Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Muhammad B. Ekram"'
Autor:
Bojana Jovanović, Daniel Temko, Laura E. Stevens, Marco Seehawer, Anne Fassl, Katherine Murphy, Jayati Anand, Kodie Garza, Anushree Gulvady, Xintao Qiu, Nicholas W. Harper, Veerle W. Daniels, Huang Xiao-Yun, Jennifer Y. Ge, Maša Alečković, Jason Pyrdol, Kunihiko Hinohara, Shawn B. Egri, Malvina Papanastasiou, Raga Vadhi, Alba Font-Tello, Robert Witwicki, Guillermo Peluffo, Anne Trinh, Shaokun Shu, Benedetto Diciaccio, Muhammad B. Ekram, Ashim Subedee, Zachary T. Herbert, Kai W. Wucherpfennig, Anthony G. Letai, Jacob D. Jaffe, Piotr Sicinski, Myles Brown, Deborah Dillon, Henry W. Long, Franziska Michor, Kornelia Polyak
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113564- (2023)
Summary: Triple-negative breast cancer (TNBC) is a heterogeneous disease with limited treatment options. To characterize TNBC heterogeneity, we defined transcriptional, epigenetic, and metabolic subtypes and subtype-driving super-enhancers and transc
Externí odkaz:
https://doaj.org/article/5b7a46fb42fa443eac6a172b0b60048f
Publikováno v:
Genomics Data, Vol 3, Iss C, Pp 87-89 (2015)
DNA methylation is a major epigenetic mark associated with multiple aspects of retrotransposons within the mammalian genome. In order to study DNA methylation of a large number of retrotransposons on an individual-locus basis, we have developed a new
Externí odkaz:
https://doaj.org/article/b9518fdb54924f0dafd6c746fd046512
Autor:
Joomyeong Kim, Wesley D. Frey, Hongzhi He, Hana Kim, Muhammad B. Ekram, Arundhati Bakshi, Mohammad Faisal, Bambarendage P. U. Perera, An Ye, Ryoichi Teruyama
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/56b6d49e20234687bd34f1c0b4e71d2e
Autor:
Kornelia Polyak, Franziska Michor, So Yeon Park, Joon Jeong, D. Craig Allred, Kristie Bobolis, Rong Fan, Judy E. Garber, Lisa M. Coussens, Therese Sorlie, Deborah Dillon, Gordon J. Freeman, Ron Rowberry, Jon Wagner, Charles H. McDonnell, Elizabeth Min Hui Kim, Kirsten Babski, Andrea L. Richardson, Hege G. Russnes, Lina Ding, Ying Su, Helga Bergholtz, Minsuk Kwak, Xiaoyuan Zi, Francisco Beca, Lin L. Liu, Anne Trinh, Muhammad B. Ekram, Sung Jin Huh, Carlos R. Gil Del Alcazar
Supplementary Figure S1. Leukocyte frequencies in breast tissues. Supplementary Figure S2. Genes expressed in T cells. Supplementary Figure S3. Activity status of T cells. Supplementary Figure S4. TCR clonotypes in breast tissues. Supplementary Figur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4dbf5a64431466b58c0e00a5b286dd
https://doi.org/10.1158/2159-8290.22531790
https://doi.org/10.1158/2159-8290.22531790
Autor:
Kornelia Polyak, Franziska Michor, So Yeon Park, Joon Jeong, D. Craig Allred, Kristie Bobolis, Rong Fan, Judy E. Garber, Lisa M. Coussens, Therese Sorlie, Deborah Dillon, Gordon J. Freeman, Ron Rowberry, Jon Wagner, Charles H. McDonnell, Elizabeth Min Hui Kim, Kirsten Babski, Andrea L. Richardson, Hege G. Russnes, Lina Ding, Ying Su, Helga Bergholtz, Minsuk Kwak, Xiaoyuan Zi, Francisco Beca, Lin L. Liu, Anne Trinh, Muhammad B. Ekram, Sung Jin Huh, Carlos R. Gil Del Alcazar
Supplementary Table S1. List of tissue samples used. Supplementary Table S2. Raw FACS data in each sample. Supplementary Table S3. List of differentially expressed genes. Supplementary Table S4. Results of GSEA analyses. Supplementary Table S5. Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8019566157c56da010a1fc1ade4031e9
https://doi.org/10.1158/2159-8290.22531784
