Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Mugimane G, Manjanatha"'
Autor:
Sharon D. Shelton, Ying Chen, Ji-Eun Seo, Dayton M. Petibone, Nan Mei, Mugimane G. Manjanatha, Xiaoqing Guo, Xilin Li, Stephanie L. Smith-Roe, Volodymyr Tryndyak, Kristine L. Witt
Publikováno v:
Toxicol Sci
Black cohosh extract (BCE) is marketed to women as an alternative to hormone replacement therapy for alleviating menopausal symptoms. Previous studies by the National Toxicology Program revealed that BCE induced micronuclei (MN) and a nonregenerative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74da9d17631bb1cc3a8e0c42999ffa1f
https://doi.org/10.1093/toxsci/kfab044
https://doi.org/10.1093/toxsci/kfab044
Autor:
Timothy W. Robison, Qiang Shi, Nan Mei, Matthew Bryant, Qiangen Wu, Mugimane G. Manjanatha, Lijun Ren, Xiaoqing Guo, Ji-Eun Seo
Publikováno v:
Archives of Toxicology. 94:2207-2224
Primary human hepatocytes (PHHs) are considered the "gold standard" for evaluating hepatic metabolism and toxicity of xenobiotics. In the present study, we evaluated the genotoxic potential of four indirect-acting (requiring metabolic activation) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92239423304478cd1ef219a5dda733d8
https://doi.org/10.1007/s00204-020-02736-z
https://doi.org/10.1007/s00204-020-02736-z
Autor:
Mugimane G Manjanatha
Publikováno v:
Frontiers in Genetics, Vol 6 (2015)
Doxorubicin (DOX) is an antineoplastic drug effective against many human malignancies. DOX’s clinical efficacy is greatly limited because of severe cardiotoxicity. To evaluate if DOX is genotoxic in the heart, approximately 7- week-old, male F344 r
Externí odkaz:
https://doaj.org/article/a9233301f2924503a704c0c50019ee19
Autor:
Mugimane G. Manjanatha, Timothy W. Robison, Wei Ding, Robert H. Heflich, Aisar Atrakchi, Rosalie K. Elespuru, Nan Mei
Publikováno v:
Mutation research. Genetic toxicology and environmental mutagenesis.
Kirkland et al. [Mutation Research/Genetic Toxicology and Environmental Mutagenesis 847 (2019) 403035, https://doi.org/10.1016/j.mrgentox.2019.03.008 ; Mutation Research/Genetic Toxicology and Environmental Mutagenesis 839 (2019): 21–35, https://do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02bad37410959649bdb0081f165c85b
https://pubmed.ncbi.nlm.nih.gov/35483788
https://pubmed.ncbi.nlm.nih.gov/35483788
Autor:
Mugimane G. Manjanatha, Shobhan Gaddameedhi, Hans P. A. Van Dongen, Justin G. Teeguarden, Kenneth I. Porter, Tarana Arman, Osama A. Arshad, Rajendra P. Gajula, Bala S C Koritala, Hugh D. Mitchell, Jason E. McDermott
Publikováno v:
J Pineal Res
Circadian disruption has been identified as a risk factor for health disorders such as obesity, cardiovascular disease, and cancer. Although epidemiological studies suggest an increased risk of various cancers associated with circadian misalignment d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0e3cedd06a72950ee358a6374b9462
https://doi.org/10.1111/jpi.12726
https://doi.org/10.1111/jpi.12726
Autor:
Xiaoqing Guo, Xilin Li, Si Chen, Lei Guo, Nan Mei, Mugimane G. Manjanatha, Tong Zhou, Kristine L. Witt, Qiangen Wu, Ji-Eun Seo
Publikováno v:
Toxicol Sci
Metabolism plays a key role in chemical genotoxicity; however, most mammalian cells used for in vitro genotoxicity testing lack effective metabolizing enzymes. We recently developed a battery of TK6-derived cell lines that individually overexpress 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb053eb9545891f5f1f86f518861a1f1
https://europepmc.org/articles/PMC7334878/
https://europepmc.org/articles/PMC7334878/
Publikováno v:
Environmental and Molecular Mutagenesis. 58:508-521
DNA damage and alterations in global DNA methylation status are associated with multiple human diseases and are frequently correlated with clinically relevant information. Therefore, assessing DNA damage and epigenetic modifications, including DNA me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aed8a6c35550d9dbd85ee9c3c639dd8
https://doi.org/10.1002/em.22101
https://doi.org/10.1002/em.22101
Autor:
Meagan B. Myers, Ying Chen, Sharon D. Shelton, Nigel P. Moore, Karen L. McKim, Bruce C. Allen, Martha M. Moore, Lynne T. Haber, B. Bhaskar Gollapudi, Barbara L. Parsons, Mugimane G. Manjanatha
Publikováno v:
Environmental and Molecular Mutagenesis. 58:122-134
Ethylene oxide (EO) is a direct acting alkylating agent; in vitro and in vivo studies indicate that it is both a mutagen and a carcinogen. However, it remains unclear whether the mode of action (MOA) for cancer for EO is a mutagenic MOA, specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed1fdec9b10490be25ff4bec44c60b26
https://doi.org/10.1002/em.22080
https://doi.org/10.1002/em.22080
Autor:
Shuichi Hamada, David Kirkland, George R. Douglas, Mirjam Luijten, Katsuyoshi Horibata, Andrew Williams, Hans-Joerg Martus, Mugimane G. Manjanatha, Carol Beevers, Jan van Benthem, David P. Lovell, Takeshi Morita, Brian Burlinson, Stephen D. Dertinger, Yoshifumi Uno, Nan Mei, Wakako Ohyama
The working group reached complete or majority agreement on many issues. Results from TGR and in vivo comet assays for 91 chemicals showed they have similar ability to detect in vivo genotoxicity per se with bacterial mutagens and Ames-positive carci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebca260669d6c235c5ecdb2ed57a8860
http://hdl.handle.net/10029/623570
http://hdl.handle.net/10029/623570
Publikováno v:
The Journal of Toxicological Sciences. 41:719-730
Potential health risks for humans from dietary exposure to acrylamide (AA) and its reactive epoxide metabolite, glycidamide (GA), exist because substantial amounts of AA are found in a variety of fried and baked starchy foods. AA is tumorigenic in ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d91b8d81fd9b7d2f116e6ec935a5bbc9
https://doi.org/10.2131/jts.41.719
https://doi.org/10.2131/jts.41.719