Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Muheeb, Beg"'
Autor:
Salil Varshney, Durgesh Kumar, Rakhi Choudhary, Abhishek Gupta, Muheeb Beg, Kripa Shankar, Sujith Rajan, Ankita Srivastava, Sanchita Gupta, Nilesh Khandelwal, Vishal M. Balaramnavar, Anil N. Gaikwad
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117330- (2024)
Repositioning of FDA approved/clinical phase drugs has recently opened a new opportunity for rapid approval of drugs, as it shortens the overall process of drug discovery and development. In previous studies, we predicted the possibility of better ac
Externí odkaz:
https://doaj.org/article/df316dba7871443a9a441418cf2b214d
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/7632aa24143041e5968f6831fbd1a467
Publikováno v:
eLife, Vol 6 (2017)
Insulin, downstream of Akt activation, promotes glucose uptake into fat and muscle cells to lower postprandial blood glucose, an enforced change in cellular metabolism to maintain glucose homeostasis. This effect is mediated by the Glut4 glucose tran
Externí odkaz:
https://doaj.org/article/682f7ad30cc64599b1291312d20a9dd6
Autor:
Salil Varshney, Kripa Shankar, Muheeb Beg, Vishal M. Balaramnavar, Sunil Kumar Mishra, Pankaj Jagdale, Shishir Srivastava, Yashpal S. Chhonker, Vijai Lakshmi, Bhushan P. Chaudhari, Rabi Shankar Bhatta, Anil Kumar Saxena, Anil Nilkanth Gaikwad
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 6, Pp 1019-1032 (2014)
We developed a common feature pharmacophore model using known antiadipogenic compounds (CFPMA). We identified rohitukine, a reported chromone anticancer alkaloid as a potential hit through in silico mapping of the in-house natural product library on
Externí odkaz:
https://doaj.org/article/ea930efdb50a4400851bdf969bc5333a
Publikováno v:
The Journal of Biological Chemistry
Traditionally, lipolysis has been regarded as an enzymatic activity that liberates fatty acids as metabolic fuel. However, recent work has shown that novel substrates, including a variety of lipid compounds such as fatty acids and their derivatives,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843afc812038c7071cb5c29c54353e0a
http://europepmc.org/articles/PMC7949114
http://europepmc.org/articles/PMC7949114
Autor:
Muheeb Beg, Kripa Shankar, Durgesh Kumar, Raj Kumar Mishra, Salil Varshney, Sujith Rajan, Abhishek Gupta, Ankita Srivastava, Sanchita Gupta, Anil N. Gaikwad
Publikováno v:
Journal of Molecular Medicine. 96:315-331
Defect in insulin signaling leads to the development of insulin resistance followed by type 2 diabetes. Exploiting our previously developed physiological chronic hyperinsulinemia (CI)-mediated insulin resistance (IR) model, we wanted to understand ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b59b1bbcc35c58b25bb0fb6597b9de
https://doi.org/10.1007/s00109-018-1623-z
https://doi.org/10.1007/s00109-018-1623-z
Autor:
Ankita Srivastava, Abbas Ali Mahdi, Salil Varshney, Madhu Dikshit, Muheeb Beg, Kalpana Singh, Sujith Rajan, Durgesh Kumar, Kripa Shankar, Abhishek Gupta, Anil N. Gaikwad, Satyendra Kumar Sonkar
Publikováno v:
Free Radical Biology and Medicine. 112:93-108
Leptin, following its discovery, has developed a formidable interest in the scientific community to delineate its contribution towards overall metabolic homeostasis. Contradictory reports have been published on leptin administration effects on whole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8446f910a75c58e1f709af8cca96cbf0
https://doi.org/10.1016/j.freeradbiomed.2017.07.016
https://doi.org/10.1016/j.freeradbiomed.2017.07.016
Autor:
Kripa Shankar, Abhishek Gupta, Durgesh Kumar, Narender Tadigoppula, Sujith Rajan, Anil N. Gaikwad, R. J. Choudhary, Pragya Yadav, Vishal M. Balaramnavar, Rabi Sankar Bhatta, Salil Varshney, Ankita Srivastava, Vinay Kumar Singh, Muheeb Beg, Santosh Kumar
Publikováno v:
Metabolism. 73:109-124
Background Adipocyte dysfunction, obesity and associated metabolic disorders are of prime healthcare concern worldwide. Among available medications, natural products and inspired molecules hold 40% space in clinically prescribed medicines. In queue,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685a0a7c9aca439ada5fa8c40cffdcad
https://doi.org/10.1016/j.metabol.2017.05.005
https://doi.org/10.1016/j.metabol.2017.05.005
Autor:
Durgesh Kumar, Kripa Shankar, Sujith Rajan, Abhishek Gupta, Ankita Srivastava, Anil N. Gaikwad, Muheeb Beg, Salil Varshney
Publikováno v:
Molecular and Cellular Endocrinology. 437:97-107
Insulin resistance is associated with deregulation of insulin signaling owing to the chronic exposure of insulin (hyperinsulinemia) to the tissues. Phosphorylation and dephosphorylation events in insulin signaling pathway play an essential role in si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7689513ff04bac8abb59904549f3ece5
https://doi.org/10.1016/j.mce.2016.08.016
https://doi.org/10.1016/j.mce.2016.08.016
Downregulation of a GPCR by β-Arrestin2-Mediated Switch from an Endosomal to a TGN Recycling Pathway
Publikováno v:
Cell Reports. 17:2966-2978
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in nutrient homeostasis. GIP receptor (GIPR) is constitutively internalized and returned to the plasma membrane, atypical behavior for a G-protein-coupled receptor (GP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f8d2a4d86709db32a75de8d4ae8b26
https://doi.org/10.1016/j.celrep.2016.11.050
https://doi.org/10.1016/j.celrep.2016.11.050