Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Muhammad Murtaza Hassan"'
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 6, Pp 732-737 (2019)
The crystal structures of an intermediate, C10H9ClN4O, 3-[(6-chloro-7H-purin-7-yl)methyl]cyclobutan-1-one (I), and two N-7 and N-9 regioisomeric oxetanocin nucleoside analogs, C10H13ClN4O, 3-[(6-chloro-8,9-dihydro-7H-purin-7-yl)methyl]cyclobutan-1-ol
Externí odkaz:
https://doaj.org/article/5a7811ee3ca94a4c9da7851a2c79aef9
Publikováno v:
Molecules, Vol 25, Iss 10, p 2285 (2020)
The use of light-activated chemical probes to study biological interactions was first discovered in the 1960s, and has since found many applications in studying diseases and gaining deeper insight into various cellular mechanisms involving protein–
Externí odkaz:
https://doaj.org/article/01fb0a8716a645f5a596bcada297932d
Autor:
Noha Hasaneen, Abdelaziz Ebead, Muhammad Murtaza Hassan, Hanan Afifi, Howard Hunter, Edward Lee-Ruff, Nadia S. El-Gohary, Azza R. Maarouf, Ali A. El-Emam
Publikováno v:
Molecules, Vol 24, Iss 18, p 3235 (2019)
The coupling of 2-bromo-3-benzoyloxycyclobutanone with purine under basic conditions produces two regioisomers consisting of the N-7 and N-9 alkylated products in equal amounts in their racemic forms. The distribution of the isomers is consistent wit
Externí odkaz:
https://doaj.org/article/4ff8ef9eff684a418eed543c88299e63
Autor:
Nabanita Nawar, Shazreh Bukhari, Ashley A. Adile, Yujin Suk, Pimyupa Manaswiyoungkul, Krimo Toutah, Olasunkanmi O. Olaoye, Yasir S. Raouf, Abootaleb Sedighi, Harsimran Kaur Garcha, Muhammad Murtaza Hassan, William Gwynne, Johan Israelian, Tudor B. Radu, Mulu Geletu, Ayah Abdeldayem, Justyna M. Gawel, Aaron D. Cabral, Chitra Venugopal, Elvin D. de Araujo, Sheila K. Singh, Patrick T. Gunning
Publikováno v:
Journal of Medicinal Chemistry. 65:3193-3217
Autor:
Muhammad Murtaza Hassan, Abootaleb Sedighi, Olasunkanmi O. Olaoye, Cécile Häberli, Annika Merz, Elizabeth Ramos‐Morales, Elvin D. de Araujo, Christophe Romier, Manfred Jung, Jennifer Keiser, Patrick T. Gunning
Publikováno v:
ChemMedChem. 17(18)
Schistosomiasis is a prevalent yet neglected tropical parasitic disease caused by the Schistosoma genus of blood flukes. Praziquantel is the only currently available treatment, hence drug resistance poses a major threat. Recently, histone deacetylase
Autor:
Yen-Der Li, Michelle W. Ma, Muhammad Murtaza Hassan, Kedar Puvar, Mingxing Teng, Brittany Sandoval, Ryan Lumpkin, Scott B. Ficarro, Michelle Y. Wang, Shawn Xu, Brian J. Groendyke, Logan H. Sigua, Isidoro Tavares, Charles Zou, Jonathan M. Tsai, Paul M. Park, Hojong Yoon, Radosław P. Nowak, Jarrod A. Marto, Jun Qi, Katherine A. Donovan, Mikołaj Słabicki, Nathanael S. Gray, Eric S. Fischer, Benjamin L. Ebert
Publikováno v:
Cancer Research. 83:3424-3424
Molecular glue degraders have emerged as a powerful class of small-molecule therapeutics, as demonstrated by the clinical successes of thalidomide analogs in the treatment of hematological malignancies. These small molecules act by recruiting ubiquit
Publikováno v:
Acta Crystallographica Section E Crystallographic Communications. 75:732-737
The crystal structures of an intermediate, C10H9ClN4O, 3-[(6-chloro-7H-purin-7-yl)methyl]cyclobutan-1-one (I), and two N-7 and N-9 regioisomeric oxetanocin nucleoside analogs, C10H13ClN4O, 3-[(6-chloro-8,9-dihydro-7H-purin-7-yl)methyl]cyclobutan-1-ol
Autor:
Andrew E. Shouksmith, Abootaleb Sedighi, Yasir S. Raouf, Niyati Kachhiyapatel, Ayah Abdeldayem, Paris R. Watson, Krimo Toutah, Olasunkanmi O. Olaoye, David W. Christianson, Patrick T. Gunning, Shazreh Bukhari, Pimyupa Manaswiyoungkul, Justyna M. Gawel, Aaron D. Cabral, Johan Israelian, Muhammad Murtaza Hassan, Nabanita Nawar, Fettah Erdogan, Elvin D. de Araujo, Tudor B. Radu, Mulu Geletu
Publikováno v:
J Med Chem
Histone deacetylase 6 (HDAC6) is involved in multiple regulatory processes, ranging from cellular stress to intracellular transport. Inhibition of aberrant HDAC6 activity in several cancers and neurological diseases has been shown to be efficacious i
Autor:
Patrick T. Gunning, Yasir S. Raouf, Muhammad Murtaza Hassan, Jana von Jan, Aleksandr Ianevski, Muzaffar N. Bhatti, Justyna M. Gawel, Mulu Geletu, Pimyupa Manaswiyoungkul, Nabanita Nawar, Elvin D. de Araujo, Helena Sorger, Olasunkanmi O. Olaoye, Tero Aittokallio, Oliver H. Krämer, Marco Herling, Sanna Timonen, Ayah Abdeldayem, Krimo Toutah, Tudor B. Radu, Richard Moriggl, Shazreh Bukhari, Johan Israelian, Heidi A. Neubauer, Satu Mustjoki, Andrew E. Shouksmith, Abootaleb Sedighi
Publikováno v:
Journal of Medicinal Chemistry
Epigenetic targeting has emerged as an efficacious therapy for hematological cancers. The rare and incurable T-cell prolymphocytic leukemia (T-PLL) is known for its aggressive clinical course. Current epigenetic agents such as histone deacetylase (HD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3a89d15e76dd9bd052d4a50193efb2
http://hdl.handle.net/10852/93204
http://hdl.handle.net/10852/93204
Autor:
Muhammad Murtaza Hassan, Yasir S. Raouf, Pimyupa Manaswiyoungkul, Aaron D. Cabral, Abootaleb Sedighi, Rabia Altintas, Fettah Erdogan, Patrick T. Gunning, Giovanni Ganda, David W.J. Armstrong, Olasunkanmi O. Olaoye, Elvin D. de Araujo, Johan Israelian, Fabrizio Angeles, Nabanita Nawar
Publikováno v:
Journal of medicinal chemistry. 63(15)
Histone deacetylases (HDACs) are an attractive therapeutic target for a variety of human diseases. Currently, all four FDA-approved HDAC-targeting drugs are nonselective, pan-HDAC inhibitors, exhibiting adverse side effects at therapeutic doses. Alth