Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Muhammad Umair, Naseem"'
Autor:
Lauren M. Ashwood, Khaled A. Elnahriry, Zachary K. Stewart, Thomas Shafee, Muhammad Umair Naseem, Tibor G. Szanto, Chloé A. van der Burg, Hayden L. Smith, Joachim M. Surm, Eivind A. B. Undheim, Bruno Madio, Brett R. Hamilton, Shaodong Guo, Dorothy C. C. Wai, Victoria L. Coyne, Matthew J. Phillips, Kevin J. Dudley, David A. Hurwood, Gyorgy Panyi, Glenn F. King, Ana Pavasovic, Raymond S. Norton, Peter J. Prentis
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-25 (2023)
Abstract Background The ShK toxin from Stichodactyla helianthus has established the therapeutic potential of sea anemone venom peptides, but many lineage-specific toxin families in Actiniarians remain uncharacterised. One such peptide family, sea ane
Externí odkaz:
https://doaj.org/article/21a4debffec04564ae9a29b4a8776746
Autor:
Rosevalentine Bosire, Lina Fadel, Gábor Mocsár, Péter Nánási, Pialy Sen, Anshu Kumar Sharma, Muhammad Umair Naseem, Attila Kovács, Jennifer Kugel, Guido Kroemer, György Vámosi, Gábor Szabó
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Doxorubicin (Dox), a widely used anticancer DNA-binding drug, affects chromatin in multiple ways, and these effects contribute to both its efficacy and its dose-limiting side effects, especially cardiotoxicity. Here, we studied the effects o
Externí odkaz:
https://doaj.org/article/b00b0ea5320248cebb175443b8936ee0
Autor:
Kashmala Shakeel, Timoteo Olamendi-Portugal, Muhammad Umair Naseem, Baltazar Becerril, Fernando Z. Zamudio, Gustavo Delgado-Prudencio, Lourival Domingos Possani, Gyorgy Panyi
Publikováno v:
Toxins, Vol 15, Iss 8, p 506 (2023)
Seven new peptides denominated CboK1 to CboK7 were isolated from the venom of the Mexican scorpion Centruroides bonito and their primary structures were determined. The molecular weights ranged between 3760.4 Da and 4357.9 Da, containing 32 to 39 ami
Externí odkaz:
https://doaj.org/article/0af01c9f57f1419fadadf2a3bd4fdaed
Autor:
Muhammad Umair Naseem, Georgina Gurrola-Briones, Margarita R. Romero-Imbachi, Jesus Borrego, Edson Carcamo-Noriega, José Beltrán-Vidal, Fernando Z. Zamudio, Kashmala Shakeel, Lourival Domingos Possani, Gyorgy Panyi
Publikováno v:
Toxins, Vol 15, Iss 1, p 41 (2023)
A novel peptide, Cm39, was identified in the venom of the scorpion Centruroides margaritatus. Its primary structure was determined. It consists of 37 amino acid residues with a MW of 3980.2 Da. The full chemical synthesis and proper folding of Cm39 w
Externí odkaz:
https://doaj.org/article/67ed73345b9a4bbebdcd2538b18b25d0
Autor:
Jesús Borrego, Muhammad Umair Naseem, Al Nasar Ahmed Sehgal, Lipsa Rani Panda, Kashmala Shakeel, Attila Gaspar, Cynthia Nagy, Zoltan Varga, Gyorgy Panyi
Publikováno v:
Journal of Fungi, Vol 8, Iss 11, p 1215 (2022)
The Kv1.3 channel has become a therapeutic target for the treatment of various diseases. Several Kv1.3 channel blockers have been characterized from scorpion venom; however, extensive studies require amounts of toxin that cannot be readily obtained d
Externí odkaz:
https://doaj.org/article/e66c946cc5fc41abb7997fb4015c7f54
Autor:
Muhammad Umair Naseem, Gabor Tajti, Attila Gaspar, Tibor G. Szanto, Jesús Borrego, Gyorgy Panyi
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Margatoxin (MgTx) is a high-affinity blocker of voltage-gated potassium (Kv) channels. It inhibits Kv1.1–Kv1.3 ion channels in picomolar concentrations. This toxin is widely used to study physiological function of Kv ion channels in various cell ty
Externí odkaz:
https://doaj.org/article/b4c80743087e4d37a5242da8909296c6
Publikováno v:
Advancements in Life Sciences, Vol 6, Iss 2, Pp 81-87 (2019)
Background: Enhanced production and improved properties of cellulases for a greater activity on plant biomass would rank amongst the top priorities for second-generation ethanol production. Based on the emergence of protein engineering as a cutting-e
Externí odkaz:
https://doaj.org/article/1d13c1e57f004fa19f3ff2a2288680e2
A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel KV1.3
Autor:
Dorothy C. C. Wai, Muhammad Umair Naseem, Gábor Mocsár, Sanjeevini Babu Reddiar, Yijun Pan, Agota Csoti, Peter Hajdu, Cameron Nowell, Joseph A. Nicolazzo, Gyorgy Panyi, Raymond S. Norton
Publikováno v:
Bioconjugate Chemistry. 33:2197-2212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74356c1c18033396c070e24d36dcd079
https://doi.org/10.1021/acs.bioconjchem.2c00436
https://doi.org/10.1021/acs.bioconjchem.2c00436
The Voltage-Gated Hv1 H+ Channel Is Expressed in Tumor-Infiltrating Myeloid-Derived Suppressor Cells
Autor:
Marco Cozzolino, Adrienn Gyöngyösi, Eva Korpos, Peter Gogolak, Muhammad Umair Naseem, Judit Kállai, Arpad Lanyi, Gyorgy Panyi
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 7; Pages: 6216
Myeloid-derived suppressor cells (MDSCs) are key determinants of the immunosuppressive microenvironment in tumors. As ion channels play key roles in the physiology/pathophysiology of immune cells, we aimed at studying the ion channel repertoire in tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9823bf0c4cea6631f298a306203b8e
Autor:
Lauren M. Ashwood, Khaled A. Elnahriry, Zachary K. Stewart, Thomas Shafee, Muhammad Umair Naseem, Tibor G. Szanto, Chloé A. van der Burg, Hayden L. Smith, Joachim M. Surm, Eivind A.B. Undheim, Bruno Madio, Brett R. Hamilton, Shaodong Guo, Dorothy C.C. Wai, Victoria L. Coyne, Matthew J. Phillips, Kevin J. Dudley, David A. Hurwood, Gyorgy Panyi, Glenn F. King, Ana Pavasovic, Raymond S. Norton, Peter J. Prentis
ShK fromStichodactyla helianthushas established the therapeutic potential of sea anemone venom peptides, but many lineage-specific toxin families in actinarians remain uncharacterised. One such peptide family, sea anemone 8 (SA8), is present in all f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65099c4077a6d6a842da8bc1eb44862b
https://doi.org/10.1101/2022.12.08.518931
https://doi.org/10.1101/2022.12.08.518931
