Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Muhammad-Al-Mustafa Ismail"'
Autor:
Silvia Maioli, Ann Båvner, Zeina Ali, Maura Heverin, Muhammad-Al-Mustafa Ismail, Elena Puerta, Maria Olin, Ahmed Saeed, Marjan Shafaati, Paolo Parini, Angel Cedazo-Minguez, Ingemar Björkhem
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68534 (2013)
We previously described a heterozygous mouse model overexpressing human HA-tagged 24S-hydroxylase (CYP46A1) utilizing a ubiquitous expression vector. In this study, we generated homozygotes of these mice with circulating levels of 24OH 30-60% higher
Externí odkaz:
https://doaj.org/article/2ff61c800796445390811baa10e7bf25
Autor:
Mariana A Romão, Laura Mateos, Raúl Loera-Valencia, Angel Cedazo-Minguez, Maria Lodeiro, Elena Puerta, Muhammad-Al-Mustafa Ismail, Cláudio M. Gomes, Ingemar Björkhem, Paula Merino-Serrais, Julen Goikolea, Silvia Maioli
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecular Neurobiology
instname
Molecular Neurobiology
Alterations in cholesterol metabolism in the brain have a major role in the physiology of Alzheimer’s disease (AD). Oxysterols are cholesterol metabolites with multiple implications in memory functions and in neurodegeneration. Previous studies hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71650c5e01bc7baeadbbb8562a3b5ca
http://hdl.handle.net/10261/261869
http://hdl.handle.net/10261/261869
Autor:
Nihan Burul-Bozkurt, Inci Kazkayasi, Angel Cedazo-Minguez, Can Pekiner, Muhammad-Al-Mustafa Ismail, Serdar Uma, Paula Merino-Serrais
Publikováno v:
Pharmacological Reports. 70:677-683
Background Many studies have indicated a relationship between diabetes and Alzheimer’s disease (AD). However, the molecular mechanism underlying this association has not been clarified. Among several factors, insulin degrading enzyme (IDE), which p
Publikováno v:
Progress in molecular biology and translational science. 168
Alzheimer's disease (AD) is the major form of dementia and a growing epidemic for which no disease-modifying treatments exist. AD is characterized by the early loss of synapses in the brain and, at later stages, neuronal death accompanied with progre
Autor:
Laura Mateos, Paula Merino-Serrais, Silvia Maioli, Eran Leitersdorf, Muhammad-Al-Mustafa Ismail, Lars Olof-Wahlund, Balázs Gulyás, Zeina Ali, Eric Westman, Maria Lodeiro, Irina Savitcheva, Ingemar Björkhem, Angel Cedazo-Minguez, Bengt Winblad
Publikováno v:
The Journal of Experimental Medicine
Ismail et al. show that 27-hydroxycholesterol, a peripheral cholesterol metabolite capable of passing the blood–brain barrier, reduces brain glucose uptake by upregulating the renin-angiotensin system and inhibiting GLUT4. This alteration affects m
Autor:
Ingemar Björkhem, Angel Cedazo-Minguez, Can Pekiner, Nihan Burul-Bozkurt, Muhammad-Al-Mustafa Ismail, Inci Kazkayasi, Cristina Parrado-Fernandez, Serdar Uma
Publikováno v:
Neuroscience Letters. 633:174-181
Several studies demonstrated that Diabetes mellitus (DM) enhances the risk for Alzheimer's disease (AD). Although hyperglycemia and perturbed function of insulin signaling have been proposed to contribute to AD pathogenesis, the molecular mechanisms
Alzheimer's disease (AD) is the major form of dementia and a growing epidemic for which no disease-modifying treatments exist. AD is characterized by the early loss of synapses in the brain and, at later stages, neuronal death accompanied with progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::620fd9b2adf0a733f36349b4eecd8efe
https://doi.org/10.1016/bs.pmbts.2019.07.003
https://doi.org/10.1016/bs.pmbts.2019.07.003
Autor:
Takaomi C. Saido, Bengt Winblad, Muhammad-Al-Mustafa Ismail, Maria Eriksdotter, A. Piras, Raúl Loera-Valencia, S. Manchanda, Per Nilsson, Jan Johansson, Helga Eyjolfsdottir
Publikováno v:
Journal of internal medicine. 284(1)
Alzheimer's disease (AD) causes dementia in both young and old people affecting more than 40 million people worldwide. The two neuropathological hallmarks of the disease, amyloid beta (Aβ) plaques and neurofibrillary tangles consisting of protein ta
Autor:
Raúl Loera-Valencia, Paula Merino-Serrais, Eva M. Jimenez-Mateos, Eduardo Matute, Patricia Rodriguez-Rodriguez, Silvia Maioli, Cristina Parrado-Fernandez, Muhammad Al Mustafa Ismail, Angel Cedazo-Minguez, Ingemar Björkhem, Javier DeFelipe
Publikováno v:
Cerebral Cortex
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cerebral Cortex (New York, NY)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cerebral Cortex (New York, NY)
Hypercholesterolemia is a risk factor for neurodegenerative diseases, but how high blood cholesterol levels are linked to neurodegeneration is still unknown. Here, we show that an excess of the blood–brain barrier permeable cholesterol metabolite 2
Autor:
Francisco J. Gil-Bea, Bengt Winblad, Valerio Leoni, Angel Cedazo-Minguez, Ingemar Björkhem, Laura Mateos, Muhammad Al Mustafa Ismail
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
instname
In spite of the fact that cholesterol does not pass the blood-brain barrier, hypercholesterolemia has been linked to increase Alzheimer's disease (AD) risk. Hypertension is another risk factor and angiotensin converting enzyme (ACE) activity is known