Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Muhammad M. Khalifa"'
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Diastereoselective, Multicomponent Synthesis of Pyrrolopyrazinoquinazolinones via a Tandem Quinazolinone Rearrangement/Intramolecular Ring Closure of Tautomeric (Z)-Benzamidines
Autor: Victor A. Jaffett, Muhammad M. Khalifa, Ilia A. Guzei, Jhewelle N. Fitz-Henley, Jennifer E. Golden
Publikováno v: Org Lett
An expedient route to enantiopure, diastereomeric pyrrolopyrazinoquinazolinones was developed following the discovery of a domino quinazolinone rearrangement-intramolecular cyclization of N-H benzamidines. A Ugi-Mumm-Staudinger sequence employing an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d804f87ce548064b7cff76d631b29a
https://doi.org/10.1021/acs.orglett.1c01955
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2
Characterization of Glucokinases from Pathogenic Free-Living Amoebae
Autor: Jillian E. Milanes, Jimmy Suryadi, Neil P. Monaghan, Elijah M. Harding, Corbin S. Morris, Soren D. Rozema, Muhammad M. Khalifa, Jennifer E. Golden, Isabelle Q. Phan, Rachael Zigweid, Jan Abendroth, Christopher A. Rice, Hayden T. McCord, Stevin Wilson, Michael K. Fenwick, James C. Morris
Publikováno v: Antimicrob Agents Chemother
Infection with pathogenic free-living amoebae, including Naegleria fowleri, Acanthamoeba spp., and Balamuthia mandrillaris, can lead to life-threatening illnesses, primarily because of catastrophic central nervous system involvement. Efficacious trea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e07507698ac61ce58ce4a37e32ebead
https://doi.org/10.1128/aac.02373-21
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3
Dual-Stage Picolinic Acid-Derived Inhibitors of Toxoplasma gondii
Autor: Muhammad M. Khalifa, Jennifer E. Golden, Neil P Monaghan, Gina M Gallego-Lopez, Bruno Martorelli Di Genova, Laura J. Knoll, Soren D. Rozema, James Morris, Sarah G McAlpine, David M. Stevenson
Publikováno v: ACS Med Chem Lett
[Image: see text] Toxoplasma gondii causes a prevalent human infection for which only the acute stage has an FDA-approved therapy. To find inhibitors of both the acute stage parasites and the persistent cyst stage that causes a chronic infection, we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9bdad1062667b4ad10c2072501d96f
https://doi.org/10.1021/acsmedchemlett.0c00267
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4
Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using pKa-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam
Autor: Muhammad M. Khalifa, Jennifer E. Golden, Satish Chandra Philkhana
Publikováno v: The Journal of Organic Chemistry. 85:464-481
An anionic annulation strategy employing isatoic anhydrides and a wide assortment of enolizable partners was developed to afford over 80 novel ring-fused, N-substituted 4-quinolinones, an underrepresented privileged template. Multiple factors governi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d1aaa33b84e77eb51b5de1b5fda97f2
https://doi.org/10.1021/acs.joc.9b02541
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5
Seeking career clarity
Autor: Yongsheng Ji, Athanasia Nikolaou, Pragya Srivastava, Khor Waiho, Samuel Nathan Kirshner, Brynn Anne Hollingsworth, Michael J. Strong, Muhammad M. Khalifa, Aaron Christensen-Quick, Antarip Halder, Aleksandra Kosanic, Nikos Konstantinides, Norman van Rhijn, Katie Burnette, Ashley B. Heim, Chloe Antoniou, Eric Britt Moore, Monika Lewinska, Saumya Saurabh
Publikováno v: Van Rhijn, N, Antoniou, C, Burnette, K, Christensen-Quick, A, Lewinska, M, Ji, Y, Khalifa, M, Nikolaou, A, Srivastava, P, Hollingsworth, B, Sarah, S, Konstantinides, N, Heim, A, Moore, E, Strong, M, Kosanic, A, Kirshner, S, Halder, A & Wait, K 2020, ' Seeking career clarity ', Science, vol. 368, no. 6486, 10.1126/science.abb6859, pp. 26-28 . https://doi.org/10.1126/science.abb6859
We asked young scientists to serve as peer mentors for “Seeking Career Clarity,” the author of the question below. By asking refl ective questions, sharing relevant personal experiences, and of ering advice, these scientists provide support and p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b3c5bfa505787e6b151e0e199495a7
https://doi.org/10.1126/science.abb6859
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6
Enzymatic and Structural Characterization of the Naegleria fowleri Glucokinase
Autor: Stephen L. Patrick, Kayleigh F. Barrett, Wesley C. Van Voorhis, Muhammad M. Khalifa, James Morris, Soren D. Rozema, Isabelle Q. Phan, Jimmy Suryadi, Jan Abendroth, Jennifer E. Golden, Jillian E. Milanes, David M. Dranow
Publikováno v: Antimicrobial Agents and Chemotherapy. 63
Infection with the free-living amoeba Naegleria fowleri leads to life-threatening primary amoebic meningoencephalitis. Efficacious treatment options for these infections are limited and the mortality rate is very high (~98%). Parasite metabolism may
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d39dfe850d374519122effd21748fe
https://doi.org/10.1128/aac.02410-18
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7
Facile Synthesis and Properties of 2‐λ 5 ‐Phosphaquinolines and 2‐λ 5 ‐Phosphaquinolin‐2‐ones
Autor: Muhammad M. Khalifa, Airlia M. Shonkwiler, Darren W. Johnson, Chris L. Vonnegut, Lev N. Zakharov, Michael M. Haley
Publikováno v: Angewandte Chemie. 127:13516-13520
Treatment of 2-ethynylanilines with P(OPh)3 gives either 2,2-diphenoxy-2-λ5-phosphaquinolines or 2-phenoxy-2-λ5-phospha-quinolin-2-ones under transition metal-free conditions. This reaction offers unparalleled access to an underexplored heterocycle
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f184d278655225b007948f331abb33e
https://doi.org/10.1002/ange.201507696
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8
Synthesis of N -substituted aryl amidines by strong base activation of amines
Autor: Michael M. Haley, Micah J. Bodner, J. Andrew Berglund, Muhammad M. Khalifa
Publikováno v: Tetrahedron Letters. 56:4109-4111
We describe an efficient method for the direct preparation of N-substituted aryl amidines from nitriles and primary amines. The protocol employs activation of amines by a strong base and provides greater access to a pharmaceutically relevant function
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0d3649a01441fdc4c4be980fe6885e6
https://doi.org/10.1016/j.tetlet.2015.05.029
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10
ChemInform Abstract: Synthesis of N-Substituted Aryl Amidines by Strong Base Activation of Amines
Autor: J. Andrew Berglund, Muhammad M. Khalifa, Micah J. Bodner, Michael M. Haley
Publikováno v: ChemInform. 46
We describe an efficient method for the direct preparation of N-substituted aryl amidines from nitriles and primary amines. The protocol employs activation of amines by a strong base and provides greater access to a pharmaceutically relevant function
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08c8b17feaa96a2a29bede64bcb6054f
https://doi.org/10.1002/chin.201541093
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