Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Muhammad Al-Hajj"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 403-410 (2023)
The success of chimeric antigen receptor (CAR) T cell therapies in refractory hematologic malignancies has prompted investigation of their efficacy in solid tumors. AUTO6NG is a dual-transduced GD2-targeting CAR that encodes distinct modules designed
Externí odkaz:
https://doaj.org/article/3848e2ddca5b4d85af0e2f6d1eecc480
Autor:
Simon Thomas, Julia Taylor, Manuel Rodriguez-Justo, Kwee Yong, Mathieu Ferrari, Shimobi Onuoha, Sonja Zweegman, Rakesh Popat, Lydia Lee, Wen Chean Lim, Daria Galas-Filipowicz, Kent Fung, Dominic Patel, Zulaikha Akbar, Elena Alvarez Mediavilla, Patrycja Wawrzyniecka, Debarati Shome, Rogier M Reijmers, Trillian Gregg, Leigh Wood, William Day, Virginie Cerec, Shaun Cordoba, Nushmia Khokhar, Vijay Peddareddigari, Muhammad Al-Hajj, Jim Cavet, Martin Pule
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background We used a proliferating ligand (APRIL) to construct a ligand-based third generation chimeric antigen receptor (CAR) able to target two myeloma antigens, B-cell maturation antigen (BCMA) and transmembrane activator and CAML interactor.Metho
Externí odkaz:
https://doaj.org/article/8067650d1c374058a81e8dfb09c80620
Autor:
Christopher Shelton, Muhammad Al-Hajj, Jeremy Griggs, Adam Walker, Trevor Wattam, Michael Steward, James Tunstead, William Fieles, Daniel Rycroft, Sarah Friel, Louisa Anderson, Gavin Jones, David Granger, Heather Jackson
Supplementary Figure 1: Testing GSK3178022 binding to human LRP6, mouse LRP6 and human LRP5 in an ELISA format. Supplmentary Table 1: Mutation data in PDX models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe050ba079d65f1fd57e7881f26b33d
https://doi.org/10.1158/1541-7786.22514236.v1
https://doi.org/10.1158/1541-7786.22514236.v1
Autor:
Christopher Shelton, Muhammad Al-Hajj, Jeremy Griggs, Adam Walker, Trevor Wattam, Michael Steward, James Tunstead, William Fieles, Daniel Rycroft, Sarah Friel, Louisa Anderson, Gavin Jones, David Granger, Heather Jackson
Supplemental Figure Legend 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ad250ba6487c95e23b4b0f4fcf1e55
https://doi.org/10.1158/1541-7786.22514239
https://doi.org/10.1158/1541-7786.22514239
Autor:
Brian Weinert, Tine Hannibal, Preeyam Patel, Evelina Martinenaite, Marion Chapellier, Marco Carretta, Alireza Alavi, Ayako Pedersen, Muhammad Al-Hajj
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Marion Chapellier, Marco Carretta, Ines Lecoq, Evelina Martinenaite, Tine Hannibal, Preeyam Patel, Brian Weinert, Alireza Alavi, Muhammad Al-Hajj, Ayako Pedersen
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Nushmia Z. Khokhar, Denise Bonney, Paul Virgo, Saket Srivastava, Simon Thomas, Ram Jha, Jan Chu, Shaun Cordoba, Robert Chiesa, Persis Amrolia, Yiyun Zhang, Jeremy Hancock, Rachael Hough, Carlotta Peticone, Shimobi Onuoha, Kanchan Rao, Vania Baldan, Kevin Duffy, Paul Veys, Lucy Wheeler, Robert Wynn, William Day, Daniela Soriano Pignataro, Sara Ghorashian, Giovanna Lucchini, Koval Smith, Martin Pule, Liz Clark, Vijay G R Peddareddigari, Mathieu Ferrari, Sabine Domning, Ajay Vora, Frederick Arce Vargas, Muhammad Al-Hajj, Mei Mei Fung, Farzin Farzaneh
Publikováno v:
Nature Medicine
Chimeric antigen receptor (CAR) T cells targeting CD19 or CD22 have shown remarkable activity in B cell acute lymphoblastic leukemia (B-ALL). The major cause of treatment failure is antigen downregulation or loss. Dual antigen targeting could potenti
Publikováno v:
Journal of Tikrit University for Humanities. 28:18-41
لقد بات إصلاح منظومة التربية و التعليم من القضايا الرئيسية التي تؤرق بال المسؤولين الحكوميين في شتى أنحاء العالم إيمانا منهم بأن تكوين ا
Autor:
Lorenzo Biassoni, Julie Silvester, Jack Barton, Claire Barton, Muhammad Al-Hajj, Clare Marriott, Talia Gileadi, Thalia Loka, John Anderson, Simon Thomas, Karin Straathof, Stephanie Traub, Sarah Inglott, Lesley Robson, Evangelia Kokalaki, Giuseppe Barone, Kieran McHugh, Lily Elson, Karen Dyer, Karen Howe, Sarita Depani, Teresa Marafioti, Ami Bedi, Natalie Sizer, Sian Stafford, Nigel Westwood, Olumide Ogunbiyi, Gordon Weng-Kit Cheung, Barry Flutter, Sue Brook, Martin Pule, Dyanne Rampling, Gary Wright, Kimberly Gilmour, Rebecca Wallace, Catriona Duncan, David P. Edwards, Ailish Barry, William Day, Neha Jain, Ilaria Dragoni, Ayse U. Akarca
Publikováno v:
Science Translational Medicine. 12
The reprogramming of a patient’s immune system through genetic modification of the T cell compartment with chimeric antigen receptors (CARs) has led to durable remissions in chemotherapy-refractory B cell cancers. Targeting of solid cancers by CAR-
Autor:
Christopher A. Shelton, Muhammad Al-Hajj, Louisa Anderson, Jeremy Griggs, Sarah Friel, Michael Steward, Gavin Jones, William E. Fieles, Heather Jackson, Adam Walker, David W Granger, Trevor Anthony Kenneth Wattam, Daniel Rycroft, James Tunstead
Publikováno v:
Molecular Cancer Research. 14:859-868
Aberrant WNT signaling is associated with the formation and growth of numerous human cancer types. The low-density lipoprotein receptor-related protein 6 (LRP6) is the least redundant component of the WNT receptor complex with two independent WNT lig