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AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons.

Autor: Maltby CJ; Department of Neurology, University of Michigan, Ann Arbor, MI, USA., Krans A; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Ann Arbor Veterans Administration Healthcare, Ann Arbor, MI, USA., Grudzien SJ; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Palacios Y; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Postbaccalaureate Research Education Program, University of Michigan, Ann Arbor, MI, USA., Muiños J; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; UM SMART Undergraduate Summer Program, University of Michigan, Ann Arbor, MI, USA., Suárez A; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Postbaccalaureate Research Education Program, University of Michigan, Ann Arbor, MI, USA., Asher M; Department of Neurology, University of Michigan, Ann Arbor, MI, USA., Khurana V; Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Barmada SJ; Department of Neurology, University of Michigan, Ann Arbor, MI, USA., Dijkstra AA; Department of Pathology, Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands., Todd PK; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Ann Arbor Veterans Administration Healthcare, Ann Arbor, MI, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 14. Date of Electronic Publication: 2023 Dec 14.