https://doi.org/10.1158/2159-8290.22531784
Autor:
Housheng H. He, Changmeng Cai, Amina Zoubeidi, Anthony M. Joshua, Felix Y. Feng, Cheryl H. Arrowsmith, Paul C. Boutros, Theodorus van der Kwast, Dianne Chadwick, R. Jeffrey Karnes, Nicholas Erho, Mandeep Takhar, Elai Davicioni, Brian Li, Muhammad B. Ekram, Jens Langstein, Wanting Han, Christine Poon, Catherine Lu, Shuai Gao, Junjie T. Hua, Fraser Soares, Haiyang Guo, Musaddeque Ahmed, Yi Liang
Androgen receptor (AR) signaling is a key driver of prostate cancer, and androgen-deprivation therapy (ADT) is a standard treatment for patients with advanced and metastatic disease. However, patients receiving ADT eventually develop incurable castra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4381a8eef0720dee68e2a3cbe3d8abd0
https://doi.org/10.1158/0008-5472.c.6508953.v1
https://doi.org/10.1158/0008-5472.c.6508953.v1
Autor:
Housheng H. He, Changmeng Cai, Amina Zoubeidi, Anthony M. Joshua, Felix Y. Feng, Cheryl H. Arrowsmith, Paul C. Boutros, Theodorus van der Kwast, Dianne Chadwick, R. Jeffrey Karnes, Nicholas Erho, Mandeep Takhar, Elai Davicioni, Brian Li, Muhammad B. Ekram, Jens Langstein, Wanting Han, Christine Poon, Catherine Lu, Shuai Gao, Junjie T. Hua, Fraser Soares, Haiyang Guo, Musaddeque Ahmed, Yi Liang
Table S1: Primers and siRNA sequences used in this study. Table S2-9: GO analysis of LSD1 and CENPE target genes in LNCaP and abl Cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f46ffbc214f9b3c594e55a1ccf638b
https://doi.org/10.1158/0008-5472.22414344.v1
https://doi.org/10.1158/0008-5472.22414344.v1
Autor:
Housheng H. He, Changmeng Cai, Amina Zoubeidi, Anthony M. Joshua, Felix Y. Feng, Cheryl H. Arrowsmith, Paul C. Boutros, Theodorus van der Kwast, Dianne Chadwick, R. Jeffrey Karnes, Nicholas Erho, Mandeep Takhar, Elai Davicioni, Brian Li, Muhammad B. Ekram, Jens Langstein, Wanting Han, Christine Poon, Catherine Lu, Shuai Gao, Junjie T. Hua, Fraser Soares, Haiyang Guo, Musaddeque Ahmed, Yi Liang
Figures S1-2: LSD1 reprogramming in CRPC. Figure S3: Clinical relevance of CENPE in CRPC. Figures S4-8: Regulation and Function of CENPE in CRPC. Figure S9: Inhibition of CENPE in xenograft model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c94cb8958d84f7151f28ba1ec28d72
https://doi.org/10.1158/0008-5472.22414347.v1
https://doi.org/10.1158/0008-5472.22414347.v1
Autor:
Maša Alečković, Minsuk Kwak, Andriy Marusyk, Muhammad B. Ekram, Tyler Laszewski, Franziska Michor, Natalie L. Kingston, Kimiyo N. Yamamoto, Nikhil Wagle, Rong Fan, Adrienne M. Luoma, Kornelia Polyak, Yuanbo Qin, Nicholas W. Harper, Carlos R. Gil Del Alcazar, Simona Cristea, Michalina Janiszewska, Kai W. Wucherpfennig, Zafira Castaño, Katherine Murphy, Sandra S. McAllister, Ofir Cohen, Shaokun Shu, Doris P. Tabassum
Publikováno v:
Nature cell biology
Most human tumours are heterogeneous, composed of cellular clones with different properties present at variable frequencies. Highly heterogeneous tumours have poor clinical outcomes, yet the underlying mechanism remains poorly understood. Here, we sh
Autor:
Muhammad B Ekram, Joomyeong Kim
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101683 (2014)
In vertebrates, DNA methylation-mediated repression of retrotransposons is essential for the maintenance of genomic integrity. In the current study, we developed a technique termed HT-TREBS (High-Throughput Targeted Repeat Element Bisulfite Sequencin
Externí odkaz:
https://doaj.org/article/267a77c762fa461ebf8bda1ee5da74e0