ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning

Autor: Gabriela D'Amico, Isabelle Fernandez, Jesús Gómez-Escudero, Hyojin Kim, Eleni Maniati, Muhammad Syahmi Azman, Faraz K. Mardakheh, Bryan Serrels, Alan Serrels, Maddy Parsons, Anthony Squire, Graeme M. Birdsey, Anna M. Randi, Alfonso Bolado-Carrancio, Rathi Gangeswaran, Louise E. Reynolds, Natalia Bodrug, Yaohe Wang, Jun Wang, Pascal Meier, Kairbaan M. Hodivala-Dilke

Publikováno v: D'amico, G, Fernandez, I, Gómez-escudero, J, Kim, H, Maniati, E, Azman, M S, Mardakheh, F K, Serrels, B, Serrels, A, Parsons, M, Squire, A, Birdsey, G M, Randi, A M, Bolado-carrancio, A, Gangeswaran, R, Reynolds, L E, Bodrug, N, Wang, Y, Wang, J, Meier, P & Hodivala-dilke, K M 2022, ' ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning ', Development, vol. 149, no. 13, dev200528 . https://doi.org/10.1242/dev.200528

Precise vascular patterning is crucial for normal growth and development. The ERG transcription factor drives Delta-like ligand 4 (DLL4)/Notch signalling and is thought to act as a pivotal regulator of endothelial cell (EC) dynamics and developmental

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