Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Muh-Tsann Lai"'
Autor:
Sheela Bhattacharjee, Allan George, Scott G. Lundeen, Olivia Linton, Pamela Tannenbaum, Xuqing Zhang, Donna Haynes-Johnson, Tifanie Sbriscia, Zhihua Sui, Muh-Tsann Lai
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 134:51-58
Selective androgen receptor modulators (SARMs) are androgens with tissue-selective activity. SARMs that have anabolic activity on muscle while having minimal stimulatory activity on prostate are classified as SARM agonists. They can be used to preven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274894ce92f19f7cce1d2ec5e29622ad
https://doi.org/10.1016/j.jsbmb.2012.10.015
https://doi.org/10.1016/j.jsbmb.2012.10.015
Autor:
Zhihua Sui, Raymond A. Ng, Muh-Tsann Lai, Olivia Linton, Scott G. Lundeen, Sheela Bhattacharjee, George F. Allan, Tifanie Sbriscia, Donna Haynes-Johnson
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 110:207-213
Androgens are required for the maintenance of normal sexual activity in adulthood and for enhancing muscle growth and lean body mass in adolescents and adults. Androgen receptor (AR) ligands with tissue selectivity (selective androgen receptor modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3967956d5c7bb78cbe93df34d78c81
https://doi.org/10.1016/j.jsbmb.2007.10.012
https://doi.org/10.1016/j.jsbmb.2007.10.012
Autor:
Olivia Linton, Tifanie Sbriscia, Xuqing Zhang, George F. Allan, Muh-Tsann Lai, Sheela Bhattacharjee, Zhihua Sui, Donna Haynes-Johnson, Scott G. Lundeen, Pamela Tannenbaum
Publikováno v:
Endocrine. 32:41-51
Androgen receptor (AR) ligands with tissue selectivity (selective androgen receptor modulators, or SARMs) have potential for treating muscle wasting, hypogonadism of aging, osteoporosis, female sexual dysfunction, and other indications. JNJ-28330835
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda1f9701470ab79fa74d84ce290bc93
https://doi.org/10.1007/s12020-007-9005-2
https://doi.org/10.1007/s12020-007-9005-2
Autor:
Muh-Tsann Lai, Weiqin Jiang, Zhihua Sui, James C. Lanter, Do Won Hahn, George F. Allan, Olivia Linton, James J. Fiordeliso, Scott G. Lundeen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:123-126
A series of novel 2-(1H-indol-2-yl)-propan-2-ols have been designed, synthesized, and screened for their ability to inhibit testosterone-induced prostate weight increases in immature rats. Through the use of this paradigm, we were able to identify co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041cce7063cd70cb352a308467308f11
https://doi.org/10.1016/j.bmcl.2006.09.086
https://doi.org/10.1016/j.bmcl.2006.09.086
Publikováno v:
Steroids. 71:578-584
Progesterone receptor modulators have diverse potential therapeutic uses, including the treatment of endometriosis, uterine fibroids and breast cancer. Here we describe the molecular properties and preclinical pharmacology of a new steroidal progesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172851d492a081951efad7cc11eef8ea
https://doi.org/10.1016/j.steroids.2006.02.002
https://doi.org/10.1016/j.steroids.2006.02.002
Autor:
Fuyong Du, George F. Allan, Ramesh M. Kanojia, Nareshkumar F. Jain, Zhihua Sui, Amy Musto, Emmanuel Pacia, Muh-Tsann Lai, Guo Jian-Zhong, Jiayi Xu, DoWon Hahn, and Scott Lundeen
Publikováno v:
Journal of Medicinal Chemistry. 49:3056-3059
A novel SERM (selective estrogen receptor modulators), 1-(R), a chromene-derived bisbenzopyran, was discovered to alleviate hot flushes and effectively increase vaginal fluidity in rats. Moreover, 1-(R) was found to have beneficial effects on plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e23139ff8b9adfb003d6086a95b0ff
https://doi.org/10.1021/jm060353u
https://doi.org/10.1021/jm060353u
Publikováno v:
Biology of Reproduction. 61:147-153
Epidermal growth factor (EGF) has been shown to influence FSH-stimulated estradiol (E2) and progesterone (P4) production from granulosa cells. RG 50810, a tyrosine kinase inhibitor (TKI), has previously been shown to inhibit the EGF-receptor tyrosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba6893029d12bbd46fadbe480598e3b
https://doi.org/10.1095/biolreprod61.1.147
https://doi.org/10.1095/biolreprod61.1.147
Autor:
Kimberly N. Beers, Stephanie C. Hamel, Carolyn Campen, Steven K. Wetter, Stephen S. Palmer, Peter J. Connolly, Pat Kraft, Donna Haynes-Johnson, Audrey Phillips, Margaret Kiddoe, Muh Tsann Lai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2551-2556
Research directed toward the discovery of non-steroidal ligands for steroid receptors led to the preparation of a series of substituted 1-phenyl-7-benzyltetrahydroindazole-3-carboxaldehydes. Appropriately substituted 3-formyl analogs (4) were found t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cef67c03decaa77bf0e3cf0545f206f2
https://doi.org/10.1016/s0960-894x(97)10016-6
https://doi.org/10.1016/s0960-894x(97)10016-6
Autor:
Ronald K. Russell, Martin Cousineau, Scott G. Lundeen, DoWon Hahn, Ramesh M. Kanojia, Nareshkumar F. Jain, David M. Ritchie, Muh-Tsann Lai, Guo Jian-Zhong, Xun Li, George F. Allan, Emmanuel Pacia, Jiayi Xu, Sean Peng, Fuyong Du, Zhihua Sui, Amy Musto, Michael Reuman
Publikováno v:
Journal of medicinal chemistry. 52(23)
As part of a program aimed at the development of selective estrogen receptor modulators (SERMs), novel chromene scaffolds, benzopyranobenzoxapanes, were discovered. Many compounds showed binding affinity as low as 1.6-200 nM, displayed antagonist beh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a373fd7e9d9cd82671bd1a5edd0cc8d
https://pubmed.ncbi.nlm.nih.gov/19366247
https://pubmed.ncbi.nlm.nih.gov/19366247
Autor:
Zhihua Sui, Vernon C. Alford, Olivia Linton, Xuqing Zhang, Ronald K. Russell, George F. Allan, Muh-Tsann Lai, James C. Lanter, Scott G. Lundeen, Kenneth M. Wells, James J. Fiordeliso
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(9)
Through an in vivo screening model, we developed the in vivo SAR of beta-alkylthio indolyl carbinols. Through these efforts we identified a compound with potent oral in vivo efficacy in both immature and mature rat prostate weight reduction models an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b775788f1d9d70864c1209376a8b72
https://pubmed.ncbi.nlm.nih.gov/17337185
https://pubmed.ncbi.nlm.nih.gov/17337185