Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mukandila Mulumba"'
Autor:
Stéphane Turcotte, Katia Mellal, Ramesh Chingle, Mukandila Mulumba, Samy Omri, Lylia Dif-Yaiche, Sylvain Chemtob, Huy Ong, William D. Lubell
Publikováno v:
Biomedicines, Vol 6, Iss 4, p 98 (2018)
Modulation of the cluster of differentiation-36 receptor (CD36) has proven promising for dampening pro-inflammatory macrophage signaling. For example, azapeptides (e.g., 1 and 2) bind CD36 selectively with high affinity, mitigate Toll-like receptor (
Externí odkaz:
https://doaj.org/article/1e4d6c5f99664b619bd18102e4c19a2d
Autor:
William D. Lubell, Ramesh Chingle, Huy Ong, Ragnhild G Ohm, Sylvain Chemtob, Mukandila Mulumba, Jinqiang Zhang, Ahsanullah
Publikováno v:
Journal of Medicinal Chemistry. 64:9365-9380
Cyclic peptide diversity has been broadened by elaborating the A3-macrocyclization to include various di-amino carboxylate components with different Ne-amine substituents. Triple-bond reduction provided new cyclic peptide macrocycles with Z-olefin an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b54fa0d7ff02f029f0a42f38cbcaf94f
https://doi.org/10.1021/acs.jmedchem.1c00642
https://doi.org/10.1021/acs.jmedchem.1c00642
Autor:
Yousra Hamdane, Suresh Vutla, Pradeep S. Chauhan, Mukandila Mulumba, William D. Lubell, Huy Ong
Publikováno v:
Organic Letters. 23:3491-3495
Fifteen N-aminoimidazolone (Nai) dipeptides having a variety of 5-position side-chain groups were synthesized by regioselective proline-catalyzed reactions of azopeptide and aldehyde components followed by acid-mediated dehydration of an aza-aspartat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1a0752cee062ae1cd7413599b810dd7
https://doi.org/10.1021/acs.orglett.1c00936
https://doi.org/10.1021/acs.orglett.1c00936
Autor:
Yousra, Hamdane, Pradeep S, Chauhan, Suresh, Vutla, Mukandila, Mulumba, Huy, Ong, William D, Lubell
Publikováno v:
Organic letters. 23(9)
Fifteen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c680208169fb275809bf450b318d5247
https://pubmed.ncbi.nlm.nih.gov/33886343
https://pubmed.ncbi.nlm.nih.gov/33886343
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
The retinal pigment epithelium (RPE) performs many functions that maintain photoreceptor health. Oxidative damage to the RPE is a critical component in the pathogenesis of eye diseases such as age-related macular degeneration (AMD). Ligands of the cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980a8a43d4d4b65bffa27e826955bfac
https://doaj.org/article/0d9b6499ec67446294ee30e61dedbfc0
https://doaj.org/article/0d9b6499ec67446294ee30e61dedbfc0
Autor:
Yesica Garcia Ramos, Hung Pham, Carl Fortin, Sylvain Chemtob, Houda Tahiri, Simon-Pierre Gravel, Maria Febbraio, Jinqiang Zhang, Katia Mellal, Sheetal Pundir, Florian Sennlaub, Pierre Hardy, Marie-France Dorion, Samy Omri, Jean-François Bouchard, Mukandila Mulumba, Jean-Sébastien Joyal, William D. Lubell, Huy Ong, Sylvie Marleau
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-49472-8⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-49472-8⟩
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-49472-8⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-49472-8⟩
In subretinal inflammation, activated mononuclear phagocytes (MP) play a key role in the progression of retinopathies. Little is known about the mechanism involved in the loss of photoreceptors leading to vision impairment. Studying retinal damage in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf34d08645ea9af4127cbefd244368e
https://hal.sorbonne-universite.fr/hal-02297871/document
https://hal.sorbonne-universite.fr/hal-02297871/document
Autor:
Kelvine Chignen Possi, Samy Omri, Houda Tahiri, Sylvain Chemtob, Mukandila Mulumba, William D. Lubell, Yésica García-Ramos, Huy Ong
Publikováno v:
Journal of Medicinal Chemistry. 60:9263-9274
Azapeptide analogues of growth hormone releasing peptide-6 (GHRP-6) exhibit promising affinity, selectivity, and modulator activity on the cluster of differentiation 36 receptor (CD36). For example, [A1, azaF4]- and [azaY4]-GHRP-6 (1a and 2b) were pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f291304dd8f6003e640478c2f4576d
https://doi.org/10.1021/acs.jmedchem.7b01209
https://doi.org/10.1021/acs.jmedchem.7b01209
Publikováno v:
Angewandte Chemie. 129:6381-6385
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a967b920115ced273b7e9f86298da64
https://doi.org/10.1002/ange.201611685
https://doi.org/10.1002/ange.201611685
Publikováno v:
Angewandte Chemie International Edition. 56:6284-6288
Macrocyclization has enabled the use of peptides in drug discovery creating a need for methods to synthesize diverse peptide macrocycles. Azapeptides have advanced to clinically used drugs, however, few cyclic azapeptides have been studied. A multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbaaccc2a1a867d990ba0c535198f782
https://doi.org/10.1002/anie.201611685
https://doi.org/10.1002/anie.201611685
Autor:
Sylvain Chemtob, Ahsanullah, Emma Danelius, Mukandila Mulumba, Ragnhild G Ohm, Máté Erdélyi, William D. Lubell, Huy Ong
Publikováno v:
Journal of medicinal chemistry. 62(24)
Dynamic chirality influences numerous processes in nature from protein folding to catalysis. Azapeptides are peptidomimetics possessing semicarbazide residues that can interconvert between sp2 and sp3 hybridization, resulting in stereodynamic interco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3157b080d7500bd786ae5c3a26590487
https://pubmed.ncbi.nlm.nih.gov/31774287
https://pubmed.ncbi.nlm.nih.gov/31774287