Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models

Autor: Anny Devoy, Georgia Price, Francesca De Giorgio, Rosie Bunton-Stasyshyn, David Thompson, Samanta Gasco, Alasdair Allan, Gemma F. Codner, Remya R. Nair, Charlotte Tibbit, Ross McLeod, Zeinab Ali, Judith Noda, Alessandro Marrero-Gagliardi, José M. Brito-Armas, Muhammet M. Öztürk, Michelle Simon, Edward O’Neill, Sam Bryce-Smith, Jackie Harrison, Gemma Atkins, Silvia Corrochano, Michelle Stewart, Lydia Teboul, Abraham Acevedo-Arozena, Elizabeth M.C. Fisher, Thomas J. Cunningham

Publikováno v: iScience, Vol 25, Iss 4, Pp 103999- (2022)

Externí odkaz: https://doaj.org/article/b6e675c7a1d040dd9354ef6662434d04

TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau

Autor: Muhammet M Öztürk, Bryce L Mashimo, Maria Medalla, Lulu Jiang, Samantha Boudeau, Peter E.A. Ash, Guillermo Socorro, Jenifer Shattuck, Susanne Wegmann, Pavel Ivanov, Yari Carlomagno, Nicholas M. Kanaan, Benjamin Wolozin, Mark Knobel, Leonard Petrucelli, Shuwen Lei, Louloua F A Al-Mohanna

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 118(9), e2014188118-(2021). doi:10.1073/pnas.2014188118

Significance Phase separation of proteins is increasingly thought to play a fundamental role in biological processes. Recent studies show that tau protein phase separates, but the biological significance is unknown since artificial crowding agents ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d0a132fc70ab180f1313204a691274
http://europepmc.org/articles/PMC7936275