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Effect of sacubitril/valsartan on recurrent events in the prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF)

Autor: Mogensen, Ulrik M., Gong, Jianjian, Jhund, Pardeep S., Shen, Li, Køber, Lars, Desai, Akshay S., Lefkowitz, Martin P., Packer, Milton, Rouleau, Jean L., Solomon, Scott D., Claggett, Brian L., Swedberg, Karl, Zile, Michael R., Mueller-Velten, Guenther, McMurray, John J.V.

Publikováno v: Mogensen, U M, Gong, J, Jhund, P S, Shen, L, Køber, L, Desai, A S, Lefkowitz, M P, Packer, M, Rouleau, J L, Solomon, S D, Claggett, B L, Swedberg, K, Zile, M R, Mueller-Velten, G & McMurray, J J V 2018, ' Effect of sacubitril/valsartan on recurrent events in the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF) ', European Journal of Heart Failure, vol. 20, no. 4, pp. 760-768 . https://doi.org/10.1002/ejhf.1139

Aims:\ud Recurrent hospitalizations are a major part of the disease burden in heart failure (HF), but conventional analyses consider only the first event. We compared the effect of sacubitril/valsartan vs. enalapril on recurrent events, incorporating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9ef5e66e972762ba4f95a62c093f53dc
https://acuresearchbank.acu.edu.au/item/8877w/effect-of-sacubitril-valsartan-on-recurrent-events-in-the-prospective-comparison-of-arni-with-acei-to-determine-impact-on-global-mortality-and-morbidity-in-heart-failure-trial-paradigm-hf

Independent academic Data Monitoring Committees for clinical trials in cardiovascular and cardiometabolic diseases

Autor: Filippatos, Gerasimos S., de Graeff, Pieter, Bax, Jeroen J., Borg, John-Joseph, Cleland, John G.F., Dargie, Henry J., Flather, Marcus, Ford, Ian, Friede, Tim, Greenberg, Barry, Henon-Goburdhun, Cécile, Holcomb, Richard, Horst, Bradley, Lekakis, John, Mueller-Velten, Guenther, Papavassiliou, Athanasios G., Prasad, Krishna, Rosano, Giuseppe M.C., Severin, Thomas, Sherman, Warren, Stough, Wendy Gattis, Swedberg, Karl, Tavazzi, Luigi, Tousoulis, Dimitris, Vardas, Panagiotis, Ruschitzka, Frank, Anker, Stefan D.

Publikováno v: European Journal of Heart Failure, 19(4), 449-456

Data Monitoring Committees (DMCs) play a crucial role in the conducting of clinical trials to ensure the safety of study participants and to maintain a trial's scientific integrity. Generally accepted standards exist for DMC composition and operation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3fba93bc09c40fd7ff0a42badd687f88
https://pubmed.ncbi.nlm.nih.gov/28271595