Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Muhammad Alhawagri"'
Publikováno v:
Journal of Orthopaedic Research. 30:554-560
PMMA particles released from bone implants are considered major contributor to osteolysis and subsequent implant failure. Although the ensuing inflammatory response has been described, the mechanisms underlying PMMA particulate-induced osteolysis rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09c58315b93f7038c18e043d57dc45b2
https://doi.org/10.1002/jor.21555
https://doi.org/10.1002/jor.21555
Publikováno v:
Journal of Bone and Mineral Research
Monocytes differentiate into osteoclasts through stimulation of receptor activator of NF-κB (RANK). Many downstream effectors of RANK play a positive role in osteoclastogenesis, but their relative importance in osteoclast differentiation is unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e452619b344e22a6266b6fdb6cea2ae7
https://doi.org/10.1002/jbmr.4
https://doi.org/10.1002/jbmr.4
Autor:
Roberta Faccio, Julie O'Neal, Benedicte Sammut, Trevor Johnson, Imani Anwisye, Wei Zou, Angela C. Hirbe, Sergio Vaira, Deborah V. Novack, Muhammad Alhawagri, Katherine N. Weilbaecher
Publikováno v:
Proceedings of the National Academy of Sciences. 105:3897-3902
NF-κB inducing kinase (NIK) is required for osteoclastogenesis in response to pathologic stimuli, and its loss leads to functional blockade of both alternative and classical NF-κB caused by cytoplasmic retention by p100. We now show that deletion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01724114674c1d84f57bf82baf5a9e9
https://doi.org/10.1073/pnas.0708576105
https://doi.org/10.1073/pnas.0708576105
Autor:
Deborah V. Novack, Osami Kanagawa, Kunihiko Aya, Muhammad Alhawagri, Hideki Kitaura, Amanda Hagen-Stapleton
Publikováno v:
Journal of Clinical Investigation. 115:1848-1854
NF-(kappa)B is an important component of both autoimmunity and bone destruction in RA. NF-(kappa)B-inducing kinase (NIK) is a key mediator of the alternative arm of the NF-(kappa)B pathway, which is characterized by the nuclear translocation of RelB/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2dfff7ea8a320cd0546a7975c83134
https://doi.org/10.1172/jci23763
https://doi.org/10.1172/jci23763
Publikováno v:
Journal of cellular biochemistry. 108(6)
The transcription factor NF-kappaB is essential for osteoclastogenesis and is considered an immune-modulator of rheumatoid arthritis and inflammatory osteolysis. Activation of NF-kappaB subunits is regulated by the upstream IkappaB kinase (IKK) compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3efbe8f0b3ed458bb4fda8cc0a17ab0d
https://pubmed.ncbi.nlm.nih.gov/19830703
https://pubmed.ncbi.nlm.nih.gov/19830703
Autor:
Muhammad Alhawagri, Domenica Foglia, Simon Dai, Jesse E. Otero, Jean Vacher, Manolis Pasparakis, Yousef Abu-Amer
Publikováno v:
The Journal of biological chemistry. 283(36)
It has been reported previously that inhibitory kappaB kinase (IKK) supports osteoclastogenesis through NF-kappaB-mediated prevention of apoptosis. This finding suggests that the ligand for receptor activator of NF-kappaB (RANKL), the master osteocla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1442486a67562d5f7fa125f774486f
https://pubmed.ncbi.nlm.nih.gov/18567579
https://pubmed.ncbi.nlm.nih.gov/18567579
Autor:
Imani Anwisye, Deborah V. Novack, Muhammad Alhawagri, Hideki Kitaura, Sergio Vaira, Roberta Faccio
Osteoclasts (OCs) function to reabsorb bone and are responsible for the bone loss associated with inflammatory arthritis and osteoporosis. OC numbers are elevated in most disorders of accelerated bone destruction, reflecting altered rates of precurso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebb436083b0bc724b6afb491b00b9af
https://europepmc.org/articles/PMC2373419/
https://europepmc.org/articles/PMC2373419/
