Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Muhammad Imran Sajid"'
Autor:
Muhammad Imran Sajid, Francisco J. Nunez, Farideh Amirrad, Moom Rahman Roosan, Tom Vojtko, Scott McCulloch, Amal Alachkar, Surya M. Nauli
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Chronic hypoxia may have a huge impact on the cardiovascular and renal systems. Advancements in microscopy, metabolomics, and bioinformatics provide opportunities to identify new biomarkers. In this study, we aimed at elucidating the metabol
Externí odkaz:
https://doaj.org/article/05da8bb9b7964d92ad276c1e1ef734ed
Autor:
Mrigank Shekhar Rai, Muhammad Imran Sajid, Jonathan Moreno, Keykavous Parang, Rakesh Kumar Tiwari
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1083 (2024)
Delivering nucleic acid therapeutics across cell membranes is a significant challenge. Cell-penetrating peptides (CPPs) containing arginine (R), tryptophan (W), and histidine (H) show promise for siRNA delivery. To improve siRNA delivery and silence
Externí odkaz:
https://doaj.org/article/883e7669434d412c93e676034f3b8a6f
Autor:
Dindyal Mandal, Sandeep Lohan, Muhammad Imran Sajid, Abdulelah Alhazza, Rakesh Kumar Tiwari, Keykavous Parang, Hamidreza Montazeri Aliabadi
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 666 (2023)
RNA interference (RNAi) has drawn enormous attention as a powerful tool because of its capability to interfere with mRNA and protein production. However, designing a safe and efficient delivery system in RNAi therapeutics remains challenging. Herein,
Externí odkaz:
https://doaj.org/article/6de5c9c6d64c4931b76d760c61570254
Oleyl Conjugated Histidine-Arginine Cell-Penetrating Peptides as Promising Agents for siRNA Delivery
Autor:
Muhammad Imran Sajid, Dindyal Mandal, Naglaa Salem El-Sayed, Sandeep Lohan, Jonathan Moreno, Rakesh Kumar Tiwari
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 881 (2022)
Recent approvals of siRNA-based products motivated the scientific community to explore siRNA as a treatment option for several intractable ailments, especially cancer. The success of approved siRNA therapy requires a suitable and safer drug delivery
Externí odkaz:
https://doaj.org/article/5e1844f9f21a45daaa9b04338aeda2aa
Publikováno v:
Antibiotics, Vol 11, Iss 3, p 416 (2022)
Bacterial resistance is a growing global concern necessitating the discovery and development of antibiotics effective against the drug-resistant bacterial strain. Previously, we reported a cyclic antimicrobial peptide [R4W4] containing arginine (R) a
Externí odkaz:
https://doaj.org/article/45483eed40a14b7189ac3a63ef9603db
Autor:
Amir Nasrolahi Shirazi, Muhammad Imran Sajid, Dindyal Mandal, David Stickley, Stephanie Nagasawa, Joshua Long, Sandeep Lohan, Keykavous Parang, Rakesh Kumar Tiwari
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1064 (2021)
We have recently reported that a cyclic peptide containing five tryptophan, five arginine, and one cysteine amino acids [(WR)5C], was able to produce peptide-capped gadolinium nanoparticles, [(WR)5C]-GdNPs, in the range of 240 to 260 nm upon mixing w
Externí odkaz:
https://doaj.org/article/f0c31434eaa74df2841197714ee41963
Publikováno v:
Pharmaceuticals, Vol 13, Iss 10, p 294 (2020)
The RNA interference (RNAi) pathway possesses immense potential in silencing any gene in human cells. Small interfering RNA (siRNA) can efficiently trigger RNAi silencing of specific genes. FDA Approval of siRNA therapeutics in recent years garnered
Externí odkaz:
https://doaj.org/article/d8dba844482e40318f84438abc599c1d
Autor:
Amir Nasrolahi Shirazi, Shang Eun Park, Shirin Rad, Luiza Baloyan, Dindyal Mandal, Muhammad Imran Sajid, Ryley Hall, Sandeep Lohan, Khalid Zoghebi, Keykavous Parang, Rakesh Kumar Tiwari
Publikováno v:
Pharmaceutics, Vol 12, Iss 9, p 792 (2020)
A cyclic peptide containing one cysteine and five alternating tryptophan and arginine amino acids [(WR)5C] was synthesized using Fmoc/tBu solid-phase methodology. The ability of the synthesized cyclic peptide to produce gadolinium nanoparticles throu
Externí odkaz:
https://doaj.org/article/9ab1a5d0e6ec459f8de2689aac5dd26e
Autor:
Naglaa Salem El-Sayed, Amir Nasrolahi Shirazi, Muhammad Imran Sajid, Shang Eun Park, Keykavous Parang, Rakesh Kumar Tiwari
Publikováno v:
Molecules, Vol 24, Iss 7, p 1427 (2019)
Cell-penetrating peptide [WR]5 has been previously shown to be an efficient molecular transporter for various hydrophilic and hydrophobic molecules. The peptide was synthesized using Fmoc/tBu solid-phase chemistry, and one arginine was replaced with
Externí odkaz:
https://doaj.org/article/2c319f59c1064ac2b61bf1d29e4c8bf4
Autor:
Sorour Khayyatnejad Shoushtari, Keykavous Parang, Rakesh Tiwari, Khalid Zoghebi, Muhammad Imran Sajid
Publikováno v:
Molecular Pharmaceutics. 18:3909-3919
The cell membrane properties create a significant obstacle in intracellular delivery of cell-impermeable and negatively charged molecules. Herein, we report the synthesis and biological evaluation of a novel series of hybrid cyclic-linear peptides co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6745f9a49ec0131ed36012fc8547dd2e
https://doi.org/10.1021/acs.molpharmaceut.1c00594
https://doi.org/10.1021/acs.molpharmaceut.1c00594