Interference with the urokinase plasminogen activator system: a promising therapy concept for solid tumours

Autor: Magdolen, Nadia Harbeck, Michael Schmitt, Muehlenweg B, Sperl S

Publikováno v: Expert Opinion on Biological Therapy. 1:683-691

There is abundant evidence that the plasminogen activator (PA) system with its key components uPA (urokinase-type plasminogen activator), its cell surface receptor uPA-R (CD87) and its inhibitor PAI-1 plays a key role in tumour invasion and metastasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318ef1d4c96040b9fec365d2422873fc
https://doi.org/10.1517/14712598.1.4.683

The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin

Autor: Coles, M, Diercks, T, Muehlenweg, B, Bartsch, S, Zolzer, V, Tschesche, Harald, Kessler, H

Publikováno v: Journal of molecular biology. 289(1)

Human neutrophil gelatinase-associated lipocalin (HNGAL) is a member of the lipocalin family of extracellular proteins that function as transporters of small, hydrophobic molecules. HNGAL, a component of human blood granulocytes, binds bacterially de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::36759b21d4e6befdf76a9883cf83160a
https://pubmed.ncbi.nlm.nih.gov/10339412

Combined Antitumor Effect of the Serine Protease Urokinase Inhibitor Upamostat and the Sphingosine Kinase 2 Inhibitor Opaganib on Cholangiocarcinoma Patient-Derived Xenografts.

Autor: Asumda, Faizal Z.¹ (AUTHOR) fasumda@augusta.edu, Campbell, Nellie A.² (AUTHOR) campbell.nellie@mayo.edu, Hassan, Mohamed A.³ (AUTHOR), Fathi, Reza⁴ (AUTHOR) reza@redhillbio.com, Vasquez Rico, Daniella F.⁵ (AUTHOR) vasqu170@umn.edu, Kiem, Melanie^2,6 (AUTHOR) moore.michael.j@wustl.edu, Vang, Ethan V.² (AUTHOR) zhu.xinli@mayo.edu, Kim, Yo Han⁷ (AUTHOR) kim.yohan@mayo.edu, Luo, Xin⁸ (AUTHOR), O'Brien, Daniel R.⁹ (AUTHOR) obrien.daniel@mayo.edu, Buhrow, Sarah A.¹⁰ (AUTHOR) buhrow.sarah@mayo.edu, Reid, Joel M.¹⁰ (AUTHOR) reid@mayo.edu, Moore, Michael J.² (AUTHOR), Ben-Yair, Vered Katz⁴ (AUTHOR) mark@redhillbio.com, Levitt, Mark L.⁴ (AUTHOR), Leiting, Jennifer L.¹¹ (AUTHOR) leiting.jennifer@mayo.edu, Abdelrahman, Amro M.¹² (AUTHOR) abdelrahman.amro@mayo.edu, Zhu, Xinli^2,13 (AUTHOR), Lucien, Fabrice⁷ (AUTHOR) lucien-matteoni.fabrice@mayo.edu, Truty, Mark J.¹² (AUTHOR) truty.mark@mayo.edu

Publikováno v: Cancers. Mar2024, Vol. 16 Issue 5, p1050. 15p.

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