Orphan G-protein-coupled receptors: the next generation of drug targets?

Autor: Wilson, Shelagh, Bergsma, Derk J, Chambers, Jon K, Muir, Alison I, Fantom, Kenneth G M, Ellis, Catherine, Murdock, Paul R, Herrity, Nicole C, Stadel, Jeffrey M

The pharmaceutical industry has readily embraced genomics to provide it with new targets for drug discovery. Large scale DNA sequencing has allowed the identification of a plethora of DNA sequences distantly related to known G protein-coupled recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a438f9a29111fcd2f483f987bf5a63e
https://europepmc.org/articles/PMC1565744/

SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): Discovery of antagonist SB-568849

Autor: Witty, David R., Bateson, John H., Hervieu, Guillaume J., Jeffrey, Phillip, Johnson, Christopher N., Muir, Alison I., O’Hanlon, Peter J., Stemp, Geoffrey, Stevens, Alex J., Thewlis, Kevin M., Wilson, Shelagh, Winborn, Kim Y.

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 15 September 2006 16(18):4865-4871

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Neuromedin U Is a Potent Agonist at the Orphan G Protein-coupled Receptor FM3*

Autor: Szekeres, Philip G., Muir, Alison I., Spinage, Lisa D., Miller, Jane E., Butler, Sharon I., Smith, Angela, Rennie, Gillian I., Murdock, Paul R., Fitzgerald, Laura R., Wu, Hsiao-ling, McMillan, Lynette J., Guerrera, Stephanie, Vawter, Lisa, Elshourbagy, Nabil A., Mooney, Jeffrey L., Bergsma, Derk J., Wilson, Shelagh, Chambers, Jon K.

Publikováno v: Journal of Biological Chemistry; July 2000, Vol. 275 Issue: 27 p20247-20250, 4p

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.

Autor: Briscoe CP; Department of Metabolic Diseases, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA. cpb15172@gsk.com, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT, Murdock PR, Sauls HR Jr, Shabon U, Spinage LD, Strum JC, Szekeres PG, Tan KB, Way JM, Ignar DM, Wilson S, Muir AI

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2003 Mar 28; Vol. 278 (13), pp. 11303-11. Date of Electronic Publication: 2002 Dec 19.