phil Harris, Debbie Tompson, Scott B. Berger, John Bertin
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S66-S67
Publikováno v:
Journal of pharmaceutical sciences. 100(2)
The incubation of oxymetazoline, a nonprescription nasal decongestant, with human liver microsomes (HLMs) supplemented with uridine-5-diphosphoglucuronic acid (UDPGA) generated glucuronide metabolite as observed by LC/MS/MS. The uridine glucuronosylt