Zobrazeno 1 - 10 of 232 pro vyhledávání: '"Muehlan C"'
1
Akademický článek
Transfer of the Dual Orexin Receptor Antagonist Daridorexant into Breast Milk of Healthy Lactating Women.
Autor: Kaufmann P; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Muehlan C; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Anliker-Ort M; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Sabattini G; Preclinical Pharmacokinetics and Metabolism, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Siebers N; Labcorp, Madison, WI, USA., Dingemanse J; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Publikováno v: Journal of clinical pharmacology [J Clin Pharmacol] 2024 Oct; Vol. 64 (10), pp. 1278-1287. Date of Electronic Publication: 2024 May 12.
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2
Akademický článek
Pharmacokinetics, safety, and efficacy of daridorexant in Japanese subjects: Results from phase 1 and 2 studies.
Autor: Uchiyama M; Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.; Tokyo Adachi Hospital, Tokyo, Japan., Mishima K; Department of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, Japan., Yagi T; Kurume University School of Medicine, Fukuoka, Japan., Yoshihara T; SOUSEIKAI Fukuoka Mirai Hospital Clinical Research Center, Fukuoka, Japan., Eto T; SOUSEIKAI Hakata Clinic, Fukuoka, Japan., Muehlan C; Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Togo O; Data Management & Biometry, Nxera Pharma Japan Co., Ltd, Tokyo, Japan., Inoue Y; Yoyogi Sleep Disorder Center, Tokyo, Japan.
Publikováno v: Journal of sleep research [J Sleep Res] 2024 Aug 08, pp. e14302. Date of Electronic Publication: 2024 Aug 08.
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3
Akademický článek
Nighttime safety of daridorexant: Evaluation of responsiveness to an external noise stimulus, postural stability, walking, and cognitive function.
Autor: Magliocca M; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Koopmans I; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands., Vaillant C; Global Life Cycle Management, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Lemoine V; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Zuiker R; Centre for Human Drug Research, Leiden, The Netherlands., Dingemanse J; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Muehlan C; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Publikováno v: Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2024 Dec 06, pp. 2698811241293997. Date of Electronic Publication: 2024 Dec 06.
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4
Akademický článek
The orexin story and orexin receptor antagonists for the treatment of insomnia.
Autor: Muehlan C; Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Roch C; Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Vaillant C; Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Dingemanse J; Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Publikováno v: Journal of sleep research [J Sleep Res] 2023 Dec; Vol. 32 (6), pp. e13902. Date of Electronic Publication: 2023 Apr 22.
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5
Akademický článek
The interactive walkway provides fit-for-purpose fall-risk biomarkers in the elderly: Comparison of zolpidem and suvorexant.
Autor: Koopmans I; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands., Geerse D; Leiden University Medical Center, Leiden, The Netherlands.; Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands., de Ridder L; Centre for Human Drug Research, Leiden, The Netherlands., Roerdink M; Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands., Juachon MJ; Centre for Human Drug Research, Leiden, The Netherlands., Muehlan C; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland., Dingemanse J; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland., van Gerven J; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands., Groeneveld GJ; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands., Zuiker R; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands.
Publikováno v: Clinical and translational science [Clin Transl Sci] 2024 Jul; Vol. 17 (7), pp. e13875.
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6
Akademický článek
Effect of Liver Cirrhosis on the Pharmacokinetics, Metabolism, and Tolerability of Daridorexant, A Novel Dual Orexin Receptor Antagonist.
Autor: Berger B; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, Allschwil, 4123, Switzerland. benjamin.berger@idorsia.com., Dingemanse J; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, Allschwil, 4123, Switzerland., Sabattini G; Department of Preclinical Drug Metabolism and Pharmacokinetics, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, Allschwil, 4123, Switzerland., Delahaye S; Department of Preclinical Drug Metabolism and Pharmacokinetics, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, Allschwil, 4123, Switzerland., Duthaler U; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, 4031, Switzerland.; Department of Biomedicine, University of Basel, Basel, 4031, Switzerland., Muehlan C; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, Allschwil, 4123, Switzerland., Krähenbühl S; Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, 4031, Switzerland.
Publikováno v: Clinical pharmacokinetics [Clin Pharmacokinet] 2021 Oct; Vol. 60 (10), pp. 1349-1360. Date of Electronic Publication: 2021 May 18.
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7
Akademický článek
Impact of Daridorexant, a Dual Orexin Receptor Antagonist, on Cardiac Repolarization Following Bedtime Dosing: Results from a Thorough QT Study Using Concentration-QT Analysis.
Autor: Schilling U; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland., Henrich A; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland., Muehlan C; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland., Krause A; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland., Dingemanse J; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland. jasper.dingemanse@idorsia.com., Ufer M; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
Publikováno v: Clinical drug investigation [Clin Drug Investig] 2021 Aug; Vol. 41 (8), pp. 711-721. Date of Electronic Publication: 2021 Jul 31.
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8
Akademický článek
Pharmacological Interactions between the Dual Orexin Receptor Antagonist Daridorexant and Ethanol in a Double-Blind, Randomized, Placebo-Controlled, Double-Dummy, Four-Way Crossover Phase I Study in Healthy Subjects.
Autor: Berger B; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland. benjamin.berger@idorsia.com., Brooks S; Centre for Human Drug Research (CHDR), Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands., Zuiker R; Centre for Human Drug Research (CHDR), Leiden, The Netherlands., Richard M; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland., Muehlan C; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland., Dingemanse J; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
Publikováno v: CNS drugs [CNS Drugs] 2020 Dec; Vol. 34 (12), pp. 1253-1266. Date of Electronic Publication: 2020 Nov 18.
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9
Akademický článek
The dual orexin receptor antagonist daridorexant does not affect the pharmacokinetics of the BCRP substrate rosuvastatin.
Autor: Zenklusen I; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Muehlan C; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Ulc I; CEPHA s.r.o. Komenskeho 19, Pilsen, Czech Republic., Liška J; CEPHA s.r.o. Komenskeho 19, Pilsen, Czech Republic., Dingemanse J; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Publikováno v: Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2020 Nov; Vol. 47 (11), pp. 1843-1849. Date of Electronic Publication: 2020 Jul 21.
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10
Akademický článek
Pharmacokinetics and Pharmacodynamics of the Dual Orexin Receptor Antagonist Daridorexant in Japanese and Caucasian Subjects.
Autor: Muehlan C; From the Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Zuiker R; Centre for Human Drug Research, Leiden, The Netherlands., Peeters P; Centre for Human Drug Research, Leiden, The Netherlands., Rowles R; From the Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland., Dingemanse J; From the Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Publikováno v: Journal of clinical psychopharmacology [J Clin Psychopharmacol] 2020 Mar/Apr; Vol. 40 (2), pp. 157-166.
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