Alteration in immuno-suppressive macrophage responses is associated with inhibition of vacuolar ATPase activity in breast cancer (TUM6P.968)

Autor: Gajendra Katara, Arpita Kulshrestha, Mukesh Jaiswal, Alice Gilman-Sachs, Kenneth Beaman

Publikováno v: The Journal of Immunology. 194:141.16-141.16

Vacuolar ATPases (V-ATPase) are important for tumor growth and metastasis. A novel, peptide of a2 isoform of V-ATPase (a2V) has been shown to have an immunoregulatory role in the tumor microenvironment by controlling the maturation of monocytes towar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4c45c137675db7b0f1955ea1516cbb6
https://doi.org/10.4049/jimmunol.194.supp.141.16

A Randomized, Double-Blind, Parallel-Group Phase III Trial Investigating the Glycemic Efficacy and Safety Profile of Fixed-Dose Combination Dapagliflozin and Linagliptin Over Linagliptin Monotherapy in Patients with Inadequately Controlled Type 2 Diabetes with Metformin

Autor: Jain, Aditi¹ (AUTHOR) jainaditik@gmail.com, Vispute, Abhay² (AUTHOR), Dange, Amol³ (AUTHOR), Naskar, Arindam⁴ (AUTHOR), Mondal, Asish⁵ (AUTHOR), Vivekanand, B.⁶ (AUTHOR), Sharma, Balram⁷ (AUTHOR), Varade, Deepak⁸ (AUTHOR), Shukla, Dhaiwat⁹ (AUTHOR), Bhatia, Girish¹⁰ (AUTHOR), Chaudhari, Harshal¹¹ (AUTHOR), Ram Babu, K.¹² (AUTHOR), Gavali, Onkar¹³ (AUTHOR), Sorate, Sanket¹⁴ (AUTHOR), Bhanushali, Shaishav¹⁵ (AUTHOR), Kothari, Vaibhav¹⁶ (AUTHOR), Khandelwal, Vipul¹⁷ (AUTHOR), Sharma, Akhilesh¹⁸ (AUTHOR), Pawar, Roshan¹⁸ (AUTHOR), Mayabhate, Mayur¹⁸ (AUTHOR)

Publikováno v: Diabetes Therapy. Jan2024, Vol. 15 Issue 1, p215-227. 13p.

Mammary epithelium‐specific inactivation of V‐ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer.

Autor: Katara, Gajendra K., Kulshrestha, Arpita, Mao, Liqun, Wang, Xin, Sahoo, Manoranjan, Ibrahim, Safaa, Pamarthy, Sahithi, Suzue, Kimiko, Shekhawat, Gajendra S., Gilman‐Sachs, Alice, Beaman, Kenneth D.

Publikováno v: Molecular Oncology; Feb2018, Vol. 12 Issue 2, p208-223, 16p

Abstract 4097: Vacuolar ATPase subunit a2 is associated with immunosuppression in cancer

Autor: Kenneth D. Beaman, Alice Gilman-Sachs, Gajendra K. Katara, Mukesh K. Jaiswal, Arpita Kulshrestha

Publikováno v: Cancer Research. 74:4097-4097

Macrophage polarization contributes to distinct human pathologies. In tumors, a polarized M2 phenotype called tumor-associated macrophages (TAMs), are associated with promotion of invasion and angiogenesis. In cancer cells, vacuolar ATPase (V-ATPase)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be3134fe93c452e16bef2915a7720c61
https://doi.org/10.1158/1538-7445.am2014-4097