Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Muench, SP"'
The P2X7 receptor (P2X7R) is a calcium-permeable cation channel activated by high concentrations of extracellular ATP. It plays a role in vital physiological processes, particularly in innate immunity, and is dysregulated in pathological conditions s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ea6f12878f679cf5ad472da9f1b3886d
The P2X7 receptor, originally known as the P2Z receptor due to its distinctive functional properties, has a structure characteristic of the ATP-gated ion channel P2X receptor family. The P2X7 receptor is an important mediator of ATP-induced purinergi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::280817b891ec30c6bbcd0f26efdb51a9
https://eprints.whiterose.ac.uk/173622/6/Jiang2021_Article_StructuralBasisForTheFunctiona.pdf
https://eprints.whiterose.ac.uk/173622/6/Jiang2021_Article_StructuralBasisForTheFunctiona.pdf
Autor:
Vasilca, V, Sadeghpour, A, Rawson, S, Hawke, LE, Baldwin, SA, Wilkinson, T, Bannister, D, Postis, VLG, Rappolt, M, Muench, SP, Jeuken, LJC
Publikováno v:
Analytical Biochemistry
Screening assays performed against membrane protein targets (e.g. phage display) are hampered by issues arising from protein expression and purification, protein stability in detergent solutions and epitope concealment by detergent micelles. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ba3c5975a92bf23db2996fa230e44043
http://europepmc.org/articles/PMC5948183
http://europepmc.org/articles/PMC5948183
Autor:
Jamali, MAM, Gopalasingam, CC, Johnson, RM, Tosha, T, Muramoto, K, Muench, SP, Antonyuk, SV, Shiro, Y, Hasnain, SS
Neisseria meningitidis is carried by nearly a billion humans, causing developmental impairment and over 100 000 deaths a year. A quinol-dependent nitric oxide reductase (qNOR) plays a critical role in the survival of the bacterium in the human host.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f70e4536472b26238c413b2ba78b1ddd
https://eprints.whiterose.ac.uk/158353/8/pw5011.pdf
https://eprints.whiterose.ac.uk/158353/8/pw5011.pdf
Type II NADH:quinone oxidoreductase (NDH-2) plays a crucial role in the respiratory chains of many organisms. Its absence in mammalian cells makes NDH-2 an attractive new target for developing antimicrobials and anti-protozoal agents. We established
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e20c3e8fee65bc8159a5aa0b076514d6
https://eprints.whiterose.ac.uk/155016/1/ja-2019-10254c.R2_Proof_hi.pdf
https://eprints.whiterose.ac.uk/155016/1/ja-2019-10254c.R2_Proof_hi.pdf
Publikováno v:
Biochimica et Biophysica Acta
The field of membrane protein structural biology has been revolutionized over the last few years with a number of high profile structures being solved using cryo-EM including Piezo, Ryanodine receptor, TRPV1 and the Glutamate receptor. Further develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ec658400421b206f4448305ad7502667
http://europepmc.org/articles/PMC5780298
http://europepmc.org/articles/PMC5780298
Transport of molecules and ions across biological membranes is an essential process in all organisms. It is carried out by a range of evolutionarily conserved primary and secondary transporters. A significant portion of the primary transporters belon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::a83b05034a3a2647da46ac39048786a0
Publikováno v:
Molecular Membrane Biology
Membrane proteins are ubiquitous in biology and are key targets for therapeutic development. Despite this, our structural understanding has lagged behind that of their soluble counterparts. This review provides an overview of this important field, fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3e568b4cfe25937b92843ca0b6d8c4f1
http://europepmc.org/articles/PMC5206964
http://europepmc.org/articles/PMC5206964
Autor:
lykins, JD, Filippova, E, Halavaty, AS, Minasov, G, Zhou, Y, Dubrovska, I, Flores, KJ, Shuvalova, LA, Ruan, J, El Bissati, K, Dovgin, S, Roberts, CW, Woods, S, Moulton, JD, Moulton, H, McPhillie, MJ, Muench, SP, Fishwick, CWG, Sabini, E, Shanmugam, D, Roos, DS, McLeod, R, Anderson, WF, Ngô, HM
Toxoplasma gondii, an Apicomplexan parasite, causes significant morbidity and mortality, including severe disease in immunocompromised hosts and devastating congenital disease, with no effective treatment for the bradyzoite stage. To address this, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e1bde764546127fee236bd5bea05787e
https://eprints.whiterose.ac.uk/136789/6/fcimb-08-00352.pdf
https://eprints.whiterose.ac.uk/136789/6/fcimb-08-00352.pdf
Autor:
Drulyte, I, Johnson, RM, Hesketh, EL, Hurdiss, DL, Scarff, CA, Porav, SA, Ranson, NA, Muench, SP, Thompson, RF
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
This paper describes different approaches that cryo-EM users can take to improve the quality of their sample distribution and ice for high-resolution single-particle cryo-EM.
Cryo-electron microscopy (cryo-EM) can now be used to determine high-r
Cryo-electron microscopy (cryo-EM) can now be used to determine high-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2322095dcb307789d4c29cf8d2af3002
https://eprints.whiterose.ac.uk/130715/15/ic5104.pdf
https://eprints.whiterose.ac.uk/130715/15/ic5104.pdf