Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Mufaddal Mahesri"'
Publikováno v:
BMC Geriatrics, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Medications with potent anticholinergic properties have well-documented adverse effects. A high cumulative anticholinergic burden may arise from the concurrent use of multiple medications with weaker anticholinergic effects. We so
Externí odkaz:
https://doaj.org/article/a7fd462dde154a329956c81d11378634
Autor:
John Laurentiev, Dae Hyun Kim, Mufaddal Mahesri, Kuan-Yuan Wang, Lily G Bessette, Cassandra York, Heidi Zakoul, Su Been Lee, Li Zhou, Kueiyu Joshua Lin
Publikováno v:
Journal of Medical Internet Research, Vol 26, p e47739 (2024)
BackgroundAssessment of activities of daily living (ADLs) and instrumental ADLs (iADLs) is key to determining the severity of dementia and care needs among older adults. However, such information is often only documented in free-text clinical notes w
Externí odkaz:
https://doaj.org/article/a7c8a75e95424d5d92665408fb74ba6c
Autor:
Julie C. Lauffenburger, Thomas Isaac, Lorenzo Trippa, Punam Keller, Ted Robertson, Robert J. Glynn, Thomas D. Sequist, Dae H. Kim, Constance P. Fontanet, Edward W. B. Castonguay, Nancy Haff, Renee A. Barlev, Mufaddal Mahesri, Chandrashekar Gopalakrishnan, Niteesh K. Choudhry
Publikováno v:
Implementation Science, Vol 16, Iss 1, Pp 1-11 (2021)
Abstract Background The prescribing of high-risk medications to older adults remains extremely common and results in potentially avoidable health consequences. Efforts to reduce prescribing have had limited success, in part because they have been sub
Externí odkaz:
https://doaj.org/article/7b128188241647069341e3d6259f1acf
Publikováno v:
BMC Endocrine Disorders, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Diabetes is a leading cause of Medicare spending; predicting which individuals are likely to be costly is essential for targeting interventions. Current approaches generally focus on composite measures, short time-horizons, or pat
Externí odkaz:
https://doaj.org/article/3697d3be3def40e1a6ee38052d27206b
Autor:
Mufaddal Mahesri, Kristyn Chin, Abheenava Kumar, Aditya Barve, Rachel Studer, Raquel Lahoz, Rishi J Desai
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252903 (2021)
BackgroundEjection fraction (EF) is an important prognostic factor in heart failure (HF), but administrative claims databases lack information on EF. We previously developed a model to predict EF class from Medicare claims. Here, we evaluated the per
Externí odkaz:
https://doaj.org/article/937e1ffa85004b9e9322b447c29ed62d
Autor:
Rishi J. Desai, Vijay R. Varma, Tobias Gerhard, Jodi Segal, Mufaddal Mahesri, Kristyn Chin, Edward Nonnenmacher, Avinash Gabbeta, Anup M. Mammen, Sudhir Varma, Daniel B. Horton, Seoyoung C. Kim, Sebastian Schneeweiss, Madhav Thambisetty
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Abstract Drug discovery for disease‐modifying therapies for Alzheimer's disease and related dementias (ADRD) based on the traditional paradigm of experimental animal models has been disappointing. We describe the rationale and design of the Drug Re
Externí odkaz:
https://doaj.org/article/06dc1bcc61244f1981ac98d3c64492b5
Autor:
Vijay R. Varma, Rishi J. Desai, Sheeja Navakkode, Lik-Wei Wong, Carlos Anerillas, Tina Loeffler, Irene Schilcher, Mufaddal Mahesri, Kristyn Chin, Daniel B. Horton, Seoyoung C. Kim, Tobias Gerhard, Jodi B. Segal, Sebastian Schneeweiss, Myriam Gorospe, Sreedharan Sajikumar, Madhav Thambisetty
Publikováno v:
Molecular Psychiatry. 28:1312-1326
We recently nominated cytokine signaling through the Janus-kinase–signal transducer and activator of transcription (JAK/STAT) pathway as a potential AD drug target. As hydroxychloroquine (HCQ) has recently been shown to inactivate STAT3, we hypothe
Autor:
John Laurentiev, Dae Hyun Kim, Mufaddal Mahesri, Kuan-Yuan Wang, Lily G. Bessette, Cassandra York, Heidi Zakoul, Su Been Lee, Li Zhou, Joshua Lin
BACKGROUND Assessment of activities of daily living (ADLs) and instrumental activities of daily living (iADLs) is key to determining severity of dementia and care needs among older adults. However, such information is often only documented in free-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dff1c9ef8885c0fce25418f6145be2d8
https://doi.org/10.2196/preprints.47739
https://doi.org/10.2196/preprints.47739
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the same indication. This i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29b0478020bbdf5e7ef365e5c9256ba4
Publikováno v:
Arthritis careresearch.
Despite increasing overall healthcare spending over the past several decades, little is known about long-term patterns of spending among US patients with gout. Current approaches to assessing spending typically focus on composite measures or patients